Effect of BMP2–Platelet-rich Plasma–Biphasic Calcium Phosphate Scaffold on Accelerated Osteogenesis in Mastoid Obliteration

Jang, Chul Ho; Choi, Choong Hyeok; Cho, Yong Beom

doi:10.21873/invivo.11002

Cited by 3 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies showed that Escherichia coli-derived rhBMP-2, BMP-2, and PRP enhanced osteogenesis in mastoid obliteration. 9,10 We suggest that ODM is a good option for supplying the nutrients and growth factors necessary for bone formation.…”

Section: Discussionmentioning

confidence: 99%

“…A wide range of growth factors, such as bone morphogenetic protein (BMP), transforming growth factor beta, insulin‐like growth factor, platelet‐derived growth factor, and basic fibroblast growth factor have been applied in bone tissue engineering . BMP‐2 and platelet‐rich plasma (PRP) containing a variety of growth factors are reported to enhance the reconstruction of temporal dorsal bulla bone . However, which growth factors promote mastoid bone formation most efficiently is not yet known.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Osteogenesis for postoperative temporal bone defects using human ear adipose‐derived stromal cells and tissue engineering: An animal model study

Kim

Park

Shin

et al. 2017

J Biomedical Materials Res

View full text Add to dashboard Cite

Mastoidectomy, the removal of infected mastoid bones, is a common surgical procedure for the treatment of chronic otitis media. Persistent and recurrent otorrhea and accumulation of keratin debris following open cavity mastoidectomy are still bothersome issues for both patients and otologists. In this study, we used human ear adipose-derived stromal cells (hEASCs) in combination with polycaprolactone (PCL) scaffolds and osteogenic differentiation medium (ODM) to regenerate temporal bone defects. The hEASCs showed stem cell phenotypes, and these characteristics were maintained up to passage 5. Mastoid bulla and cranial bone defects were induced in Sprague-Dawley rats using AgNO and burr hole drilling, respectively, and the rats were then divided into five groups: (1) control, (2) hEASCs, (3) hEASCs + ODM, (4) hEASCs + PCL scaffolds, and (5) hEASCs + PCL scaffolds + ODM. Osteogenesis was evaluated by micro-computed tomography and histology. Compared with the control group, the groups transplanted with hEASCs and PCL scaffolds had significantly higher bone formation along the periphery of the mastoid bulla area. Moreover, ODM synergistically enhanced bone formation in mastoid bulla defects. Our results suggest that combining hEASCs with PCL scaffolds represents a promising method for anatomical and functional reconstruction of postoperative temporal bone defects following mastoidectomy. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3493-3501, 2017.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Osteogenesis for postoperative temporal bone defects using human ear adipose‐derived stromal cells and tissue engineering: An animal model study

Kim

Park

Shin

et al. 2017

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…(10,11).These materials even more categorically must be covered with connective tissue flaps, perichondrium or cartilage to keep in place and to induce new bone formation. Some authors suggest fibrin glue, platelet reach plasma or similar materials to cover the obliterated area (12,13). Soft tissue flaps as material for mastoid obliteration included Palva muscle-periosteal posterior flap or inferior musculo-fascial pedicle flap.…”

Section: Methodsmentioning

confidence: 99%

Mastoid cavity obliteration in treatment of middle ear cholesteatoma

Rouev

2020

International Bulletin of Otorhinolaryngology

View full text Add to dashboard Cite

The primary goal in the surgical management of chronic otitis media with cholesteatoma is the creation of a dry and safe ear. The method of choice for management of cholesteatoma is the inside out or reverse mastoidectomy. If external auditory canal reconstruction after complete cholesteatoma removal is not possible, mastoid cavity obliteration techniques are recommended to reduce the size of the open mastoid cavity. The goal of our study is to evaluate the frequency of postoperative ear secretion and hearing situation in patients with mastoid cavity obliteration in treatment of middle ear cholesteatoma. Methods: Retrospective study of 155 patients with middle ear cholesteatoma were surgically treatment during 52 months from 01.06.2014 to 30.09.2018 in Hospital Trakia Park, Stara Zagora (Bulgaria) with canal wall reconstruction or mastoid cavity obliteration with cartilage, bone paté or bone replacement alloplastic materials. Results: After complete cholesteatoma removal we perform ear canal reconstruction in 51.61% of cases (80; n=155), and in others 41.94% of cases (65; n=155) we perform mastoid cavity obliteration. In our patient group we perform type I tympanoplasty in 36.77% (57; n=155), type III tympanoplasty in 46.45% (72; n=155), Secondlook operations in 14% (21, n = 155) and only in 5 cases we left the operating cavity open (3.23%; n=155). After mean follow-up period from 11.34 months (1÷48 months; SD 13.10 months) our frequency of postoperative ear secretion is 6.45% (10; n=155) and our cholesteatoma residual rate is 9.03% (14; n=155). Conclusion: Mastoid cavity obliteration procedures can prevent the development of postoperative retraction pockets by isolation the tympanic cavity from the attic and mastoid. This is a safe and effective technique for rehabilitation of mastoid cavities. Hearing results of this technique is variable according to the involvement of the middle ear ossicles, but with the possibility of fitting a hearing aids or middle ear implants.

show abstract

Treatment with platelet- and extracellular vesicle-rich plasma in otorhinolaryngology-a review and future perspectives

Vozel

Božič

Jeran

et al. 2021

Advances in Biomembranes and Lipid Self-Assembly

View full text Add to dashboard Cite

Effect of BMP2–Platelet-rich Plasma–Biphasic Calcium Phosphate Scaffold on Accelerated Osteogenesis in Mastoid Obliteration

Abstract: Abstract.

Cited by 3 publications

References 21 publications

Osteogenesis for postoperative temporal bone defects using human ear adipose‐derived stromal cells and tissue engineering: An animal model study

Osteogenesis for postoperative temporal bone defects using human ear adipose‐derived stromal cells and tissue engineering: An animal model study

Mastoid cavity obliteration in treatment of middle ear cholesteatoma

Treatment with platelet- and extracellular vesicle-rich plasma in otorhinolaryngology-a review and future perspectives

Contact Info

Product

Resources

About