Effect of brain angiotensin II AT1, AT2, and cholinergic receptor antagonism on drinking in water-deprived rats

Lee, Won-jung; Kim, Kyoung-soon; Yang, Eun-Kyoung; Lee, Jung-hyung; Lee, Eun-jung; Park, Jaesik; Kim, Hyeong-Jin

doi:10.1016/0167-0115(96)00063-8

Cited by 24 publications

(12 citation statements)

References 19 publications

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“…(1996) have shown that both losartan and PD 123319 administered into the paraventricular nucleus (PVN) of sodium depleted rats blocked water and sodium intake induced by administration of AII into the same site. Lee et al . (1996) also showed that both AT 1 and AT 2 receptors are involved in AII‐induced drinking in rats deprived of water, while Rowland et al .…”

Section: Discussionmentioning

confidence: 99%

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Central AT₁ and AT₂ receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning

Camara¹,

Osborn²

2001

Acta Physiologica Scandinavica

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Intracerebroventricular (ICV) angiotensin (AIl) administration stimulates central AII receptors to induce water consumption in rats. The aim of this study was to determine the role of brain AT1 and AT2 receptors in mediating chronic ICV AII-induced drinking in rats raised on normal or high sodium chloride diets from weaning. Rats were weaned at 21 days of age and placed on normal or high sodium chloride diet for 10-12 weeks. At adulthood, the animals were instrumented with brain lateral ventricular cannulas and femoral arterial catheters. Low dose chronic central AII infusion (20 ng min(-1)) significantly (P < 0.05) increased water intake in both groups of rats when compared with their respective controls of 24 h artificial cerebrospinal fluid infusions. In a separate group of high sodium fed rats, coinfusion of AII with the AT1 receptor antagonist, losartan (0.25 microg min(-1)) or the AT2 receptor blocker, PD 123319 (0.50 microg min(-1)) blocked chronic ICV AII-induced drinking. Upon reinfusion of AII water intake increased above control. Following the cessation of AII infusions, water intake returned to values not significantly different from control (P > 0.05). In contrast, in the normal sodium fed rats losartan, but not PD 123319, blocked the AII-mediated water intake. The data demonstrate that in high sodium chloride fed rats AII stimulates both central AT1 and AT2 receptors to induce drinking, while in the normal sodium chloride fed rats the peptide activates the drinking response primarily by stimulation of central AT1 receptors.

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Section: Discussionmentioning

confidence: 99%

“…Rowland & Fregly (1993) have also reported that ICV injection of PD 123319, but not losartan, inhibited drinking induced by 24 h water deprivation, hypertonic sodium chloride or hypovolaemia. Furthermore, recent studies by Lee et al . (1996) showed that both AT 1 and AT 2 receptors are involved in dehydration‐induced drinking.…”

mentioning

confidence: 94%

Central AT₁ and AT₂ receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning

Camara¹,

Osborn²

2001

Acta Physiologica Scandinavica

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“…Thus, the reason for the reduced ingestion of water after the blockade of SFO angiotensinergic and cholinergic mechanisms in rats treated with muscimol into the LPBN is probably the reduced ingestion of hypertonic NaCl. Nevertheless, considering the importance of central cholinergic mechanisms for water deprivation- or hyperosmolarity-induced water intake (Block and Fisher, 1970, Lee et al, 1996), in the case of central muscarinic blockade a possible direct effect on the reduction of water intake is also possible.…”

Section: Discussionmentioning

confidence: 99%

Angiotensinergic and cholinergic receptors of the subfornical organ mediate sodium intake induced by GABAergic activation of the lateral parabrachial nucleus

Roncari¹,

David²,

Johnson

et al. 2014

Neuroscience

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Bilateral injections of the GABAA agonist muscimol into the lateral parabrachial nucleus (LPBN) induce 0.3 M NaCl and water intake in satiated and normovolemic rats, a response reduced by intracerebroventricular (icv) administration of losartan or atropine (angiotensinergic type 1 (AT1) and cholinergic muscarinic receptor antagonists, respectively). In the present study, we investigated the effects of the injections of losartan or atropine into the subfornical organ (SFO) on 0.3 M NaCl and water intake induced by injections of muscimol into the LPBN. In addition, using intracellular calcium measurement, we also tested the sensitivity of SFO-cultured cells to angiotensin II (ANG II) and carbachol (cholinergic agonist). In male Holtzman rats with cannulas implanted bilaterally into the LPBN and into the SFO, injections of losartan (1 μg/0.1 μl) or atropine (2 nmol/0.1 μl) into the SFO almost abolished 0.3 M NaCl and water intake induced by muscimol (0.5 nmol/0.2 μl) injected into the LPBN. In about 30% of the cultured cells of the SFO, carbachol and ANG II increased intracellular calcium concentration ([Ca2+]i). Three distinct cell populations were found in the SFO, i.e., cells activated by either ANG II (25%) or carbachol (2.6%) or by both stimuli (2.3%). The results suggest that the activation of angiotensinergic and cholinergic mechanisms in the SFO is important for NaCl and water intake induced by the deactivation of LPBN inhibitory mechanisms with muscimol injections. They also show that there are cells in the SFO activated by both angiotensinergic and cholinergic stimuli, perhaps those involved in the responses to muscimol into the LPBN.

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“…Water deprivation is a standard stimulus used to elicit thirst in animals, with thirst being inferred from the amount of water drunk after the stimulus. These tests have generally been administered during the day 1,2 for reasons of convenience, although rats consume most water at night and in close relationship to meals.…”

Section: Introductionmentioning

confidence: 99%

Time Of Day And Access To Food Alter Water Intake In Rats After Water Deprivation

Ang

McKitrick

Phillips

et al. 2001

Clin Exp Pharma Physio

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1. Drinking behaviour after water deprivation is one of the standard tests used to study thirst in humans and animals. Diurnal cycle and food availability are known to influence water intake, but have not been considered in previous studies of thirst after water deprivation. In the present study, we examined the effects of diurnal variation and food availability on water intake after 24 h water deprivation in rats. 2. All rats cycled through four treatments in varying order. These treatments were: (i) 24 h water deprivation with free access to food from 1900 h one day to 1900 h the next day, followed by free access to both food and water (Night-with-Food); (ii) 24 h water deprivation with free access to food from from 1900 h one day to 1900 h the next day, followed by free access to water but not food (Night-without-Food); (iii) 24 h water deprivation with free access to food from 0700 h one day to 0700 h the next day, followed by free access to both food and water (Day-with-Food); or (iv) 24 h water deprivation with free access to food from 0700 h one day to 0700 h the next day, followed by free access to water but not food (Day-without-Food). The amount of water consumed during the first 6 h, post-24 h water deprivation, was examined under each condition. 3. There was a significant diurnal effect (P < 0.001) and a significant food availability effect (P = 0.007) on the water consumed in the 6 h period after water deprivation. Most water was consumed by the Night-with-Food group and the least amount of water was consumed by the Day-without-Food group. These effects persisted after correction for water intake during 6 h periods from 0700 and 1900 h with and without food but without previous water deprivation. The diurnal and food availability effects on water consumption were independent (P = 0.5). 4. The coefficient of variability for each group suggests that the most sensitive measurements of water intake are obtained during the day in the absence of food. 5. We conclude that both the time of day and access to food independently alter water intake in rats subjected to a previous 24 h water deprivation. Our study also supports the validity of performing water intake measurements in thirst studies in rats during the day.

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Effect of brain angiotensin II AT1, AT2, and cholinergic receptor antagonism on drinking in water-deprived rats

Cited by 24 publications

References 19 publications

Central AT₁ and AT₂ receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning

Central AT₁ and AT₂ receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning

Angiotensinergic and cholinergic receptors of the subfornical organ mediate sodium intake induced by GABAergic activation of the lateral parabrachial nucleus

Time Of Day And Access To Food Alter Water Intake In Rats After Water Deprivation

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Effect of brain angiotensin II AT1, AT2, and cholinergic receptor antagonism on drinking in water-deprived rats

Cited by 24 publications

References 19 publications

Central AT1 and AT2 receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning

Central AT1 and AT2 receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning

Angiotensinergic and cholinergic receptors of the subfornical organ mediate sodium intake induced by GABAergic activation of the lateral parabrachial nucleus

Time Of Day And Access To Food Alter Water Intake In Rats After Water Deprivation

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Central AT₁ and AT₂ receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning

Central AT₁ and AT₂ receptors mediate chronic intracerebroventricular angiotensin II‐induced drinking in rats fed high sodium chloride diet from weaning