Effect of body mass index on in vitro fertilization outcomes in women

Sathya, Anjali; Balasubramanyam, Sathya; Gupta, Shalu; Verma, Thankam

doi:10.4103/0974-1208.74155

Cited by 41 publications

(33 citation statements)

References 10 publications

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“…In Erel et al, 2009 a literature review was performed difference between patients with different BMI. Zander -Fox et al, 2012, Singh et al, 2012, Vilarino et al, 2011, Bellver et al, 2010and Sathya et al, 2010 have not Sneed et al, 2008, showed that the interaction between however, BMI alone had no apparent effect. This had a greater impact on patients under 36 years, because in older women age became the most important factor.…”

Section: Number Of Oocytes Retrievedmentioning

confidence: 99%

“…One was the study of Veleva et al (2008) , which showed that the BMI graph curve that represents how BMI affects the miscarriage rate is U-shaped, meaning that patients of low weight also has their increased risk, independent of patient age ( Figure 3 ). Moreover, the revision of Rittenberg et al, 2011 revealed increased miscarriage rate in 14 studies (RR 1.36, 95 % CI 1.13 to 1.64, p et al, 2010, despite the rate being increased, this increase was not significant, as in Vilarino et al, 2011, Zhang et al, 2010and Sathya et al .,2010. Sneed et al, 2008 showed that miscarriage rate is not directly affected by BMI, but by the interaction between BMI and age, with age the main determining factor.…”

Section: Miscarriage Ratementioning

confidence: 99%

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Obese women and in vitro fertilization: results

Koatz¹,

Souza²

2013

JBRA Assisted Reproduction

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Objective: To evaluate the effect of female obesity on the results of In Vitro Fertilization (IVF) in six parameters: dose of gonadotropins required, number of oocytes retrieved and fertilization, pregnancy, miscarriage and live births rates. method: Literature search in PUBMED articles in English between 2008 and 2013 using the following keywords: female, obesity and In Vitro Fertilization. 15 articles were selected for this work. Results: From the total only two articles showed that female obesity does not alter the results of IVF. The remaining 13 came to the conclusion that obesity has a negative effect on some of the parameters evaluated. However, there was no consensus about its effect. Conclusion: Further studies are needed to clarify the real role of obesity in female patients undergoing IVF, but the weight loss prior to treatment should always be encouraged. keywords: Female, Obesity and In Vitro Fertilization. RESUmOObjetivo: Avaliar o efeito da obesidade feminina nos resultados da fertilização in vitro (FIV) em seis parâmetros: recuperados e fertilização, gravidez, aborto e taxas de nascidos vivos. método: Inglês, entre 2008 e 2013, utilizando as seguintes palavraschave: mulher, obesidade e fertilização in vitro. 15 artigos foram selecionados para este trabalho. Resultados: Do total apenas dois artigos mostraram que a obesidade feminina não altera os resultados de fertilização in vitro. Os restantes 13 chegaram à conclusão de que a obesidade tem um efeito negativo sobre alguns dos parâmetros avaliados. no entanto, não houve consenso sobre o seu efeito. Conclusão: Mais estudos são necessários para esclarecer o real papel da obesidade em pacientes do sexo feminino submetidas a fertilização in vitro, mas a perda de peso antes do tratamento deve ser sempre incentivada. Palavras-chave: feminino, obesidade e fertilização in vitro.

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Section: Number Of Oocytes Retrievedmentioning

confidence: 99%

Section: Miscarriage Ratementioning

confidence: 99%

Obese women and in vitro fertilization: results

Koatz¹,

Souza²

2013

JBRA Assisted Reproduction

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“…Although studies demonstrated that no change of gonadotropin treatment was implied in different BMI [50,51], there are several studies have argued that higher dosage of gonadotropin and longer treatment duration exhibited in patients with BMI more than 25 kg/m 2 [52,53]. Interestingly, in our results, no significant difference on clinical pregnancy rate was observed by the change of BMI in non-PCOS patients whereas overweight and obese women with PCOS showed significant decrease in clinical pregnancy rate, suggesting BMI may affect the outcome of IVF/ICSI only in PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of Body Mass Index on Outcomes of In Vitro Fertilization/Intracytoplasmic Sperm Injection Among Polycystic Ovarian Syndrome Patients

Cui

Wang

et al. 2016

Cell Physiol Biochem

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Background: The aim of this study is to assess the effect of body mass index (BMI) on outcomes of in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) among polycystic ovarian syndrome (PCOS) and non-PCOS patients. Methods: This was a retrospective cohort study that was performed in the Second Hospital of Hebei Medical University. Patients who were under 35 years old were included in the study and were divided into four groups based on their BMI. The number of retrieved oocytes, implantation rate, clinical pregnancy rate, miscarriage rate and live births among PCOS and non-PCOS patients were compared between different BMIs. Results: IVF/ICSI pregnancies in obese PCOS women had a considerably higher risk of miscarriage and low rate of clinical pregnancy than in non-obese PCOS pregnancies. However, in non-PCOS patient, obesity significantly elevated miscarriage rate but did not affect clinical pregnancy rate. Conclusion: Obesity in PCOS patients led to poor outcomes of IVF/ICSI.

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“…Normal BMI versus BMI 25-29.9 kg/m 2 : pooled analysis from five studies (Dechaud et al, 2006;Esinler et al, 2008;Bellver et al, 2010;Sathya et al, 2010;Zhang et al, 2010) showed a higher dose of gonadotrophin stimulation in women with BMI 25-29.9 kg/m 2 compared with women with normal BMI (WMD 137.92,, P = 0.005). There was a significant heterogeneity between the included studies (I 2 = 61.2%).…”

Section: Dose Of Gonadotrophin Stimulationmentioning

confidence: 99%

Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis

Rittenberg

Seshadri

Sunkara

et al. 2011

Reproductive BioMedicine Online

364

241

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There is conflicting evidence regarding the effect of raised body mass index (BMI) on the outcome of assisted reproductive technology. In particular, there is insufficient evidence to describe the effect of BMI on live birth rates. We carried out a systematic review and meta-analysis of studies to evaluate the effect of raised BMI on treatment outcome following IVF/ICSI treatment. Subgroup analysis on overweight and obese patients was performed. Literature searches were conducted on MEDLINE, EMBASE and the Web of Science from 1966 to 2010. Thirty-three studies including 47,967 treatment cycles were included. Results indicated that women who were overweight or obese (BMI ≥ 25) had significantly lower clinical pregnancy (RR=0.90, P<0.0001) and live birth rates (RR=0.84, P=0.0002) and significantly higher miscarriage rate (RR=1.31, P < 0.0001) compared to women with a BMI < 25 following treatment. A subgroup analysis of overweight women (BMI ≥ 25-29.9) revealed lower clinical pregnancy (RR=0.91, P=0.0003) and live birth rates (RR=0.91, P=0.01) and higher miscarriage rate (RR=1.24, P < 0.00001) compared to women with normal weight (BMI < 25). In conclusion, raised BMI is associated with adverse pregnancy outcome in women undergoing IVF/ICSI treatment, including lower live birth rates. This effect is present in overweight as well as obese women.

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Effect of body mass index on in vitro fertilization outcomes in women

Cited by 41 publications

References 10 publications

Obese women and in vitro fertilization: results

Obese women and in vitro fertilization: results

Impact of Body Mass Index on Outcomes of In Vitro Fertilization/Intracytoplasmic Sperm Injection Among Polycystic Ovarian Syndrome Patients

Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis

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