2022
DOI: 10.3390/microorganisms10061242
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Effect of Caging on Cryptosporidium parvum Proliferation in Mice

Abstract: Cryptosporidiosis is an enteric infection caused by several protozoan species in the genus Cryptosporidium (phylum Apicomplexa). Immunosuppressed mice are commonly used to model this infection. Surprisingly, for a pathogen like Cryptosporidium parvum, which is readily transmitted fecal-orally, mice housed in the same cage can develop vastly different levels of infection, ranging from undetectable to lethal. The motivation for this study was to investigate this phenomenon and assess the association between the … Show more

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Cited by 1 publication
(7 citation statements)
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“…Because of the potential for caging conditions to affect the course of cryptosporidiosis 15 , 20 , in this study we included only individually caged animals. The goals of these analyses were twofold; the first set of analyses focused on the entire dataset of 108 samples collected between day − 3 post-infection and the end of each experiment.…”
Section: Resultsmentioning
confidence: 99%
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“…Because of the potential for caging conditions to affect the course of cryptosporidiosis 15 , 20 , in this study we included only individually caged animals. The goals of these analyses were twofold; the first set of analyses focused on the entire dataset of 108 samples collected between day − 3 post-infection and the end of each experiment.…”
Section: Resultsmentioning
confidence: 99%
“…Such interventions could act on enterocytes but also on goblet cells to promote mucin secretion. The goal of the experiments described here and published previously 15 aim to identify molecular mechanisms explaining the interaction between microbiota metabolism and the course of cryptosporidiosis. To distinguish between cause and effect, microbiota collected no later than 3 days post-infection were analyzed separately from samples collected later in the experiment.…”
Section: Discussionmentioning
confidence: 99%
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