Effect of Caffeic Acid Dietary Supplementation on the Antioxidant Defense System in Rat: Anin VivoStudy

Nardini, Mirella; Natella, Fausta; Gentili, Vincenzo; Felice, Maurizio Di; Scaccini, Cristina

doi:10.1006/abbi.1997.9977

Cited by 119 publications

(66 citation statements)

References 19 publications

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“…A number of studies have shown that the caffeic acid and chlorogenic acid present in several plants exhibited hypoglycemic activity and antioxidant properties in experimental animals [29,30,31,32]. The presence of these compounds together with dicaffeoil quinic derivates led us to think that they could be hypoglycemic principles of the decoction.…”

Section: Discussionmentioning

confidence: 99%

Smallanthus macroscyphus: A new source of antidiabetic compounds

Serra-Barcellona

Aráoz

Cabrera

et al. 2014

Chemico-Biological Interactions

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Section: Discussionmentioning

confidence: 99%

Smallanthus macroscyphus: A new source of antidiabetic compounds

Serra-Barcellona

Aráoz

Cabrera

et al. 2014

Chemico-Biological Interactions

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“…In vivo animal models, the physiological relevance of CA through a direct contribution to the antioxidant defense system was demonstrated by Nardini et al (1997). Dietary supplementation of CA (0.2 and 0.8% w/w) in rats resulted in a statistically significant increase of alfa-tocopherol both in plasma and in lipoprotein.…”

Section: Antioxidant Activity Of Hydroxycinnamic Acidsmentioning

confidence: 99%

Anticancer Properties of Hydroxycinnamic Acids -A Review

Rocha¹,

Monteiro²,

Teodoro

2012

CCO

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Hydroxycinnamic acid compounds are an important source of antioxidants due to their ubiquitous occurrence in the plant kingdom and their characteristic activities. Due to their antioxidant activity, several researchers have attributed a probable role of these compounds in the prevention of various diseases associated with oxidative stress, such as cancer and cardiovascular diseases. Recent evidence suggests that these compounds may also act by other mechanisms in addition to the antioxidant capacity as modulating the activity of some specific enzymes and inhibit cell proliferation. This paper is a comprehensive review of the effects of hydroxycinnamic acids on cancer. The review encompasses the occurrence and bioavailability of these compounds evidences for their effects on cancer and the various mechanisms by which may exert their effects. There are several common mechanisms by which these chemicals exert their effects that could be conducive to additive, synergistic, or antagonistic interactions. These include effects on cellular differentiation, proliferation, and apoptosis; effects on proteins and enzymes that are involved in these processes at a molecular level, and other various effects through altered immune function and chemical metabolism.

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“…It has been reported that peak plasma concentrations of phenolic acids from beer were attained 30 and 60 min after beer ingestion (73). A number of works have shown that phenolic acids are not degraded in the gastrointestinal tract prior to absorption (72)(73)(74)(75)(76)(77)(78)(79)(80)(81). Moreover, free phenolic acids are easily released from foods in the gastrointestinal tract by bacterial esterases (82) and directly absorbed, as early as in the proximal part of the small intestine (71,73).…”

Section: Phenolic Acids As Efficient Ache and Bche Inhibitorsmentioning

confidence: 99%

“…Moreover, free phenolic acids are easily released from foods in the gastrointestinal tract by bacterial esterases (82) and directly absorbed, as early as in the proximal part of the small intestine (71,73). After in vivo absorption, phenolic acids are transformed only to a limited extent in comparison to more complex phenolic compounds (73)(74)(75)(76)81). Polyphenols are easily degraded to simple phenolic compounds, yielding phenolic acids that are absorbed into the blood circulation system (79,80,(83)(84)(85).…”

Section: Phenolic Acids As Efficient Ache and Bche Inhibitorsmentioning

confidence: 99%

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Szwajgier

Borowiec

2012

J. Inst. Brew.

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Anticholinesterase activities of mashes produced using wheat ('Wheat Pale') or barley malts ('Pilsner', 'Pale Ale', 'Munich Light', 'Carahell' or 'Carared') were studied by spectrophotometric method. The highest inhibition of acetylcholinesterase and butyrylcholinesterase was observed at 52 C and/or 64 C, followed by a decrease or stabilization of the activity at 72 C. Changes in the total phenolics content in the test mashes were correlated with changes in the acetylcholinesterase and/or butyrylcholinesterase activities. Phenolic acids were singled out from phenolic compounds for more detailed studies owing to their simplicity and structural similarity to well-known cholinesterase inhibitors. The main phenolic acids in the test malts were ferulic, gallic, p-coumaric and vanillic acids followed by chlorogenic, caffeic, syringic, p-OH-benzoic, sinapic and protocatechuic acids. The anticholinesterase activities of the phenolic acids were studied using model standard solutions at concentrations similar to the maximal content of these compounds in the test mashes. Among the phenolic acids, p-coumaric acid had the largest share in the anticholinesterase activity, even though it was present in the test mashes at a significantly lower concentration (~0.38 mM L À1 ) than ferulic acid (~1.00 mM L À1 ). Sinapic acid and p-OH-benzoic acid (0.03 and 0.01 mM L À1 , respectively) were equally efficient inhibitors as ferulic acid at~1.00 mM L À1 . This preliminary study should be extended to other phenolic compounds from malt (wort) in the near future.

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Effect of Caffeic Acid Dietary Supplementation on the Antioxidant Defense System in Rat: Anin VivoStudy

Cited by 119 publications

References 19 publications

Smallanthus macroscyphus: A new source of antidiabetic compounds

Smallanthus macroscyphus: A new source of antidiabetic compounds

Anticancer Properties of Hydroxycinnamic Acids -A Review

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

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