Effect of calcium channel blockers on the serum levels of thyroid hormone

Kaur, Rimple Jeet; Mehta, Bharati; Ambwani, Sneha; Gehlot, Anusuya

doi:10.5455/2319-2003.ijbcp20130824

Cited by 3 publications

(3 citation statements)

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“…Additionally, higher circulating levels of T3 and/or T4 were correlated with higher LVM index and RWT among 293 hypertensive Japanese patients and 2078 middleaged EAs untreated for hypertension (Iida et al, 2012;Roef et al, 2013). Interestingly, daily use of nifedipine, a dCCB decreased T3 and T4 circulating levels on male albino rabbits during 3 months of treatment (Kaur, Mehta, Ambwani, & Gehlot, 2013). Additionally, thyroid hormone disorders can affect the synthesis and secretion of renin-angiotensin system (RAS) components (Ichihara, Kobori, Miyashita, Hayashi, & Saruta, 1998;Santos & Ferreira, 2007;Vargas, Rodriguez-Gomez, Vargas-Tendero, Jimenez, & Montiel, 2012).…”

Section: Discussionmentioning

confidence: 99%

Genome‐wide meta‐analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans

Zhao

Baldridge

et al. 2019

Molec Gen & Gen Med

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BackgroundLeft ventricular (LV) hypertrophy affects up to 43% of African Americans (AAs). Antihypertensive treatment reduces LV mass (LVM). However, interindividual variation in LV traits in response to antihypertensive treatments exists. We hypothesized that genetic variants may modify the association of antihypertensive treatment class with LV traits measured by echocardiography.MethodsWe evaluated the main effects of the three most common antihypertensive treatments for AAs as well as the single nucleotide polymorphism (SNP)‐by‐drug interaction on LVM and relative wall thickness (RWT) in 2,068 participants across five community‐based cohorts. Treatments included thiazide diuretics (TDs), angiotensin converting enzyme inhibitors (ACE‐Is), and dihydropyridine calcium channel blockers (dCCBs) and were compared in a pairwise manner. We performed fixed effects inverse variance weighted meta‐analyses of main effects of drugs and 2.5 million SNP‐by‐drug interaction estimates.ResultsWe observed that dCCBs versus TDs were associated with higher LVM after adjusting for covariates (p = 0.001). We report three SNPs at a single locus on chromosome 20 that modified the association between RWT and treatment when comparing dCCBs to ACE‐Is with consistent effects across cohorts (smallest p = 4.7 × 10−8, minor allele frequency range 0.09–0.12). This locus has been linked to LV hypertrophy in a previous study. A marginally significant locus in BICD1 (rs326641) was validated in an external population.ConclusionsOur study identified one locus having genome‐wide significant SNP‐by‐drug interaction effect on RWT among dCCB users in comparison to ACE‐I users. Upon additional validation in future studies, our findings can enhance the precision of medical approaches in hypertension treatment.

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Section: Discussionmentioning

confidence: 99%

Genome‐wide meta‐analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans

Zhao

Baldridge

et al. 2019

Molec Gen & Gen Med

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“…[9] A decrease in Thyroid hormone levels has been observed in male Albino rats on administration of Calcium channel blockers for three months. [10] We here present a case report of calcium channel blocker induced hypothyroidism.…”

Section: Introductionmentioning

confidence: 89%

A Case Report of Calcium Channel Blocker Induced Subclinical Hypothyroidism

Desireddy¹,

Gungam²,

Kondaveti³

et al. 2015

jebmh

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“…T3, free T4, TSH levels will be checked through Electro-Chemiluminescence Immunoassay (ECLIA) and TRH by ELISA kit. 16…”

Section: Groupmentioning

confidence: 99%

Effect of Carbamazepine on the serum level of Thyrotropin Releasing Hormone

Kalsoom

Ali

2019

Int J Basic Clin Pharmacol

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Background: The thyroid gland is endocrine gland located in front and lower side of neck. Thyroid gland secretes two types of thyroid hormones that are triiodothyronine (T3) and tetraiodothyronine (T4). The hypothalamus is a center for regulation of thyroid hormones. It senses the low hormone levels and in turn releases thyrotropin-releasing hormone (TRH). TRH stimulates anterior pituitary to release TSH which then acts on the thyroid gland to maintain normal level of T3 and T4. The objective of study is to determine the effects of carbamazepine on TRH in euthyroid rabbits.Methods: An experimental study performed on 30 rabbits. These were divided into three groups having 10 rabbits in each group. 10 rabbits were treated with 10mg/kg/day of CBZ (OD), other 10 with 35mg/kg/day CBZ (three divided doses) and 10 rabbits served as control. T3, FT4, TSH and TRH levels were evaluated at baseline and after 21 days of treatment in all three groups by Electro-chemiluminescence immunoassay and ELISA respectively.Results: Comparison of the hormone levels of the group and the group having a dose of 10 mg/kg/day 21 days of treatment. Comparative results showed serum level of T3 (P=0.031), FT4 (P=0.030), and TRH (P=0.044) levels significantly lower than the control group and TSH (P=0.057) levels remain unaltered. It was also found that group having a dose of 35 mg/kg/day; TDS showed decrease in T3 (P value 0.001), FT4 (P=0.001), TSH (P=0.003) and TRH (P=0.001) level as compared to control group.Conclusions: Our data suggest that Carbamazepine monotherapy does alter thyroid hormones and its central regulatory hormone TRH. Decrease in TRH level increase level of depression and suicidal thoughts and also risk of tertiary hypothyroidism. These findings could have very important clinical implications.

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Effect of calcium channel blockers on the serum levels of thyroid hormone

Cited by 3 publications

References 10 publications

Genome‐wide meta‐analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans

Genome‐wide meta‐analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans

A Case Report of Calcium Channel Blocker Induced Subclinical Hypothyroidism

Effect of Carbamazepine on the serum level of Thyrotropin Releasing Hormone

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