Effect of carboxylated carbon nanotubes on physicochemical and drug release properties of oleogels

Qureshi, Dilshad; Nadikoppula, Akhila; Mohanty, Biswaranjan; Anis, Arfat; Cerqueira, Miguel A.; Varshney, Mayank; Pal, Kunal

doi:10.1016/j.colsurfa.2020.125695

Cited by 12 publications

(18 citation statements)

References 54 publications

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“…On the contrary, the K d values were reduced significantly in SA10 from the control, supporting the sustained Fickian release. The values of K r were reduced ( p < 0.05) in SA10 and SP10 from the control, suggesting a negligible role of matrix relaxation for the curcumin release in these cases [ 43 ]. In all the samples, the K d values were higher than the K r values, which supported the significant contribution of Fickian diffusion to relaxation-mediated diffusion toward the observed nutrient release from the oleogels.…”

Section: Resultsmentioning

confidence: 99%

Effects of Sorbitan Monostearate and Stearyl Alcohol on the Physicochemical Parameters of Sunflower-Wax-Based Oleogels

Bharti

Kim

Banerjee

et al. 2022

Gels

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A rising health concern with saturated fatty acids allowed researchers to look into the science of replacing these fats with unsaturated fatty acids. Oleogelation is a technique to structure edible oil using gelators. The present study looked for the effect of solid emulsifiers; namely, sorbitan monostearate (SP) and stearyl alcohol (SA), on the physicochemical parameters of oleogels. All the oleogels were formulated using 5% sunflower wax (SW) in sunflower oil (SO). The formulated oleogels displayed irregular-shaped wax crystals on their surface. The bright-field and polarized microscopy showed the fiber/needle network of wax crystals. Formulations consisting of 10 mg (0.05% w/w) of both the emulsifiers (SA10 and SP10) in 20 g of oleogels displayed the appearance of a dense wax crystal network. The SP and SA underwent co-crystallization with wax molecules, which enhanced crystal growth and increased the density and size of the wax crystals. The XRD and FTIR studies suggested the presence of a similar β’ polymorph to that of the triacylglycerols’ arrangement. The incorporation of SA and SP in wax crystal packing might have resulted in a lower crystallization rate in SA10 and SP10. Evaluation of the thermal properties of oleogels through DSC showed better gel recurrence of high melting enthalpy. These formulations also displayed a sustained release of curcumin. Despite the variations in several properties (e.g., microstructures, crystallite size, thermal properties, and nutrient release), the emulsifiers did not affect the mechanical properties of the oleogel. The meager amounts of both the emulsifiers were able to modulate the nutrient release from the oleogels without affecting their mechanical properties in comparison to the control sample.

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Section: Resultsmentioning

confidence: 99%

Effects of Sorbitan Monostearate and Stearyl Alcohol on the Physicochemical Parameters of Sunflower-Wax-Based Oleogels

Bharti

Kim

Banerjee

et al. 2022

Gels

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“…Many edible oils like wheat germ oil (WGO), safflower oil, flaxseed oil, olive oil, sesame oil, grapeseed oil, soybean oil, algal oil, palm oil, salmon oil, and combinations are most commonly used in OG preparations. 5 From the oils mentioned above, WGO is vibrantly suitable in developing healthy, safe, and nutritive OGs. 5 Wheat germ is a by-product of wheat milling that can produce up to 10% oil, which can be separated mechanically or chemically.…”

Section: Introductionmentioning

confidence: 99%

“… 5 From the oils mentioned above, WGO is vibrantly suitable in developing healthy, safe, and nutritive OGs. 5 Wheat germ is a by-product of wheat milling that can produce up to 10% oil, which can be separated mechanically or chemically. Alternative techniques such as supercritical fluid fractionation and molecular distillation can be used instead of conventional refining to improve the nutritional quality of the oil.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Novel Oleogels Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin

et al. 2022

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Oleogels (OGs) have gained a lot of interest as a delivery system for a variety of pharmaceuticals. The current study explains the development of jasmine floral wax (JFW) and wheat germ oil (WGO)-based OGs for oral drug (curcumin) delivery application. The OGs were made by dissolving JFW in WGO at 70 °C and cooling it to room temperature (25 °C). The critical gelation concentration of JFW that induces the gelation of WGO was found to be 10% (w/w). The OGs were characterized using various techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), microscopic analysis, and mechanical test. XRD data indicated that JFW influences the crystallinity of the OGs. Among the prepared OGs, OG 17.5 showed higher crystallization in the series. Optical microscopic studies demonstrated the formation of fiber structures due to the entanglement of crystals whereas, polarized light micrographs suggested the formation of spherulites or clustered crystallite structures. The mechanical properties of the OGs increased linearly with the increase in the JFW concentration. Curcumin-loaded OGs were examined for their controlled release applications. In summary, the developed OGs were found to have the necessary features for modulating the oral delivery of curcumin.

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“…The oleogels entrap oils within a network structure of the gelators, which are hydrophobic. One of the common types of gelators are vegetable waxes (e.g., mango butter, cocoa butter, sunflower wax, and candelilla wax) [ 18 , 19 , 20 ]. Vegetable wax-based oleogels are prepared by the direct dispersion method, which is one of the most common and easiest methods of oleogel preparation [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Vegetable wax-based oleogels are prepared by the direct dispersion method, which is one of the most common and easiest methods of oleogel preparation [ 21 ]. Since vegetable waxes are rich in fat molecules, fat crystals are formed within the gelator network of oleogels during the synthesis process [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin

Shaikh

Anis

Poulose

et al. 2022

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Bigels are biphasic semisolid systems that have been explored as delivery vehicles in the food and pharmaceutical industries. These formulations are highly stable and have a longer shelf-life than emulsions. Similarly, cellulose-based hydrogels are considered to be ideal for these formulations due to their biocompatibility and flexibility to mold into various shapes. Accordingly, in the present study, the properties of an optimized guar gum hydrogel and sesame oil/candelilla wax oleogel-based bigel were tailored using date palm-derived cellulose nanocrystals (dp-CNC). These bigels were then explored as carriers for the bioactive molecule moxifloxacin hydrochloride (MH). The preparation of the bigels was achieved by mixing guar gum hydrogel and sesame oil/candelilla wax oleogel. Polarizing microscopy suggested the formation of the hydrogel-in-oleogel type of bigels. An alteration in the dp-CNC content affected the size distribution of the hydrogel phase within the oleogel phase. The colorimetry studies revealed the yellowish-white color of the samples. There were no significant changes in the FTIR functional group positions even after the addition of dp-CNC. In general, the incorporation of dp-CNC resulted in a decrease in the impedance values, except BG3 that had 15 mg dp-CNC in 20 g bigel. The BG3 formulation showed the highest firmness and fluidity. The release of MH from the bigels was quasi-Fickian diffusion mediated. BG3 showed the highest release of the drug. In summary, dp-CNC can be used as a novel reinforcing agent for bigels.

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Effect of carboxylated carbon nanotubes on physicochemical and drug release properties of oleogels

Cited by 12 publications

References 54 publications

Effects of Sorbitan Monostearate and Stearyl Alcohol on the Physicochemical Parameters of Sunflower-Wax-Based Oleogels

Effects of Sorbitan Monostearate and Stearyl Alcohol on the Physicochemical Parameters of Sunflower-Wax-Based Oleogels

Preparation and Characterization of Novel Oleogels Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin

Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin

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