Effect of carotid endarterectomy on brain damage markers

Iłżecki, Marek; Iłżecka, Joanna; Przywara, Stanisław; Terlecki, Piotr; Grabarska, Aneta; Stepulak, Andrzej; Zubilewicz, Tomasz

doi:10.1111/ane.12607

Cited by 3 publications

(4 citation statements)

References 41 publications

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“…Каротидная эндартерэктомия (КЭЭ) -метод профилактики ИИ [41]. Цель вмешательстваостановить эмболизацию нестабильной бляшкой каротидной бифуркации, которая является наиболее распространенным патогенным механизмом церебральной ишемии из-за атеросклероза сонных артерий.…”

Section: каротидная эндартерэктомия: до и послеunclassified

“…YKL-40 также является биомаркером повреждения головного мозга при различных неврологических заболеваниях, включая болезнь Альцгеймера, менингит, травму головного мозга и глиому головного мозга. Это означает, что YKL-40 может быть ценным неинвазивным маркером повреждения головного мозга после КЭЭ [41].…”

Section: каротидная эндартерэктомия: до и послеunclassified

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Biomarkers of Carotid Stenosis

Sсherbak

Григорьевич²,

Kamilova

et al. 2021

Physical and rehabilitation medicine, medical rehabilitation

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Early recognition of rupture-prone atherosclerotic lesions in patients with high-graded carotid stenosis is an important clinical problem for preventing ischemic stroke. Various pathophysiological mechanisms are responsible for the progression and instability of plaques, such as changes in lipid composition, infiltration by immunoinflammatory cells and degradation of the extracellular matrix of the vascular wall by matrix metalloproteinases, enhanced inflammatory response and plaque neovascularization. These features are the main cause of plaque rupture and, as a consequence, neurologic symptoms. Therefore, matrix metalloproteinases and inflammatory factors can serve as possible markers for patients with severe unstable stenosis of carotid arteries. Due to the heterogeneity of atherosclerotic lesions, only one biomarker is not enough to reliably predict the development of a stroke. The use of a combination of biomarkers is better correlated with clinical data and, therefore, exceeds the analysis of individual factors. To increase the overall sensitivity and specificity and more reliable diagnosis of stroke in patients with symptomatic and asymptomatic carotid stenosis, the biomarker panel should include independent biomarkers. Further preclinical experiments and clinical trials are needed to assess the significance and precise definition of the threshold levels of such biomarkers before they can be used in clinical practice.

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Section: каротидная эндартерэктомия: до и послеunclassified

Biomarkers of Carotid Stenosis

Sсherbak

Григорьевич²,

Kamilova

et al. 2021

Physical and rehabilitation medicine, medical rehabilitation

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“…YKL-40 также является фактором риска повторных острых нарушений мозгового кровообращения в раннем послеоперационном периофизическая и реабилитационная медицина, медицинскаяреабилитация май 2019 де после каротидной эндартерэктомии и биомаркером повреждения головного мозга при различных неврологических заболеваниях, включая болезнь Альцгеймера, менингит, черепно-мозговую травму и глиому головного мозга. Это означает, что YKL-40 может быть ценным неинвазивным маркером повреждения головного мозга после КЭА [59].…”

Section: биомаркеры атеросклерозаunclassified

Biomarkers of Cardiovascular Disease

Scherbak

Григорьевич²,

Лисовец

et al. 2019

Physical and rehabilitation medicine, medical rehabilitation

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Inflammation, cardiac remodeling, and fibrosis are potentially important pathways in the pathogenesis of cardiovascular diseases. Complications of atherosclerosis are one of the leading causes of death in the world. Effective prevention of cardiovascular disease by adequate control of major cardiovascular risk factors can provide substantial public health gains. However, detection and control of major cardiovascular risk factors continues to be a major challenge because of poor awareness of an individual's status. A solution to this problem is important for an early identification and appropriate correction of cardiovascular risk factors. Atherosclerotic plaque development is regarded as a chronic inflammatory process which involves interactions between lipids, immune cells and the artery wall. Numerous evidence suggests that inflammation plays an important role in all stages of the atherosclerotic process. The study of associations of inflammatory biomarkers has led to the idea that the panel of inflammatory biomarkers can identify people at high risk of developing atherosclerosis and cardiovascular diseases when anti-inflammatory treatment can prevent further unfavorable events. The most common forms of cardiovascular diseases are caused by atherosclerosis, the progressive thinning of blood vessels due to accumulation of lipids within the arterial wall. While many factors are known to influence the development and progression of atherosclerosis, circulating levels of cholesterol and lipoprotein complexes are the most important risk factors and mediators of atherosclerotic disease. Key regulators of lipid metabolism and/or the development of atherosclerosis have diagnostic, prognostic and therapeutic potential for cardiovascular diseases.

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“…Nonetheless, these observations suggest that even uncomplicated embolization of a brain aneurysm may be associated with structural damage to the brain caused by ischemic or inflammatory mechanisms. While studies in interventional radiology refer to endarterectomy procedures or stenting of the external carotid arteries, there are currently no literature data available on the determination of serological biomarkers in terms of brain damage after embolization of intracranial aneurysms for vascular neurosurgery procedures [ 3 , 4 , 5 ]. Therefore, more research is needed to explore this area.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Serum Markers of Perioperative Brain Injury and Inflammation Associated with Endovascular Treatment of Intracranial Aneurysms: A Preliminary Study

Zimny,

Paździora,

Kocur

et al. 2023

Brain Sciences

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Embolization is the preferred method for treating intracranial aneurysms due to its less invasive nature. However, recent findings suggest that even uncomplicated embolization may cause structural damage to the brain through ischemic or inflammatory mechanisms. This study aimed to find possible biomarkers of brain injury and inflammation in patients suffering from intracranial aneurysms who underwent endovascular treatment by measuring serological markers indicating brain damage. The study involved 26 patients who underwent uncomplicated intravascular stenting for unruptured intracranial aneurysms between January 2020 and December 2021. Blood samples were collected before the procedure, at 6–12 h, and at 24 h after the procedure. The following protein biomarkers levels were tested with ELISA: S100B, hNSE, TNF, hsCRP, FABP7, NFL, and GP39. Statistical analysis of the results revealed significant increases in serum levels for the four biomarkers: FABP7—before 0.25 (ng/mL) vs. 6–12 h 0.26 (p = 0.012) and vs. 24 h 0.27 (p < 0.001); GP39—before 0.03 (pg/mL) vs. 6–12 h 0.64 (p = 0.011) and vs. 24 h 0.57 (p = 0.001); hsCRP—before 1.65 (μg/mL) vs. 24 h 4.17 (p = 0.037); NFL—before 0.01 (pg/mL) vs. 6–12 h 3.99 (p = 0.004) and vs. 24 h 1.86 (p = 0.033). These biomarkers are recognized as potential indicators of neurovascular damage and should be monitored in clinical settings. Consequently, serum levels of NFL, GP39, hsCRP, and FABP7 measured before and 24 h after endovascular procedures can serve as important markers for assessing brain damage and indicate avenues for further research on biomarkers of neurovascular injury.

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Effect of carotid endarterectomy on brain damage markers

Cited by 3 publications

References 41 publications

Biomarkers of Carotid Stenosis

Biomarkers of Carotid Stenosis

Biomarkers of Cardiovascular Disease

Analysis of Serum Markers of Perioperative Brain Injury and Inflammation Associated with Endovascular Treatment of Intracranial Aneurysms: A Preliminary Study

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