Effect of Blueberry Feeding on Lipids and Oxidative Stress in the Serum, Liver and Aorta of Guinea Pigs Fed on a High-Cholesterol Diet

Çoban, Jale; Evran, Betül; Özkan, Ferda; Çevik, Aydın; Doğru‐Abbasoğlu, Semra; Uysal, Müjdat

doi:10.1271/bbb.120722

Cited by 30 publications

(41 citation statements)

References 23 publications

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“…Therefore, in the current study, whole fresh BB supplemented diets were used and their concentrations were chosen according to previous studies. 40,41,44,45 According to our results, BB treatment decreased high activities of serum ALT, AST, and LDH activities and hepatic MDA, DC, and PC levels, but GSH levels together with SOD, CAT, and GSH-Px activities and their mRNA expressions did not change. The incomplete cirrhosis which was seen in the DEN group was not observed in the DEN + BB group.…”

Section: Ishak Stage Gst-pimentioning

confidence: 61%

Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats

Bingül

Başaran-Küçükgergin

Aydın

et al. 2016

Int J Immunopathol Pharmacol

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Diethylnitrosamine (DEN)-induced liver cancer normally develops in stages that progress from cirrhosis and carcinoma. Increased oxidative stress is suggested to play a role in DEN-induced carcinogenicity. Blueberries (BB) contain high antioxidant capacity. We investigated the effect of BB supplementation on development of DEN-induced cirrhosis and neoplastic lesions in the liver. Rats were injected with DEN (200 mg/kg; i.p.) three times with an interval of 15 days at 4, 6, and 8 weeks and sacrificed 8 weeks after the last DEN injection. They were also fed on 8% BB (w/w) containing chow for 16 weeks. Hepatic damage markers in serum were determined together with hepatic histopathological examinations. Hydroxyproline (HYP), malondialdehyde (MDA), diene conjugate (DC), protein carbonyl (PC), and glutathione (GSH) levels, and CuZn-superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, and their mRNA expressions were measured. Protein and mRNA expressions of glutathione transferase-pi (GST-pi) were evaluated as a marker of preneoplastic lesions. BB supplementation decreased hepatic damage markers in serum and hepatic MDA, DC, and PC levels, but SOD, CAT, and GSH-Px activities and their mRNA expressions remained unchanged in DEN-treated rats. BB attenuated cirrhotic changes and decreased hepatic HYP levels and GST-pi expressions. Our results indicate that BB is effective in decreasing development of DEN-induced hepatic cirrhosis and preneoplastic lesions by acting as an antioxidant (radical scavenger) itself without affecting activities and mRNA expressions of antioxidant enzymes.

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Section: Ishak Stage Gst-pimentioning

confidence: 61%

Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats

Bingül

Başaran-Küçükgergin

Aydın

et al. 2016

Int J Immunopathol Pharmacol

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“…21 Blueberries also reportedly demonstrated antioxidant effects, reduced the accumulation of fat in the aortas and livers of animal models, and reduced cardiovascular risk in obese individuals. [22][23][24][25] It is possible that the biological effects were produced by phytosterols, phenolics, and other bioactive compounds present in blueberries as in bitter yam. 2,16,26 Saponin-induced delay in gastric emptying 15 or other mechanisms of satiating effect may have suppressed the appetite and slightly reduced food intake in rats fed 5% bitter yam or 1% diosgenin supplement in the present study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Jamaican Bitter Yam (Dioscorea polygonoides) and Diosgenin on Blood and Fecal Cholesterol in Rats

McKoy

Thomas

Asemota

et al. 2014

Journal of Medicinal Food

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A sapogenin-rich preparation from Jamaican bitter yam (Dioscorea polygonoides) has been shown to reduce blood cholesterol concentrations in hypercholesterolemic rats and mice. Also, diosgenin supplementation has been reported to have antilipemic effects in several animal species. We investigated potential mechanisms of the lipid-lowering actions of bitter yam and also whether the actions were mediated by diosgenin. Sprague-Dawley rats were fed a hypercholesterolemic diet (4% cholesterol) alone or with 5% bitter yam or 1% diosgenin supplementation for 6 weeks. The control group was fed normal rat chow. The serum lipid profile, fecal cholesterol concentration, and serum lipase activity were assessed at the end of the period. The induction of hypercholesterolemia was inhibited by coadministration of 5% bitter yam or 1% diosgenin in the diet. Serum lipid profiles were similar in rats fed bitter yam or diosgenin. The fecal cholesterol concentration was significantly (P < .01) higher in rats fed diosgenin compared to the cholesterol group. However, there was no corresponding elevation in the group fed bitter yam. Administration of bitter yam or diosgenin supplement significantly increased (P < .01) the serum lipase activity compared to the normal control and cholesterol groups. The cholesterol-supplemented diet inhibited normal gain in body weight over the period. This action was potentiated by diosgenin. The effects of the respective supplements on body weight were not completely explained by food consumption. Supplementation of the diet with Jamaican bitter yam may be therapeutically beneficial in the management of hypercholesterolemia.

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“…It has been reported that BB supplementation caused significant increases in serum total phenolic and anthocyanin levels, together with increased anti‐oxidant activity in human subjects . In the current study, BB concentration was chosen according to previous studies that describe that 5–10% whole fresh BB was an effective concentration . The daily consumption of BB in 5% and 10% BB‐containing diets is roughly equivalent to 0.75 and 1.5 g fresh BB per rat, respectively.…”

Section: Discussionmentioning

confidence: 99%

Blueberry treatment attenuates D‐galactose‐induced oxidative stress and tissue damage in rat liver

Çoban

Betül-Kalaz

Küçükgergin

et al. 2013

Geriatrics Gerontology Int

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Effect of Blueberry Feeding on Lipids and Oxidative Stress in the Serum, Liver and Aorta of Guinea Pigs Fed on a High-Cholesterol Diet

Cited by 30 publications

References 23 publications

Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats

Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats

Effects of Jamaican Bitter Yam (Dioscorea polygonoides) and Diosgenin on Blood and Fecal Cholesterol in Rats

Blueberry treatment attenuates D‐galactose‐induced oxidative stress and tissue damage in rat liver

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