Effect of carbonated drink on excisional palatal wound healing: A study on Wistar rats

Suragimath, Girish; Krishnaprasad, Krupa; Moogla, Srinivas; Sridhara, Sudheendra Udyavara; Raju, Shashidara

doi:10.4103/0970-9290.70789

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…Their results revealed a decrease in lamellipodia formation and a decreased proliferative activity of fibroblasts leading to delay in wound closure. A study conducted by Suragimath et al 30 supported the delay in fibroblast proliferation. Since the optimal pH required for viability and activity of the fibroblasts has been reported to be 7.2 to 7.5, a pH below 3.0 created by carbonated drinks would hinder fibroblast proliferation, thus delaying the normal wound healing process 31 .…”

Section: Disscussionmentioning

confidence: 91%

“…A study done by Sirsat 34 supports this finding and stated that stress or irritation caused by diet can lead to mucosal changes and hinder with the normal healing pattern. A previous study conducted by Suragimath et al 30 on the effects of carbonated drinks on palatal wound healing showed a disruption in wound healing by appearance of necrosis in the area. However, in the present study no signs of necrosis were seen in any of the animals, only epithelial changes were seen.…”

Section: Disscussionmentioning

confidence: 94%

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Histological Effects of Carbonated Drinks on Oral Submucosal Healing in Albino Wista Rats

Fahim

Ahmed

Ashraf

et al. 2015

Pak Postgrad Med J.

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Objective: In this study the effects of carbonated drinks on the healing process of oral submucosa of albino wistar rats were evaluated. Design: This study comprised of 24 adult albino wistar rats which were randomly assigned to a experimental group 1 and an experimental group 2. A circular wound of 3.0 mm was created on the buccal mucosa of each albino wistar rat at day 0. Animals in control group were fed with chow pellet and water while those in experimental group were fed with chow pellet and a commercially available carbonated drink instead of water. 6 animals from each group were sacrificed by decapitation under deep anesthesia at day 7 and 21. The tissue dissected from buccal area was serially sectioned and stained with Haematoxylin & Eosin stains. Wound site was histologically assessed for differences in the healing pattern of submucosa; inflammatory cell count and neovascularization between two groups. Results: There was a marked difference in the healing pattern between the two groups. Animals in group-1 showed a normal healing pattern with formation of a fibrous connective tissue at the end of day-21. In the group-2, there is altered healing phenomenon at the end of the experiment with a subsequent delayed inflammatory reaction at day-21 Conclusion: These findings suggest that consumption of carbonated drinks can disrupt oral wound healing. The contents in carbonated drinks have a proinflammatory action on the soft tissue.

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Section: Disscussionmentioning

confidence: 91%

Section: Disscussionmentioning

confidence: 94%

Histological Effects of Carbonated Drinks on Oral Submucosal Healing in Albino Wista Rats

Fahim

Ahmed

Ashraf

et al. 2015

Pak Postgrad Med J.

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Effect of carbonated drinks on wound healing of oral epithelium

Fahim

Ilyas

Jafari³

et al. 2016

Journal of Oral Biology and Craniofacial Research

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Oral wound healing models and emerging regenerative therapies

Toma

Fuller

Willett

et al. 2021

Translational Research

118

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Following injury, the oral mucosa undergoes complex sequences of biological healing processes to restore homeostasis. While general similarities exist, there are marked differences in the genomics and kinetics of wound healing between the oral cavity and cutaneous epithelium. The lack of successful therapy for oral mucosal wounds has influenced clinicians to explore alternative treatments and potential autotherapies to enhance intraoral healing. The present in-depth review discusses current gold standards for oral mucosal wound healing and compares endogenous factors that dictate the quality of tissue remodeling. We conducted a review of the literature on in vivo oral wound healing models and emerging regenerative therapies published during the past twenty years. Studies were evaluated by injury models, therapy interventions, and outcome measures. The success of therapeutic approaches was assessed, and research outcomes were compared based on current hallmarks of oral wound healing. By leveraging therapeutic advancements, particularly within in cell-based biomaterials and immunoregulation, there is great potential for translational therapy in oral tissue regeneration.

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Effect of carbonated drink on excisional palatal wound healing: A study on Wistar rats

Abstract: Consumption of carbonated drinks can disrupt oral wound healing. Results suggest that the bone changes seen in experimental group samples are not mediated by osteoclasts, and acidity of the carbonated drinks could be one of the reasons for these changes.

Cited by 6 publications

References 2 publications

Histological Effects of Carbonated Drinks on Oral Submucosal Healing in Albino Wista Rats

Histological Effects of Carbonated Drinks on Oral Submucosal Healing in Albino Wista Rats

Effect of carbonated drinks on wound healing of oral epithelium

Oral wound healing models and emerging regenerative therapies

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