Effect of Bovine Serum Albumin on Redox and Ligand Exchange Reactions Involving Aquacobalamin

High Reactivity of Supermolecular Nanoentities of a Vitamin B12 Derivative in Langmuir–Schaefer Films Toward Gaseous Toxins

“…Aquacobalamin (H 2 OCbl) is a well-known cyanide antidote due to the high affinity of the Co­(III) ion toward this toxin . However, the reaction between H 2 OCbl and CN – has some features that can decrease its efficacy as an antidote, i.e., it is relatively slow in neutral aqueous solutions, and H 2 OCbl forms complexes with biological ligands and proteins , that leads to inhibition of the CN – binding. In contrast to H 2 OCbl, cobinamides (Cbis), nucleotide-free derivatives of Cbls, react with CN – significantly more rapidly, and some Cbi species retain this reactivity in the presence of competitive ligands. , Moreover, Cbis possesses higher water solubility and can be introduced via intramuscular injection .…”