Effect of Ceftriaxone on Isolated Smooth, Cardiac Muscles and Neuromuscular Junctions

Some Pharmacodynamic Aspects of Cefepime

“…These obtained results were similar to the fact that cefeperazone in vivo enhanced the ileal motility in guinea pigs at 62.5 and 125 mg/kg, respectively, and promoted gastrointestinal propulsion of barium sulfate meal in mice at 1000 mg/kg and in vitro enhanced slightly the motility of isolated rabbit's gastrointestinal tract at 0.001 g/mL [ 15 ]. Also these findings were similar to the fact that the spontaneous motility of smooth muscle in situ was temporarily increased with 800 mg/kg cefminox when administered intravenously and in upper doses [ 16 , 17 ]. In contrast, cefadroxil had no effects on the isolated smooth muscle organs and the passage of charcoal meal in mice [ 18 ].…”

The Prospective Effect of Cinnamon and Chia on Submandibular Salivary Glands After Ciprofloxacin Administration in Albino Rats (Histological, Histochemical, and Ultrastructural Study)

“…Whereas, in high dose treated groups (400 mg of CPFX ® /kg/day), necrosis of pancreatic tissue was observed after 7 days of administration. Elsayed et al (2013) studied the effect of CPFX ® on isolated smooth and cardiac muscles and as well as neuromuscular junctions and conclude that CPFX ® acts directly to induce neuromuscular blockade and scarcely possess pharmacological properties which might be leading to sever adverse reaction in clinical use. Moreover, functional and structural damage of rat submandibular and parotid glands was also reported in acute experiments following application of CPFX® and ofloxacin as single intraperitoneal injection at doses of 20, 40, and 80 mg/kg (Abdollahi & Isazadeh, 2001; Abdollahi et al, 2003).…”