Effect of calcium against weight gain and improved histopathologic fatty liver on male Wistar rats that fed high fat food

Hidayat, Meilinah; Prahastuti, Sijani; Tiono, Hartini; Dianawati, D.A.; Marcella,

doi:10.1016/j.orcp.2013.08.051

Cited by 3 publications

(2 citation statements)

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“…Although they slightly intensified the hepatoprotective effects of each other on HFFr diet-induced steatosis and hepatic cholesterol accumulation, but not on the increased serum liver enzymes levels and hepatic lipid peroxidation. These results are consistent with the findings of some earlier studies which have demonstrated the protective effects of each of metformin, 10 , 11 calcium 16 or 1,25 (OH) 2 vitamin D 3, 17 separately, and CaD 54 against the development of steatosis in animal models.…”

Section: Resultssupporting

confidence: 93%

“…There is now some evidence that vitamin D could be a natural insulin sensitizer, especially in combination with calcium. 13 , 14 Dietary calcium or VitD 3 (cholecalciferol) intake, as well as calcitriol administration have been shown to prevent adiposity, insulin resistance 14 , 15 and hepatic fatty changes 16 , 17 and to be related to AMPK activation in different tissues in animal models. 18 , 19 On the other hand, Shalata et al .…”

Section: Introductionmentioning

confidence: 99%

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The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease

et al. 2018

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Purpose: Metformin is one of the most popular drugs tested against nonalcoholic fatty liver disease (NAFLD). The present study aimed to investigate whether calcium-vitamin D3 cosupplementation will intensify the effect of metformin on the prevention of high-fat, high-fructose (HFFr) diet-induced hepatic steatosis.Methods: Male wistar rats (210±16 g) were assigned into the following seven groups: a Control group to receive a standard chow and six HFFr-fed groups to receive diets containing either normal (0.5% calcium and 1000 IU/kg vitamin D3) or high amount of calcium and vitamin D3 (2.4% calcium and 10000 IU/kg vitamin D3) (CaD), in combination with gastric gavage administration of either saline or 25 or 200 mg/kg body weight/day metformin. After 60 days, rats were assessed with respect to their anthropometric, metabolic and hepatic parameters, as well as their hepatic AMP-activated protein kinase (AMPK) phosphorylation.Results: Metformin and CaD, either alone or in combination, caused a significant reduction in HFFr diet-induced high serum aspartate aminotransferase (AST), hepatic steatosis and lipid accumulation without effect on insulin resistance and AMPK phosphorylation. In addition, slightly (and non-significantly) better effects of the combination in ameliorating steatosis and hepatic cholesterol content were observed.Conclusion: Taken together, our results suggest that metformin and CaD could protect against the onset of HFFr diet-induced NAFLD in an insulin and AMPK-independent manner, without any marked additional benefits of their combination.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease

et al. 2018

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Calcium and vitamin D3 combinations improve fatty liver disease through AMPK-independent mechanisms

2016

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Ekstrak Kedelai Detam 1, Daun Jati Belanda Serta Kombinasinya Terhadap Berat Badan Dan Histopatologis Hepar Tikus Wistar

Hidayat

Soeng

Wahyudianingsih

et al. 2015

JKKI

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ABSTRAK Latar BelakangBiji kedelai Detam 1 dan daun jati Belanda berefek menghambat kenaikan berat badan, akan tetapi dikhawatirkan mempengaruhi organ hepar. Tujuan penelitianTujuan penelitian untuk mengetahui efek ekstrak etanol biji kedelai Detam 1 (EEKD), ekstrak etanol daun jati Belanda (EEJB) dan kombinasinya terhadap penghambatan kenaikan berat badan dan gambaran histopatologis hepar pada tikus Wistar yang diberi pakan tinggi lemak (PTL). Metode penelitianPenelitian merupakan eksperimental laboratorium dengan rancangan acak lengkap bersifat komparatif. Sebanyak 40 ekor tikus Wistar jantan dibagi secara acak menjadi 8 kelompok perlakuan, masing masing terdiri dari 5 ekor. Selanjutnya diberi perlakuan selama 28 hari, semua kelompok kecuali kelompok kontrol negatif (KN), tetap diberi PTL. Pada hari ke-29, seluruh tikus dikorbankan dan semua hepar tikus, kecuali kelompok Orlistat (K6), dibuat sediaan histopatologis dengan pewarnaan Haematoxylin Eosin (HE). HasilPenghambatan kenaikan berat badan terjadi pada semua kelompok perlakuan, kelompok K3 (EEKD 10 mg : EEJB 20 mg) menunjukkan penghambatan kenaikan berat badan yang paling baik dan potensinya setara dengan kontrol positip (KP) atau Orlistat. Pada semua kelompok perlakuan (K1, K2, K3, K4 dan K5) terjadi perubahan struktur arsitektur dan inflamasi di daerah portal namun tidak menyebabkan bengkak keruh dan degenerasi lemak.Kesimpulan: Pemberian kombinasi EEKD 10 mg : EEJB 20 mg menunjukkan penghambatan kenaikan berat badan yang paling baik. EEJB sediaan tunggal menyebabkan perubahan gambaran histopatologis hepar paling buruk pada tikus Wistar jantan yang diinduksi pakan tinggi lemak.

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Effect of calcium against weight gain and improved histopathologic fatty liver on male Wistar rats that fed high fat food

Cited by 3 publications

References 0 publications

The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease

The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease

Calcium and vitamin D3 combinations improve fatty liver disease through AMPK-independent mechanisms

Ekstrak Kedelai Detam 1, Daun Jati Belanda Serta Kombinasinya Terhadap Berat Badan Dan Histopatologis Hepar Tikus Wistar

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