Effect of Ceftriaxone versus Amoxicillin + Clavulanic Acid for Treatment of Acute Bacterial Rhino Sinusitis: Short Course Therapy

Al-Saadi, Malath Azeez; Sultan, Safaa Sahib Naji

doi:10.3889/oamjms.2018.329

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Odraslima sa blagom formom bolesti, koji su u prethodnom periodu od 4 nedelje do 6 nedelja lečeni antibioticima i kod odraslih sa srednje teškom formom bolesti preporuka je da se ordinira: amoxicillin/clavulanate, amoxicillin (3 g -3,5 g), cefpodoxime proxetil ili cefixime. Kod odraslih sa srednje teškom formom bolesti, koji su lečeni antibioticima u prethodnom periodu od 4 nedelje do 6 nedelja preporučeni antibiotici za lečenje su: amoxicillin/clavulanate, levofloxacin, moxifloxacin, ili doxycyclin [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] . U našem istraživanju koristili smo levofloxacin u trajanju od 5 dana (500 mg jednom dnevno), levofloxacin u trajanju od 10 dana (500 mg jednom dnevno) i amoksicilin-klavulonat u trajanju od 10 dana (500 mg -125 mg tri puta dnevno), a dobijeni rezultati pokazali su to da ne postoje statistički značajne razlike u pogledu izbora antibiotika i dužine primene terapije.…”

Section: Discussionunclassified

“…Sinusitisi su upale paranazalnih sinusa i mogu biti infektivne, alergijske ili autoimune prirode [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] . Najčešće se javljaju istovremeno sa upalama sluzokože nosne šupljine, te je adekvatniji naziv rinosinusitis 1 .…”

Section: Uvodunclassified

“…Sinusitis represents an inflammation of the paranasal sinuses and it can be infectious, allergic and autoimmune in nature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] . They most often occur simultaneously with the inflammation of the mucous membrane of the nasal cavity, therefore, rhinosinusitis is a more appropriatename 1 .…”

Section: Introductionmentioning

confidence: 99%

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Effects of different antibiotics in the treatment of acute rhinosinusitis

Bojanović¹,

Živković-Marinkov²,

Stamenković³

et al. 2022

Acta stomatologica Naissi

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Introduction: Sinusitis is an inflammation of the paranasal sinuses and it can be infectious, allergic or autoimmune. Acute rhinosinusitis commonly has viral origin and occurs as part of the upper respiratory tract infections. The most common pathogens are Streptococcus, Pneumococcus and Haemophilus influenzae. Some inflammations may start as viral, but develop into bacterial superinfection, i.e., subsequent colonization of the bacteria in 0.5-2% of cases. Viral sinusitis lasts for 7-10 days, whereas bacterial may take longer. The aim: The aim of this study was to compare three therapeutic protocols for the treatment of acute bacterial rhinosinusitis. Materials and Methods: A prospective clinical study was conducted at the Ear, Nose and Throat Clinic, Clinical Center Nis from October 2019 to January 2020, and it involved patients with acute bacterial rhinosinusitis in whom we compared the efficiency and safety of levofloxacin administration for five and 10 days with the efficiency of amoxicillin clavulanate treatment. The study included 62 patients with documented clinical and radiological symptoms. Results: Confirmation of bacterial etiology is not routinely performed in clinical practice since it requires antral puncture or endoscopic examination of the middle nasal meatus. Consequently, the choice of antibiotic therapy is empiric. In our study, we used levofloxacin for five (500 mg once a day) and 10 days (500 mg once a day) and amoxicillin-clavulanatefor 10 days (500 mg-125 mg three times a day), and the results showed no statistically significant difference in regard to the choice of antibiotics and the duration of therapy. Conclusion: The findings of this study suggest that a short course of antibiotic treatment has similar efficiency compared to a longer course of treatment of patients with uncomplicated acute bacterial sinusitis when treatment is indicated.

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Section: Discussionunclassified

Section: Uvodunclassified

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Effects of different antibiotics in the treatment of acute rhinosinusitis

Bojanović¹,

Živković-Marinkov²,

Stamenković³

et al. 2022

Acta stomatologica Naissi

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Amoxicillin/clavulanic acid

2018

Reactions Weekly

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Previous studies have demonstrated that Nocardia brasiliensis is susceptible to amoxicillin-clavulanic acid and that its I8-lactamases are inhibited in vitro by, clavulanic acid. A cardiac transplant patient with disseminated infection caused by N. brasiliensis was treated with this drug combination with good response, but relapsed while still on therapy. The relapse isolate was found to be identical to the initial isolate by using genomic DNA restriction fragment patterns obtained by pulsed field gel electrophoresis, but it was resistant to amoxicillin-clavulanic acid. On isoelectric focusing, the ,I-lactamase from the relapse isolate exhibited a shift in the isoelectric point (pl) of its major band from 5.10 to 5.04 compared with the enzyme from the pretreatment isolate. As determined by using values of the amount of ,-lactamase inhibitor necessary to give 50 5% inhibition of P-lactamase-mediated hydrolysis of 50 FM nitrocefin, the I8-lactamase of the relapse isolate was also 200-fold more resistant than the enzyme from the pretreatment isolate to clavulanic acid and was more resistant to sulbactam, tazobactam, cloxacillin, and imipenem. The I-lactamase of the relapse isolate exhibited a 10-fold decrease in hydrolytic activity for cephaloridine and other hydrolyzable cephalosporins compared with that for nitrocefin. Acquired resistance to amoxicillin-clavulanic acid in this isolate of N. brasiliensis appears to have resulted from a mutational change affecting the inhibitor and active site(s) in the

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Medical and Social Aspects of Acute Rhinosinusitis Treatment

Solomko¹,

Makarenko²

2018

VPBM

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Effect of Ceftriaxone versus Amoxicillin + Clavulanic Acid for Treatment of Acute Bacterial Rhino Sinusitis: Short Course Therapy

Cited by 4 publications

References 24 publications

Effects of different antibiotics in the treatment of acute rhinosinusitis

Effects of different antibiotics in the treatment of acute rhinosinusitis

Amoxicillin/clavulanic acid

Medical and Social Aspects of Acute Rhinosinusitis Treatment

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