Effect of Blood Transfusion on the Immune Response of Children with Thalassaemia

Kanakoudi-Tsakalidis, F; Spyroglou, K; Tzafi, R.; Cassimos, C

doi:10.1159/000207861

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…The selective depletion of T-lymphocytes in P-thalassaemia seems to be unassociated with impairment of cell-mediated immunity (Kanakoudi-Tsakalidis et al, 1977). It could be due to a depletion of particular T-cells, perhaps suppressor T-cells.…”

Section: Discussionmentioning

confidence: 94%

Lymphocyte changes in beta-thalassaemia major.

Musumeci¹,

Schilirò²,

Romeo³

et al. 1979

Archives of Disease in Childhood

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SUMMARY Lymphocyte subpopulations were studied in 20 hypertransfused patients with ,B-thalassaemia major, some of whom had been splenectomised. B-lymphocytes were normal but T-lymphocytes were decreased in all patients. The T-cell count was lower in the splenectomised patients than in the nonsplenectomised ones. In the former, the active rosette-forming lymphocytes were also diminished, but the difference was not significant. In all patients the percentage of null cells was greater and the activity of K-cells increased compared with controls.

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Section: Discussionmentioning

confidence: 94%

Lymphocyte changes in beta-thalassaemia major.

Musumeci¹,

Schilirò²,

Romeo³

et al. 1979

Archives of Disease in Childhood

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“…On the basis of these re ports we studied, in correlation to serum iron and ferritin levels, the quantitative peripheral T-subset distribution, as as sessed by means of a series of OKT mon oclonal antibodies (T3, T4, T6, Ts), in 14 patients with TI, 7 of them previously splenectomized. Intermediate thalassaemics were chosen for this investigation be cause they, unlike major thalassaemics, do not require blood transfusion, which could induce per se lymphocyte subset changes by an aspecific immunological stimulation [10,11].…”

Section: Introductionmentioning

confidence: 99%

T-Subset Abnormalities in Thalassaemia intermedia: Possible Evidence for a Thymus Functional Deficiency

et al. 1984

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Peripheral blood T-lymphocyte subsets, evaluated by means of a series of monoclonal antibodies, were assessed in 14 patients affected by thalassaemia intermedia, 7 of them previously splenectomized. A significant reduction of T⁺₄ cells (‘helper’ T cells) was found in almost all patients, whereas T⁺₈ cells (‘suppressor/cytotoxic’) showed a marked increase only in splenectomized subjects. Together with these quantitative T-subset abnormalities, which seemed to be partly affected by either splenectomy or high serum iron levels, an unusual circulating T-cell subpopulation labelled by T₆ monoclonal antibody was detected in all patients. Complete disappearance of T- cells (‘thymo-cyte-like’ T lymphocytes) and normalization of the T₄/T₈ ratio was observed after ‘in vitro’ incubation of patient’s lymphocytes with a crude thymus extract (Thymostimulin). This would suggest the presence of a so far unreported thymus-dependent defect of T-lymphocyte phenotypic maturation occurring in thalassaemia intermedia.

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“…In the present study we assessed NK ac tivity and T lymphocyte subpopulations in homozygous beta thalassemia, a severe transfusion-dependent anemia, in which some studies of cell-mediated immunity have been so far reported [4,13,19,21]. Patients with hemoglobinopathies suffer rather frequently from bacterial and viral infections; furthermore, the incidence of malignancies in thalassemia major (TM) may be an issue of interest, since hyper transfusion regimens together with inten sive removal of iron excess have signifi cantly improved the outcome of the dis ease, and at present the life expectancy of these subjects is lengthened [ 16],…”

Section: Introductionmentioning

confidence: 99%

Natural Killer Cell Activity and T Subpopulations in Thalassemia major

Neri¹,

Brugiatelli²,

Iacopino³

et al. 1984

Acta Haematol

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Natural killer (NK) cell activity against K562 cell targets and the distribution of T cell subpopulations were investigated in the peripheral blood of 25 patients affected by beta thalassemia major, 18 clinically healthy heterozygotes, and 25 age-matched normal subjects. It was found that thalassemia major patients display augmented levels of NK activity [specific lysis 41.9+ (se) 4.5%], while thalassemic carriers behave as normal controls [specific lysis 34.6+ (se) 3.5%]. The increase of NK function was neither related to the splenectomy nor to the siderosis, but rather to the age and the amount of blood units that the patients had received. An imbalance of circulating T subsets with the helper/suppressor cell ratio significantly diminished (p < 0.001) was also detected in homozygotes but not in carriers. The finding that NK function is enhanced in homozygous beta thalassemia might be of clinical interest in assessing the risk of development of malignancies in these patients.

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Effect of Blood Transfusion on the Immune Response of Children with Thalassaemia

Cited by 6 publications

References 9 publications

Lymphocyte changes in beta-thalassaemia major.

Lymphocyte changes in beta-thalassaemia major.

T-Subset Abnormalities in Thalassaemia intermedia: Possible Evidence for a Thymus Functional Deficiency

Natural Killer Cell Activity and T Subpopulations in Thalassemia major

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