Effect of Caffeine Versus Placebo Supplementation on Blood-Glucose Concentration

Cheraskin, E.; Ringsdorf, W. M.; Setyaadmadja, AlbertusT.S.H.; Barrett, R. A.

doi:10.1016/s0140-6736(67)91593-0

Cited by 42 publications

(15 citation statements)

References 3 publications

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“…In 1924 Labbe Â (Labbe Â & Theodoresco, 1924) described a caffeine-induced reduction of glucose tolerance, followed by observations of other authors. Cheraskin (Cheraskin et al, 1967) found higher blood glucose levels 1 2 , 1 and 2 h after ingestion of 250 mg caffeine compared with placebo. Jankelson (Jankelson et al, 1967) found a shift to the right of the OGTT curve after 2 cups of instant coffee but not after water, and Wachman (Wachman et al, 1970) observed an impaired glucose tolerance after`espresso' but not after decaffeinated coffee.…”

Section: Discussionmentioning

confidence: 95%

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Effects of caffeine on glucose tolerance: A placebo-controlled study

Pizziol

Tikhonoff

Paleari³

et al. 1998

Eur J Clin Nutr

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Objective: The investigation was performed to study the effects of 200 mg oral caffeine on glucose tolerance. Design: Single-blind Latin square with active treatment (caffeine) and placebo. Setting: The University of Padova, Department of Internal Medicine. Subjects: 30 nonsmoking healthy subjects aged 26±32 years who abstained not only from coffee but also from tea, chocolate and cola for 4 weeks and who had given their informed consent. Interventions: A 75 g oral glucose tolerance test (OGTT) was performed after giving caffeine or placebo (highly decaffeinated coffee). Results: The glycaemic curve was normal in all subjects and was similar in the two groups until the second hour; in subjects taking caffeine a shift towards the right was detected at the 2nd, 3rd and 4th hours in comparison to those taking the placebo. Blood insulin levels were comparable after caffeine and after placebo along the entire OGTT. Conclusions: The data suggest that caffeine intake induces a rise in blood glucose levels that is insulin independent. Sponsor:

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Section: Discussionmentioning

confidence: 95%

“…In the few studies conducted several years ago, blood glucose was found to be increased (Labbe Â & Theodoresco, 1924;Cheraskin et al, 1967;Jankelson et al, 1967;Wachman et al, 1970), decreased (Deakins et al, 1939;DeCastro et al, 1969) or unchanged (Denaro et al, 1981;Brown & Benowitz, 1989) after coffee or caffeine administration.…”

Section: Introductionmentioning

confidence: 99%

Effects of caffeine on glucose tolerance: A placebo-controlled study

Pizziol

Tikhonoff

Paleari³

et al. 1998

Eur J Clin Nutr

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“…Roasting of coffee can transform some of the chlorogenic acid into quinides, which have been shown to enhance insulin action in rats [17]. Caffeine acutely lowered insulin sensitivity [18,19,20,21,22] and increased glucose concentrations [23,24,25,26,27] in short-term metabolic studies in humans. However, these effects may not persist during chronic coffee consumption [19], and beneficial effects of caffeine on insulin sensitivity [28] and glucose-induced insulin secretion [29] have also been suggested.…”

Section: Introductionmentioning

confidence: 99%

Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study

Dam¹,

et al. 2004

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Aims/hypothesis. Coffee contains several substances that may affect glucose metabolism. The aim of this study was to evaluate the relationship between habitual coffee consumption and the incidence of IFG, IGT and type 2 diabetes. Methods. We used cross-sectional and prospective data from the population-based Hoorn Study, which included Dutch men and women aged 50-74 years. An OGTT was performed at baseline and after a mean follow-up period of 6.4 years. Associations were adjusted for potential confounders including BMI, cigarette smoking, physical activity, alcohol consumption and dietary factors. Results. At baseline, a 5 cup per day higher coffee consumption was significantly associated with lower fasting insulin concentrations (−5.6%, 95% CI −9.3 to −1.6%) and 2-h glucose concentrations (−8.8%, 95% CI −11.8 to −5.6%), but was not associated with lower fasting glucose concentrations (−0.8%, 95% CI −2.1 to 0.6%). In the prospective analyses, the odds ratio (OR) for IGT was 0.59 (95% CI 0.36-0.97) for 3-4 cups per day, 0.46 (95% CI 0.26-0.81) for 5-6 cups per day, and 0.37 (95% CI 0.16-0.84) for 7 or more cups per day, as compared with the corresponding values for the consumption of 2 or fewer cups of coffee per day (p=0.001 for trend). Higher coffee consumption also tended to be associated with a lower incidence of type 2 diabetes (OR 0.69, CI 0.31-1.51 for ≥7 vs ≤2 cups per day, p=0.09 for trend), but was not associated with the incidence of IFG (OR 1.35, CI 0.80-2.27 for ≥7 vs ≤2 cups per day, p=0.49 for trend). Conclusions/interpretation. Our findings indicate that habitual coffee consumption can reduce the risk of IGT, and affects post-load rather than fasting glucose metabolism.

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“…In healthy male subjects, no change occurred in the fasting blood glucose concentration following coffee ingestion [6], but with pure caffeine, a hyperglycaeinic effect was apparent [7]. Patients with maturity onset diabetes, given intravenous glucose, also showed an increase in blood glucose after drinking coffee [8].…”

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confidence: 99%

The Effect in Volunteers of Coffee and Decaffeinated Coffee on Blood Glucose, Insulin, Plasma Lipids and Some Factors Involved in Blood Clotting

et al. 1970

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The effect of coffee-drinking on blood composition was studied in 20 healthy volunteers who normally consumed, on average, 560 mg caffeine/day from tea and coffee. After 14 days on decaffeinated coffee (12 mg caffeine/day) there was a reduction in blood glucose, a small rise in plasma cholesterol and phospholipid, and a more substantial fall in triglycerides. The substitution of coffee for decaffeinated coffee (875 mg caffeine/day) for 20 days did not affect blood glucose, but the changes in the plasma lipids were reversed. There was no change in the level of immunoreactive insulin, in platelet adhesiveness, fibrinogen or blood clot lysis time during the course of the experiment. The part played by caffeine and by coffee solids other than caffeine in the induction of these changes does not support the hypothesis that the consumption of coffee is a significant factor in the development of coronary heart disease.

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Effect of Caffeine Versus Placebo Supplementation on Blood-Glucose Concentration

Cited by 42 publications

References 3 publications

Effects of caffeine on glucose tolerance: A placebo-controlled study

Effects of caffeine on glucose tolerance: A placebo-controlled study

Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study

The Effect in Volunteers of Coffee and Decaffeinated Coffee on Blood Glucose, Insulin, Plasma Lipids and Some Factors Involved in Blood Clotting

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