Effect of Cement Dust Exposure on Phagocytic Function of Polymorphonuclear Neutrophils in Cement Mill Workers

Meo, Sultan Ayoub; Rasheed, Shahzad; Khan, M. Firoze; Shujauddin, Syed; Al-Tuwaijri, Ali S.

doi:10.2478/v10001-008-0017-9

Cited by 13 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One report recently showed decreased phagocytic activity in blood neutrophils stimulated with a stimulant of reactive oxygen species in cement mill workers compared with controls 31. However, information about the exposure, inflammatory cells and soluble markers was not given, and it is difficult to compare our data with this other report.…”

Section: Discussionmentioning

confidence: 59%

Airway inflammation in cement production workers

et al. 2009

View full text Add to dashboard Cite

A significantly higher percentage of neutrophils was observed in cement production workers during the exposed period compared with both the non-exposed period and the external reference group, and corresponded with elevated IL-1beta concentration. These data indicate that cement aerosol exposure in concentrations below the Norwegian occupational limits (respirable dust 5 mg/m(3); total dust 10 mg/m(3)) may cause airway inflammation.

show abstract

Section: Discussionmentioning

confidence: 59%

Airway inflammation in cement production workers

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Exposure to occupations dust has been shown to modulate macrophage function and phagocytosis (Meo et al, 2008;Poole et al, 2009a), therefore we assessed phagocytosis of THP-1 cells cultured in the presence of various concentrations of DE. Fig.…”

Section: ) In That Therementioning

confidence: 99%

Exposure to Swine Housing Dust Modulates Macrophage Morphology and Function

Pender

Minor

Hurley

et al. 2014

American Journal of Immunology

View full text Add to dashboard Cite

Swine Confinement Facility (SCF) dust consists of a complex mixture of feed grain particles, bacterial components, organic particulates and gases. When these particles are inhaled they deposit along the respiratory tract and mediate respiratory symptoms and disease in swine farmers and facility workers. Macrophages ingest and eliminate microbes and debris under chronic conditions; however, the role of macrophages in agricultural-related respiratory disease has not been fully elucidated. The goal was to evaluate the hypothesis that chronic exposure to SCF dust causes inflammation by modulating pulmonary protein levels and macrophage function. Balb/c mice were exposed to 5, 12.5 and 25% SCF Dust Extract (DE) via nebulization 30 min/day five days a week, for eight weeks with weekends excluded. Bronchoalveolar Lavage Fluid (BALF) was collected and analyzed for protein concentration, leukocyte distribution and macrophage morphology. For comparison, THP-1 monocytic cells were exposed to 0.1-10% DE overnight and evaluated for phagocytosis and reactive oxygen species production. Repeated exposure to DE via nebulizer caused a significant increase in protein concentration and inflammatory cell number, namely macrophages, in a dose-dependent manner within the lung as compared to controls. Macrophages with pseudopods and vacuoles were the most abundant leukocytes within BALF of mice exposed to DE. Similarly, in vitro studies with 10% DE treated THP-1 cells revealed enhanced phagocytosis (p<0.05), pseudopodia and vacuolization following exposure to compared to control cells. In addition, there were time-and dose-dependent increases of intracellular ROS production by THP-1 cells exposed to 5 and 10% DE compared to control (p<0.01). These findings indicate repeated, long-term inhalation of swine confinement facility dust may mediate chronic airway and lung inflammation through modulation of protein concentration and macrophage function. The aerosolized dust-mouse inhalation model presented here may offer a good tool for studying particle mediated chronic inflammation of the tracheobronchial tree and lungs.

show abstract

“…Despite these claims, cement manufacturers, marketers and building contractors have continued to deny the health effects of their activities. Their argument is being supported by the fact that most of the studies mentioned above were done on the basis of radiology or spirometry [2] which give rooms for controversy. Because the study organism, man, is mobile and could have developed the diseases from other environmental pollutants such as contaminated water, food etc [3].…”

Section: Introductionmentioning

confidence: 85%

“…Production and usage of cement is a dusty industrial process and the health of the workers have been studied for many years. Silica which is a major constituent of cement dust has been mostly implicated [1][2][3]. Basically, the sections in cement factory can be grouped into crushing, milling and packing sections and each of these sections are known to differ in releasing different toxic constituents [3] with the introduction of various additives and via different mechanical processes [3].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Some Heavy Metals, Electrolytes and Nutritional Status of Masons (Cement Brick Layers) in Uromi, Nigeria

O¹,

GRA²

2018

IJNHS

View full text Add to dashboard Cite

Background: This study determined the effect of exposure to cement on plasma concentrations of heavy metals such as Silicon, Aluminium, and Chromium, electrolytes and the effect on nutritional parameters such as Protein (Albumin and globulin), and Total Cholesterol in the plasma of cement handlers from the study area. Introduction: Production and usage of cement is a dusty industrial process and the health of the workers have been studied for many years and cement dust has been mostly implicated in various associated diseases. Objective: To determine the level of exposure of cement handlers to the heavy metals commonly present in cement by measuring the plasma concentration, to determine the level of lipid peroxidation by cement components by assessment of the total plasma cholesterol and to determine the health implication of prolonged exposure to cement by assessment of nutritional parameters. Design: A total of fourty Masons (Popularly referred to as Bricklayers) were randomly selected for the study and twenty controls who were office workers/students not resident in a town were a cement factory is located, and have never worked as cement handlers. Result: Plasma Aluminium (μg/mL) level was significantly higher for bricklayers of 1-10 years (B1) (0.56 ± 0.08) and bricklayers of >10 years (0.68 ± 0.08), plasma chromium (μg/mL) levels of bricklayers of 1-10 years (0.36 ± 0.06) and bricklayers of >10 years (32 ± 0.05) in comparison with the control (0.31 ± 0.05) was significantly higher. Silicon (μg/mL) levels were not significant for both bricklayers of 1-10 years (0.04 ± 0.05) and bricklayers of >10 years (0.03 ± 0.00). Plasma Magnesium (mmol/l) in comparison with control (0.67 ± 0.11) was significantly higher for bricklayers of 1-10 years (0.76 ± 0.12) and bricklayers of >10 years (0.76 ± 0.07). Plasma Calcium (mg/dl) for bricklayers of 1-10 years (8.62 ± 0.60) was not significant, but significantly higher levels was observed for bricklayers of >10 years (9.99 ± 0.87). Plasma Sodium levels (mmol/l) in comparison with the control (138.30 ± 3.28) was significantly higher for bricklayers of 1-10 years (140.75 ± 2.36), but was statistically not significant for bricklayers of >10 years (139.70 ± 2.64). Potassium (mmol/l) was not signifiant for both groups (3.90 ± 0.21 and 3.91 ± 0.31).Total Protein(g/dl) levels in comparison with control (8.54 ± 1.19) was not significant for both groups..Significantly lower levels of cholesterol (mg/dl) were observed for both groups (138.85 ± 30.07 and 127.00 ± 30.35). Conclusion:The study revealed that some of the heavy metals and other elements present in the composition of cement such as Chromium, Aluminium, Calcium and Magnesium were detected in significantly higher amounts in the test subjects (Bricklayers) in comparison with the control. Lipid peroxidation may have also occurred as a result of the effect of the heavy metals and other components of cement.

show abstract

Effect of Cement Dust Exposure on Phagocytic Function of Polymorphonuclear Neutrophils in Cement Mill Workers

Cited by 13 publications

References 18 publications

Airway inflammation in cement production workers

Airway inflammation in cement production workers

Exposure to Swine Housing Dust Modulates Macrophage Morphology and Function

Assessment of Some Heavy Metals, Electrolytes and Nutritional Status of Masons (Cement Brick Layers) in Uromi, Nigeria

Contact Info

Product

Resources

About