Effect of bonito insulin on endogenous insulin secretion in dogs

Sando, Hiroyuki; Kanazawa, Yasunori; Kuzuya, T

doi:10.1152/ajplegacy.1970.218.5.1357

Cited by 27 publications

(16 citation statements)

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“…Although insulin, in high doses, might directly suppress insulin secretion [13], low doses, as used in this study, have no effect on insulin secretion if the plasma glucose is kept constant [14]. Fish insulin injected in larger doses to dogs did not reduce insulin secretion [15].…”

Section: Discussionmentioning

confidence: 97%

Glucose control of basal insulin secretion in diabetes

1977

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Summary. The plasma insulin response to both a small increase and decrease in the plasma glucose has been studied in normal and diabetic, non-obese subjects. In a second investigation the plasma insulin concentrations were measured during a gradual reduction of the raised fasting plasma glucose of diabetes to normal levels. In both studies, diabetic patients were found to have a markedly impaired response of the fasting plasma insulin to small changes in plasma glucose. These results do not support the suggestion that stimulated and not basal insulin secretion is impaired in diabetes. Both modes of secretion are probably via the same B-cell release mechanism, which is deficient in diabetes. There was a gradation of response between maturity onset and juvenile onset diabetics.

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Section: Discussionmentioning

confidence: 97%

Glucose control of basal insulin secretion in diabetes

1977

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“…Although there have been several reports suggesting a direct feedback inhibition of insulin by insulin (Best & Haist, 1941;Sodoyez et al, 1964;Logothetopoulos et al, 1965;Sodoyez et al, 1969;Chu & Goodner, 1968;Hellman & Lernmark, 1969;Iversen & Miles, 1971;Hahn & Micheal, 1971) some workers found no inhibition (Grodsky et al, 1968b;Malaisse et al, 1967;Sando et al, 1970) However, in man, it has not yet been documented whether insulin secretion is influenced by the blood level of insulin. In order to investigate any presence of a feedback mechanism of insulin secretion, the effect of prior infusion of bonito insulin upon glucose-induced insulin secretion in man was studied.…”

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confidence: 99%

“…activity to porcine and human insulin (Sando et al, 1970;Berson & Yalow, 1959;Grodsky, 1965;Falkmar & Whson, 1967;Samols & Ryder, 1961;Yalow & Berson, 1964) Thus, it is expected that circulating bonito insulin can be immunologically distinguished from endogenous insulin when administered to man.…”

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confidence: 99%

Effect of Prior Infusion of Exogenous Bonito Insulin on Glucose-Induced Insulin Release in Man

1973

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SynopsisIn order to investigate a possible short feedback mechanism of insulin secretion, the effect of prior infusion of bonito insulin upon glucose-induced insulin secretion in man was studied. The increase in plasma insulin after intravenous injection of a glucose solution was analysed under prior sustaining infusion of bonito insulin at the concentration of 12mU/0.5ml/min and 6mU/0.5ml/min.These concentrations of bonito insulin were shown to have had no effect on the blood sugar levels, nor on the basal insulin levels. After the prior eight hour infusion of exogenous insulin, the increase in glucoseinduced insulin secretion was significantly smaller than that produced after infusion of saline as a control. The magnitude of the inhibition in plasma insulin elevation was more remarkable at the higher dose of insulin. The level of blood sugar after glucose injection shown no significant change.The half-life of immunoreactive insulin in plasma was determined after prior infusion of bonito insulin or saline for three hours. There was not tendency to any difference in T 1/2 between saline treated subjects and subjects who had received the rapid injection of porcine insulin prior to the infusion of bonito insulin.

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“…Grodsky (1968), Malaisse et al (1968) and Sando et al (1970) denied the possibility of a feedback mechanism by which insulin secretion is inhibited by insulin itself. On the other hand there were an equivalent or greater number of contrasting data which pointed to the possible existence of the mechanism (Morgan et al, 1965;Logothetopoulos et al, 1965;Iversen and Miles, 1971;Ziegler et al, 1972;Ohgawara et al, 1973).…”

Section: Notwithstandingmentioning

confidence: 99%

Failure of exogenous insulin to inhibit C-peptide release from the perfused rat pancreas.

et al. 1980

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In order to ascertain whether insulin secretion is inhibited by insulin per se , the effect of exogenous rat insulin on basal and stimulatedrat C-peptide reactivity (CPR) release was studied in the isolated perfused rat pancreas . The pancreas was perfused with a medium containing 20 or 200 ng/ml of rat insulinfor a 20 min equilibration period and successively for a 25 to 30 min test period during which time glucose (300 mg/100 m/), tolbutamide (500 pg/m/), glucagon (500 ng/m/) or arginine (10mm) was added as a secretagogue.

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Effect of bonito insulin on endogenous insulin secretion in dogs

Cited by 27 publications

References 0 publications

Glucose control of basal insulin secretion in diabetes

Glucose control of basal insulin secretion in diabetes

Effect of Prior Infusion of Exogenous Bonito Insulin on Glucose-Induced Insulin Release in Man

Failure of exogenous insulin to inhibit C-peptide release from the perfused rat pancreas.

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