Effect of caulerpenyne, a toxin extracted fromCaulerpa taxifolia on mechanisms regulating intracellular pH in sea urchin eggs and sea bream hepatocytes

Galgani, Isabelle; Pesando, D.; Porthé-Nibelle, Jacqueline; Fossat, B.; Girard, Jean‐Pierre

doi:10.1002/(sici)1522-7146(1996)11:5<243::aid-jbt5>3.0.co;2-k

Cited by 19 publications

(7 citation statements)

References 31 publications

(47 reference statements)

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“…For example, caulerpenyne, a sesquiterpene from Caulerpa taxifolia, affects embryogenesis, larval development and metamorphosis of the sea urchin Paracentrotus lividus [71,72]. It also interferes with microtubule-dependent events during the first mitotic cycle of sea urchin eggs and affects regulation of intracellular pH in sea urchin eggs and sea bream hepatocytes [73,74].…”

Section: Effects On Fertilization and Larval Developmentmentioning

confidence: 99%

Uses of Seaweed and Its Application to Human Welfare: A Review

Pati

Sharma

Nayak

et al. 2016

Int J Pharm Pharm Sci

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Seaweed research has been carried out for more than seven decades by many research workers. Research has been done separately in different aspects accordingly to our need. The main objective of the present review is to gather information relating to nutritional, pharmacological, clinical, biochemical, industrial uses and its application to human welfare. Seaweeds have a high concentration of essential vitamins, trace elements, proteins, lipids, polysaccharides, enzymes, and minerals as compared to terrestrial foodstuffs. These plants have been a source of food, fodder, medicine, cosmetics, energy, fertilizer and are used for industrial production of agar and alginate. Their recent utilization increases in poultry due to their nutritive value. In the present scenario, it is being used for wastewater treatment such as treatment of wastewater to reduce nitrogen and phosphorus containing compounds. This review work is an attempt to highlights all the relevant application and uses of seaweeds and its products. Finally, this paper would be helpful to a common man to know and aware about such a great living resources which is present in and around us.

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Section: Effects On Fertilization and Larval Developmentmentioning

confidence: 99%

Uses of Seaweed and Its Application to Human Welfare: A Review

Pati

Sharma

Nayak

et al. 2016

Int J Pharm Pharm Sci

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“…A variety of toxic effects due to CYN have been demonstrated, in particular on the sea urchin Paracentrotus lividus, e.g. killing sea urchin eggs (Leme´e et al, 1993), or affecting them via regulation of intracellular pH, and also having effects on embryogenesis, larval development and metamorphosis (Galgani et al, 1996;Pesando et al, 1996Pesando et al, , 1998Smit, 2004). Maximum concentrations of CYN for the 'aquarium-Mediterranean' strain of C. taxifolia were recorded in autumn and a minimum in spring, and reach values that are much higher than are observed in other Caulerpa species (Dumay et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Description of a new marine diatom,Cocconeis caulerpacola sp. nov. (Bacillariophyceae), epiphytic on invasiveCaulerpaspecies

Car

Witkowski

Dobosz

et al. 2012

European Journal of Phycology

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A new species of Cocconeis has been found growing on thalli of the invasive green alga Caulerpa taxifolia collected from the Croatian Adriatic Sea (Bay of Stari Grad, the Island of Hvar, Central Adriatic, Croatia), the coasts of the Mediterranean (Saint Raphae¨l, west of Cannes, France) and the eastern coast of Australia (Moreton Bay, southeast Queensland). Additionally, it was observed on samples of Caulerpa racemosa, another invasive alga in the Mediterranean. Preserved thalli of Caulerpa and cleaned material of the new diatom were studied by light and electron microscopy (SEM and TEM). The morphology and fine structure of the new marine epiphytic diatom, for which we propose the name Cocconeis caulerpacola Witkowski, Car & Dobosz, was determined, including the internal and external structure of the raphe and sternum valve, and the cingulum. Comparison between the new species and three closely related species, C. borbonica, C. diruptoides and C. pseudodiruptoides, was made using material from our samples, as well as material from Vis (Adriatic Sea) obtained from the Hustedt collection. Surprisingly, C. caulerpacola is able to colonize Caulerpa taxifolia in very high abundance, but its occurrence seems to be strongly patchy. Indeed, it seems that C. taxifolia is a suitable host for epiphytic diatoms, in particular this tiny Cocconeis, despite its reputation as a 'killer seaweed'. Cocconeis caulerpacola was observed on Caulerpa species in varying abundance over a wide geographical range.

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“…Several researchers have already focused on observing the chemical effects of CYN: the cytotoxic effects on sea urchins (LEMÉE et al, 1993;GALGANI et al, 1996), antiviral effects on feline immunodeficiency virus (FIV) (NICOLETTI et al, 1999), antiproliferative effects on SK-N-SH cell lines (BARBIER et al, 2001) and on eight human cancer cell lines (FISCHEL et al, 1995) have been reported. The antiproliferative and apoptotic effects were also shown by CAVAS et al (2006).…”

Section: Introductionmentioning

confidence: 99%

Alpha-amylase inhibition kinetics by caulerpenyne

2010

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Many algae have important secretions which are generally used for defensive purposes. These secretions have caught the attention of a number of researchers, as to whether or not these metabolites can be used in medical research. Among these metabolites, caulerpenyne (CYN) which is the main metabolite of the Caulerpa species, has had an important place in Caulerpa research since the beneficial effects related to its determined properties (such as cytotoxic, antiviral, antiproliferative and apoptotic) have been demonstrated in many scientific reports. In the present study, the inhibitory effect of CYN isolated from C. prolifera on alpha-amylase was investigated. The inhibition experiments were done with CYN by a spectrophotometric determination method. In order to evaluate the type of inhibition a Lineweaver-Burk plot was produced. The results obtained from enzyme kinetic studies exhibited a non-competitive type of inhibition, which is characterized by the difference of V max and K M from those of the free enzyme, of alpha-amylase in the presence of CYN. The present study showed that Caulerpa species may be a potential target for the production of diabetic drugs in the light of the results obtained for CYN.

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Effect of caulerpenyne, a toxin extracted fromCaulerpa taxifolia on mechanisms regulating intracellular pH in sea urchin eggs and sea bream hepatocytes

Cited by 19 publications

References 31 publications

Uses of Seaweed and Its Application to Human Welfare: A Review

Uses of Seaweed and Its Application to Human Welfare: A Review

Description of a new marine diatom,Cocconeis caulerpacola sp. nov. (Bacillariophyceae), epiphytic on invasiveCaulerpaspecies

Alpha-amylase inhibition kinetics by caulerpenyne

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