Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and memory in streptozotocin-induced diabetic rats

Moradkhani, Shirin; Salehi, Iraj; Abdolmaleki, Somayeh; Komaki‬, Alireza

doi:10.4103/0257-7941.157160

Cited by 30 publications

(11 citation statements)

References 33 publications

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“…This result is consistent with the results reported by Ramesh and Pugalendi (21) and Erenmemisoglu et al (22). Moreover, our results indicated oral administration of both doses of the extract resulted in a significant reduction of blood glucose level which is consistent with the results reported previously (10,11).…”

Section: Discussionsupporting

confidence: 93%

“…There are several reports about the antidiabetic effect of the leaf extract of Calendula officinalis (10,11) and a study conducted by Preethi et al has shown an extract of Calendula officinalis flower has significant antioxidant activity in vitro and in vivo (7). However, to the best of our knowledge, there is no report about the effect of its flower's extract on diabetes and insulin secretion from isolated islets in the animal model.…”

Section: Introductionmentioning

confidence: 99%

“…It is also commonly known as Pot Marigold and its flowers have been used for the treatment of inflammatory conditions in internal organs, gastrointestinal ulcers, dysmenorrhea and as a diuretic and diaphoretic in convulsions (6). C. officinalis has been reported to possess several pharmacological activities, which include antioxidant (7,8) anti-inflammatory (9), antidiabetic (10,11), antibacterial (12), and anti-pyretic, cytotoxic as well as tumor reducing (13). This plant is rich in several classes of chemical compounds including terpenoids, flavonoids, coumarins, flavoxanthin, glycosides, volatile oil, sterols, and steroids (8).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Hydroalcoholic Flower Extract of Marigold (Calendula officinalis) on the Biochemical and Histological Parameters in STZ-Induced Diabetic Rats

Ebrahimi

Kheirollah

Mansouri

et al. 2019

Jundishapur J Nat Pharm Prod

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Background: Calendula officinalis, an aromatic plant and rich of various chemical compounds, has been widely used in folk medicine for the treatment of different diseases. Objectives: We investigated the effects of hydroalcoholic flower extract of Calendula officinalis on the biochemical and histological parameters in STZ-induced diabetic rats. Methods: Thirty-six male Wistar rats were divided into four groups: healthy control, diabetic control, diabetic treated with 250 and 500 mg/kg of the hydro-alcoholic extract, respectively. The biochemical and histological measurements were assessed by standard methods. Results: The oral administration of the hydroalcoholic extract of marigold flower resulted in a recovery of body weight and significantly decreased fasting blood sugar (FBS) (P < 0.05). Alanine aminotransferase (ALT), albumin and total bilirubin concentration were significantly recovered after treatment with the extract (P < 0.05). Measurement of homeostasis model assessment for β-cell function (HOMA-β) indicated that the reduction of serum insulin concentration after treatment with the extract may be due to the recovery of beta cell function. Moreover, the extract induced insulin secretion from the rat's isolated pancreatic islets under a glucose-stimulated condition in a dose-dependent manner. The STZ-induced complications on the pancreas, kidneys, and liver were improved after treatment with the extract. Conclusions: Our findings suggest that the potential protective effects of marigold flower extract against the diabetic-induced complications may be mediated by its effect on the reduction of blood glucose and its direct effect on the glucose-stimulated insulin secretion.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Hydroalcoholic Flower Extract of Marigold (Calendula officinalis) on the Biochemical and Histological Parameters in STZ-Induced Diabetic Rats

Ebrahimi

Kheirollah

Mansouri

et al. 2019

Jundishapur J Nat Pharm Prod

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“…The habituation trial was replicated after 30 min. The acquisition trial was conducted 30 min later, in which the guillotine door was closed, and a constant current shock (50 Hz, 1.2 mA) ( Moradkhani et al, 2015 ) was applied for 2 s ( Khodamoradi et al, 2015 ; Ganji et al, 2017 ) immediately after the rat entered the dark chamber. The rat was remained in the device and experienced a foot shock every time it returned to the dark chamber.…”

Section: Methodsmentioning

confidence: 99%

Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

Etaee

Rezvani-Kamran

Komaki

et al. 2021

Front. Behav. Neurosci.

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Little is known about the effects of methamphetamine (Meth) and buprenorphine (Bup) on memory and learning in rats. The aim of this investigation was to examine the impact of Meth and Bup on memory and learning. Fourteen male Wistar rats weighing 250–300 g were assigned to four groups: Sham, Meth, Bup, and Meth + Bup and were treated for 1 week. Spatial learning and memory, avoidance learning, and locomotion were assessed using the Morris water maze, passive avoidance learning, and open field tests, respectively. Meth and Bup impaired spatial learning and memory in rats. Co-administration of Meth + Bup did not increase the time spent in the target quadrant compared to Meth alone in the MWM. The Bup and Meh + Bup groups were found with an increase in step-through latency (STLr) and a decrease in the time spent in the dark compartment (TDC). Meth and Bup had no effects on locomotor activity in the open field test. Bup showed a beneficial effect on aversive memory. Since Bup demonstrates fewer side effects than other opioid drugs, it may be preferable for the treatment of avoidance memory deficits in patients with Meth addiction.

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“…The retention test was conducted 24 hours following PAL acquisition (27,(31)(32)(33). The animals were located in the light chamber, similar to PAL acquisition, and after five seconds, the door was lifted, and the latency to enter the dark chamber (step-through latency; STL) and time spent in the dark chamber (TDC) were reported for up to 300 seconds.…”

Section: Retention Testmentioning

confidence: 99%

Effect of a hydro-alcoholic extract of Melissa officinalis on passive avoidance learning and memory

Dehbani

Komaki‬

Etaee

et al. 2019

J Herbmed Pharmacol

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The results of this study revealed that Melissa officinalis can enhance learning and memory in the passive avoidance test. The high levels of phenols and flavonoids in M. officinalis extracts may be responsible for its beneficial effects.Introduction: Melissa officinalis (MO) or lemon balm is traditionally used as a sedative and anti-spasm herbal medicine. There is also evidence that this plant has effects on learning and memory. This study examined the effect of a hydro-alcoholic extract of MO on passive avoidance learning (PAL) and memory in male rats. Methods: A total of 40 adult male Wistar rats were randomly distributed into four groups (200 to 220 g; n = 10 per group); three dose groups (50, 100, and 200 mg/kg of the hydro-alcoholic extract of MO) and vehicle control (saline) group. Saline or doses of extract were administered daily for 14 days by oral gavage. The rats were trained to enter the shuttle box to record their behavior in the PAL task. A retrieval test was performed 24 hours following training. Results: A significant difference was seen in performance among MO groups and the control. MO administered animals had a decreased number of acquisition trials (P < 0.05). In the retention task, MO administered animals had an increased step-through latency (SLT) (P < 0.01), and a decreased latency in the dark compartment (P < 0.001) compared to the control group. Conclusion: The results of the study show that MO can improve learning and memory in the PAL task. Further investigation is needed to enhance our understanding of the neurobiological mechanisms of the MO extract and its effects on learning and memory.

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Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and memory in streptozotocin-induced diabetic rats

Cited by 30 publications

References 33 publications

Effects of Hydroalcoholic Flower Extract of Marigold (Calendula officinalis) on the Biochemical and Histological Parameters in STZ-Induced Diabetic Rats

Effects of Hydroalcoholic Flower Extract of Marigold (Calendula officinalis) on the Biochemical and Histological Parameters in STZ-Induced Diabetic Rats

Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

Effect of a hydro-alcoholic extract of Melissa officinalis on passive avoidance learning and memory

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