Background: Anti-Nutritional-Factors (ANF) are natural or synthetic compounds that interfere with the absorption of nutrients. ANF may cause changes in the histopathology of the small intestinal mucosa, and may affect the digestive, secretory and absorptive functions of the small intestine. Soybean and Jati Belanda leaves which can promote weight loss, may contain ANF. In this study, soybean seeds variety Detam 1 and Jati Belanda leaves were used to assess their potential effects on weight gains and jejunum functions. Research Objective: To study the effects of ethanol extracts of Detam 1 raw soybean (EEDS) and Jati Belanda (EEJB) Bumi Herbal Dago variety and their combinations on weight gain and jejunum histopathological changes in male Wistar rats. Research Methods: Phytochemical analyses of EEDS and EEJB ethanol extracts were performed, then assayed for the above mentioned activities after administered to high-fat induced male Wistar rats for 28 days. Weight gain was determined and histopathological examination of jejunum was achieved after fixation and staining with Hematoxylin Eosin. Results: The combinations of EEDS:EEJB (2:1 and 1:2 w/w) reduced the weight gain with the effect being more pronounced (5.95%) for the combination 1:2 (w/w). Such effect may be attributed to ANFs contained in EEDS and EEJB such as tannin, saponin, flavonoids and phenolics. The histopathologic examination of the positive control group was not different from all treatment groups (p>0.05). Conclusion: The combination EEDS:EEJB (1:2 w/w) is effective in inhibiting weight gain without remarkable histopathological changes in male Wistar rat jejunum.

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Gangguan saluran cerna yang sering dialami pasien adalah kembung. Kembung ialah gejala yang menunjukkan adanya udara dalam usus. Kunyit/Curcuma longa L., dan Rimpang kencur/Rhizoma Kaempfria galanga L., secara empirik memiliki efek karminatif. Penelitian ini bertujuan untuk membandingkan efek karminatif antara ekstrak etanol kunyit (EEK) dengan ekstrak etanol rimpang kencur (EERK) dengan parameter peningkatan motilitas usus. Penelitian menggunakan desain Rancangan Acak Lengkap (RAL) dengan lingkup penelitian laboratorium ekperimental sungguhan.  Hewan coba yang digunakan adalah 30 ekor mencit jantan galur Swiss Webster dan dibagi dalam 6 kelompok (n=5), kelompok 1 EEK dosis 7mg/20gBB  mencit, kelompok 2 EEK 14mg/20gBBmencit, kelompok 3 EERK 7mg/20gBB mencit, kelompok 4 EERK 14mg/20gBB mencit), kelompok 5 sebagai kontrol pembanding (sediaan merk ‘TA’) 0,39ml/20gBB mencit, dan kelompok 6 sebagai kontrol negatif (larutan CMC1%) 0,5 ml. Parameter yang diukur adalah motilitas usus yang dinilai dari rasio panjang usus yang dilalui norit dibandingkan panjang usus seluruhnya. Hasil menunjukkan terdapat perbedaan bermakna antara EEK dosis 1 (85,80%) EEK dosis 2 (89,36%) dan EERK dosis 1 (86,08%) EERK dosis 2 (90,04%) dengan kontrol negatif (CMC1% (76,27%)) dan berbeda tidak bermakna dengan kontrol pembanding (90,14%). Simpulan, EEK, EERK, dan kontrol pembanding mempunyai efek karminatif yang setara dalam meningkatkan motilitas usus mencit galur Swiss Webster.   Kata kunci:  Kunyit; Rimpang Kencur; Karminatif; Motilitas Usus

Ulcerative colitis is a chronic inflammatory disease mainly affects sigmoid colon and rectum. The inflammation process will activate NF-κB and leads to proinflamatory cytokine release such as Interleukin-6 (IL-6). Fig leaves contain a high level of flavonoid which can prevent NF-κB activation, and further inhibits IL-6 secretion. This research aims to see the preventive effect of methanolic extract of fig leaves towards colon histopathological feature and IL-6 serum level on ulcerative colitis induced mice. Balb/C male mice were randomly assigned into 5 groups (n=5). The treatment groups were dextran suphate sodium (DSS) control group (group I), methanolic extract of Fig leaves dose 28 mg/ day control group (group II), and methanolic extract of Fig leaves dose 7 mg/ day (group III), 14 mg/ day (group IV), and 28 mg/ day (group V) for 14 days, which at the 8th till 14th day were given DSS to induce colitis. The results showed that both of colon mucosal damage and IL-6 serum level of group I were significantly different from other groups (p=0,029). In  conclusion, the methanolic extract of Fig leaves can improve colon mucous damage and decrease IL-6 serum level on ulcerative colitis-induced mice. Keywords: ulcerative colitis, fig leaves, colon mucousal damage, interleukin-6