Effect of Carbohydrate Diet Type upon Obesity and Hyperlipemia in the Zucker fa/fa Rat

Abstract

20 fa/fa Zucker rats were submitted to a normalization of their food-intake energy level by pair-feeding using control Fa/- rats, for 4 weeks. Two diets were tested. The first was a starch-based diet (A) (66% starch w/w) and the second a sucrose-based diet (S) (66% sucrose w/w). The food-intake levels and the efficiency of storage of energy were thus comparable for the two diets. Though the fa/fa hyperinsulinemia decreased for the 4 weeks of experiment and was comparable with the (S) and (A) diets, the hypertriglyceridemia was lower with the (S) diet than that for the (A) diet. This could be in relation to the increased post-heparin lipase activity in the (S) diet, compared to the (A) diet.

Dietary Induction Of Hepatic Glucose-6-Phosphate Dehydrogenase, 6-Phosphogluconate Dehydrogenase, And Malic Enzyme In Lean And Obese Female Zucker Rats

“…Increased hepatic lipogenic enzyme activities appear to be important in the development of liver steatosis and excessive body fat, both in genetic and environmental obesity (3)(4)(5)(6). Rat hepatic glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) have been shown to be highly susceptible to dietary alterations.…”