Effect of perioperative autologous versus allogeneic blood transfusion on the immune system in gastric cancer patients

Chen, Gang; Zhang, Fengjiang; Gong, Ming; Yan, Min

doi:10.1631/jzus.2007.b0560

Cited by 55 publications

(37 citation statements)

References 27 publications

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“…27,28 Interestingly, autologous transfusions have induced lesser degrees of immunosuppression than allogeneic transfusions in patients with gastric cancer. 29 However, several studies have theorized that there may be an undiscovered viral or molecular vector that can potentially transmit through a blood transfusion. 7,9,15,18 Data from the Surveillance, Epidemiology, and End Results program showed that in the 1970s and 1980s the overall ageadjusted incidence of NHL had increased by 3% to 4% yearly.…”

Section: Discussionmentioning

confidence: 99%

Association between red blood cell transfusions and development of non-Hodgkin lymphoma: a meta-analysis of observational studies

Castillo

Dalia

Pascual

2010

Blood

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Section: Discussionmentioning

confidence: 99%

Association between red blood cell transfusions and development of non-Hodgkin lymphoma: a meta-analysis of observational studies

Castillo

Dalia

Pascual

2010

Blood

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“…However, reinfusion of unwashed anticoagulated salvaged blood caused NKp cells to rise above preoperative levels, accompanied by enhanced interferon (IFN)-γ synthesis and macrophage activation, suggesting that PTI had been reversed [20,23]. This was supported by studies from others showing enhanced post-operative immunity following reinfusion of fresh anti-coagulated autologous blood [24,25].…”

Section: Introductionmentioning

confidence: 98%

Post-traumatic immunosuppression is reversed by anti-coagulated salvaged blood transfusion: deductions from studying immune status after knee arthroplasty

Islam

Whitehouse

Mehendale

et al. 2014

Clinical and Experimental Immunology

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SummaryMajor trauma increases vulnerability to systemic infections due to poorly defined immunosuppressive mechanisms. It confers no evolutionary advantage. Our objective was to develop better biomarkers of post-traumatic immunosuppression (PTI) and to extend our observation that PTI was reversed by anti-coagulated salvaged blood transfusion, in the knowledge that others have shown that non-anti-coagulated (fibrinolysed) salvaged blood was immunosuppressive. A prospective non-randomized cohort study of patients undergoing primary total knee arthroplasty included 25 who received salvaged blood transfusions collected post-operatively into acid-citrate-dextrose anti-coagulant (ASBT cohort), and 18 non-transfused patients (NSBT cohort). Biomarkers of sterile trauma included haematological values, damage-associated molecular patterns (DAMPs), cytokines and chemokines. Salvaged blood was analysed within 1 and 6 h after commencing collection. Biomarkers were expressed as fold-changes over preoperative values. Certain biomarkers of sterile trauma were common to all 43 patients, including supranormal levels of: interleukin (IL)-6, IL-1-receptor-antagonist, IL-8, heat shock protein-70 and calgranulin-S100-A8/9. Other proinflammatory biomarkers which were subnormal in NSBT became supranormal in ASBT patients, including IL-1β, IL-2, IL-17A, interferon (IFN)-γ, tumour necrosis factor (TNF)-α and annexin-A2. Furthermore, ASBT exhibited subnormal levels of anti-inflammatory biomarkers: IL-4, IL-5, IL-10 and IL-13. Salvaged blood analyses revealed sustained high levels of IL-9, IL-10 and certain DAMPs, including calgranulin-S100-A8/9, alpha-defensin and heat shock proteins 27, 60 and 70. Active synthesis during salvaged blood collection yielded increasingly elevated levels of annexin-A2, IL-1β, Il-1-receptor-antagonist, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IFN-γ, TNF-α, transforming growth factor (TGF)-β1, monocyte chemotactic protein-1 and macrophage inflammatory protein-1α. Elevated levels of high-mobility group-box protein-1 decreased. In conclusion, we demonstrated that anti-coagulated salvaged blood reversed PTI, and was attributed to immune stimulants generated during salvaged blood collection.

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“…In the tumor microenvironment, there is a delicate balance between antitumor immunity and tumor-originated proinfl ammatory activity, which weakens antitumor immunity [12][13][14]. Many researchers have reported that perioperative blood transfusion [15,16], postoperative Abstract Increasing evidence is being reported regarding the hypothesis that several proinfl ammatory and anti-infl ammatory cytokines may promote tumor progression and affect the host antitumor response. However, the manner in which a local cytokine network operates in tumor development remains unclear.…”

mentioning

confidence: 99%

Roles of inflammatory cytokines in the progression of gastric cancer: friends or foes?

et al. 2010

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Although the etiology of gastric cancer has been completely obscure for many decades, several considerable advances in the knowledge of the carcinogenesis and development of gastric cancer have been made in the present era. First, it is well known that Helicobacter pylori infection is associated with the carcinogenesis and development of gastric cancer, suggesting that chronic infl ammation may be implicated in the development of intestinal metaplasia and mutations in oncogenes that precede the development of gastric cancer; indeed, the International Agency for Research on Cancer classifi ed H. pylori as a class I human carcinogen in 1994 [2]. Second, the long-suspected infl uence of genetic susceptibility has been elucidated and several polymorphisms of infl ammatory cytokine genes have been implicated as risk factors for gastric cancer [3][4][5][6][7].Although immune cells constitute an additional and prominent component of the host response to cancer, their participation in tumor pathogenesis remains unclear. Increasing evidence is being reported regarding the hypothesis that several proinfl ammatory and antiinfl ammatory cytokines may promote tumor progression and affect the host antitumor response. Efforts to understand cytokine function during tumor development are complicated by the pleiotropy and redundancy of cytokine action and the manner in which the overall cytokine environment shapes the effects of individual cytokines [8]. At present, most current data support the notion that acute infl ammation triggered by tumorinfi ltrating lymphocytes (TILs) does not induce the normal immunoprotective mechanisms that lead to the eradication of an evolving cancer. Instead, excessively and chronically produced proinfl ammatory mediators are thought to promote tumor progression [9][10][11][12]. In the tumor microenvironment, there is a delicate balance between antitumor immunity and tumor-originated proinfl ammatory activity, which weakens antitumor immunity [12][13][14]. Many researchers have reported that perioperative blood transfusion [15,16], postoperative Abstract Increasing evidence is being reported regarding the hypothesis that several proinfl ammatory and anti-infl ammatory cytokines may promote tumor progression and affect the host antitumor response. However, the manner in which a local cytokine network operates in tumor development remains unclear. We reviewed the literature to examine the consequences of novel insights into infl ammatory cytokines associated with gastric cancer progression. The Medline and EMBASE databases were searched for publications regarding the role of infl ammatory cytokines in the development of gastric cancer. A number of studies have suggested that several proinfl ammatory and anti-infl ammatory cytokines promote tumor progression through the direct activation of nuclear factor-κB (NF-κB) and the upregulation of angiogenesis and adhesion molecules. Furthermore, these processes suppress host antitumor immunity, leading to tumor progression and metastasis. In patients with ad...

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Effect of perioperative autologous versus allogeneic blood transfusion on the immune system in gastric cancer patients

Cited by 55 publications

References 27 publications

Association between red blood cell transfusions and development of non-Hodgkin lymphoma: a meta-analysis of observational studies

Association between red blood cell transfusions and development of non-Hodgkin lymphoma: a meta-analysis of observational studies

Post-traumatic immunosuppression is reversed by anti-coagulated salvaged blood transfusion: deductions from studying immune status after knee arthroplasty

Roles of inflammatory cytokines in the progression of gastric cancer: friends or foes?

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