Effect of celecoxib plus standard chemotherapy on serum levels of vascular endothelial growth factor and cyclooxygenase-2 in patients with gastric cancer

Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy

“…Previous studies show that Cx reduces serum levels of VEGF and COX-2 (Han et al, 2014). Our results showed that Cx / PLGA reduces VEGF production from a murine mammary tumor.…”

Red ginseng represses hypoxia-induced cyclooxygenase-2 through sirtuin1 activation

“…in combination with chemotherapy, decreased the circulating serum levels of VEGF (Han et al 2014). Although many studies have examined the anti-inflammatory and anti-tumor pharmacological activity of KRG-WE, still continuous research on a detailed mechanism of its effects is necessary.…”

Augmented Activity of Cyclooxygenase‐2 in Tissue and Serum of Patients With Cervical Cancer

“…The studies based on inhibition of Cox-2 demonstrated that its cellular level gets drastically reduced in cancer patients especially when treated with celecoxib-associated CCRT regimens (39). Moreover, blocking of this protein with celecoxib was also shown to inhibit the proliferation of tumor cells through the suppression of VEGF and reduction of serum level of Cox-2 in gastric cancer (40,41). Although the effect of celecoxib on the modulation of Cox-2 level was not examined in this study, ELISA result of Cox-2 may be helpful for monitoring the treatment response in cervical cancer patients undergoing neoadjuvant chemoradiation including selective Cox-2 inhibitors.…”