Effect of carbonated drinks on wound healing of oral epithelium

Fahim, Ayesha; Ilyas, Muhammad Sharjeel; Jafari, Fahim Haider; Farzana, Fauzia

doi:10.1016/j.jobcr.2015.08.005

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…The intensive inflammation of the underlying lamina propria decreased with the presence of few inflammatory cells. These results were consistent with Fahim et al (38) who created a circular wound of 3.0 mm diameter on the buccal mucosa of rats. On post-wound day 7, they observed a significant increase in the thickness of the regenerating epithelium with fibroblasts, collagen fibers, blood vessels and inflammatory cells in the underlying lamina propria.…”

Section: Discussionsupporting

confidence: 92%

Wound healing and anti inflammatory effects of propolis in critical size defect of rat buccal mucosa (Histochemical and Immuno histochemical study)

Kamel¹,

Younis

Morsy³

2019

Egyptian Dental Journal

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Objectives: the aim of this study is to evaluate the healing and anti-inflammatory effects of propolis in critical wound defects in rats ' buccal mucosa. Subjects& methods: 20 adult male albino rats of average weight 150-250 grams were used. Rats were divided into 2 groups Group I: consists of 10 rats, which were subdivided into 2 sub groups Sub Group I A: consists of 5 rats, the wounds were left un treated for 3 days Sub Group I B: consists of 5 rats, the wounds were left un treated for 7 days Group II: Consists of 10 rats which were subdivided into 2 sub groups Sub Group II A: consists of 5 rats, the wounds were treated with propolis for 3 days Sub Group II B: consists of 5 rats, the wounds were treated with propolis for 7 days The wounds were examined histologically, histochemically and immunohistochemically Results: Histologiacally, histochemical and immunohistochemical results showed that the healing process was faster in propolis treated rats due to anti inflammatory and anti oxidant effects of Propolis. Immunohistochemical labeling of vimentin in propolis treated groups was higher than un treated groups Conclusion: Propolis could improve wound healing by stimulating the proliferation of epithelial cells; and fibroblast proliferation, thus improving wound closure and decreasing inflammation (as prolonged inflammation and the release of inflammatory cytokines could cause tissue damage)

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Section: Discussionsupporting

confidence: 92%

Wound healing and anti inflammatory effects of propolis in critical size defect of rat buccal mucosa (Histochemical and Immuno histochemical study)

Kamel¹,

Younis

Morsy³

2019

Egyptian Dental Journal

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“…Carbonated beverages have ingredients that cause soft tissue inflammation. According to the findings of Ayesha et al, the epithelial changes, inflamed soft tissue and edema observed in experimental group, may be the result of constant irritation from carbonated beverages' acidic and fizzy nature 11,12 .…”

Section: Js Ren Et Al Conducted a Large Prospectivementioning

confidence: 91%

Chronic Inflammatory Changes In Esophageal Mucosa of Albino Rats Following Prolonged Intake of Carbonated Drinks.

Asif

Mazhar

Parveen

et al. 2022

ashkmdc

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Abstract Background: Carbonated beverages include soft drinks or sodas which contain carbondioxide and that when ingested for prolonged period of time lowers the intra-esophageal pH and can lead to histopathological changes in the mucosa. Objective: To study the effects of prolonged intake of carbonated drinks on the oesophagus of albino rats. Method: This experimental study was carried out at Shaheed Mohtarma Benazir Bhutto Medical College for a period of six months. Seventy five rats of wistar strain (gender non specific) were divided into ‘control groups ‘A1 n=10, A2 n=10, A3 n=10 & ‘exposed groups’ B n=15, C n=15 and D n=15.The controls and the exposed animals were fed the same balanced diet, prepared at the lab’s kitchen. The fluid intake of exposed animals was restricted to carbonated drinks only, whereas, the controls were fed water.At the end of the first, third and sixth months, groups A1&B, A2&C and A3&D were sacrificed and histological section of oesophagus were obtained for histomorphological studies. Results: On micrometry, width of the oesophagus of the exposed animals for one month;Group B was higher (17.87) than those of Group A1 (5.70). Those rats sacrificed at the end of the third month; Group C had significantly enlarged wall thickness of the oesophagus compared to A2 group. The average oesophageal wall thickness 13.60?m was found to be more in the exposed group ‘D’, as compared to 4.50?m measured in Control Group A3 (p<0.01). Conclusion: Prolonged consumption of carbonated drinks resulted in gross and histomorphological changes in the esophageal mucosa. The results of this research will help provide awareness to the general public of the adverse effects afflicted by these beverages.

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“…On day 0, all animals were anesthetized with ketamine (100 mg/kg body weight) and xylazine (10 mg/kg body weight) by an intra-peritoneal injection [17][18][19] . A uniform piece of tissue was removed from the left buccal mucosa of the rest of the rats of both groups, using a disposable punch biopsy tool of 3.0 mm circumference.…”

Section: Extraction Wound Modelmentioning

confidence: 99%

“…A uniform piece of tissue was removed from the left buccal mucosa of the rest of the rats of both groups, using a disposable punch biopsy tool of 3.0 mm circumference. The cut was made deep to the level of the dermis 17,19 . The wound was left open for healing and all the animals were returned to their cages to recover from anesthesia.…”

Section: Extraction Wound Modelmentioning

confidence: 99%

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Histological Effects of Carbonated Drinks on Oral Submucosal Healing in Albino Wista Rats

Fahim

Ahmed

Ashraf

et al. 2015

Pak Postgrad Med J.

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Objective: In this study the effects of carbonated drinks on the healing process of oral submucosa of albino wistar rats were evaluated. Design: This study comprised of 24 adult albino wistar rats which were randomly assigned to a experimental group 1 and an experimental group 2. A circular wound of 3.0 mm was created on the buccal mucosa of each albino wistar rat at day 0. Animals in control group were fed with chow pellet and water while those in experimental group were fed with chow pellet and a commercially available carbonated drink instead of water. 6 animals from each group were sacrificed by decapitation under deep anesthesia at day 7 and 21. The tissue dissected from buccal area was serially sectioned and stained with Haematoxylin & Eosin stains. Wound site was histologically assessed for differences in the healing pattern of submucosa; inflammatory cell count and neovascularization between two groups. Results: There was a marked difference in the healing pattern between the two groups. Animals in group-1 showed a normal healing pattern with formation of a fibrous connective tissue at the end of day-21. In the group-2, there is altered healing phenomenon at the end of the experiment with a subsequent delayed inflammatory reaction at day-21 Conclusion: These findings suggest that consumption of carbonated drinks can disrupt oral wound healing. The contents in carbonated drinks have a proinflammatory action on the soft tissue.

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Effect of carbonated drinks on wound healing of oral epithelium

Cited by 6 publications

References 12 publications

Wound healing and anti inflammatory effects of propolis in critical size defect of rat buccal mucosa (Histochemical and Immuno histochemical study)

Wound healing and anti inflammatory effects of propolis in critical size defect of rat buccal mucosa (Histochemical and Immuno histochemical study)

Chronic Inflammatory Changes In Esophageal Mucosa of Albino Rats Following Prolonged Intake of Carbonated Drinks.

Histological Effects of Carbonated Drinks on Oral Submucosal Healing in Albino Wista Rats

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