Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain

Roy, Deodutta; Pathak, Deena N.; Singh, Rameshwar

doi:10.1016/0531-5565(83)90031-1

Cited by 39 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased activity brought about by all the antioxidants appears to be indicative of decreased free radical damage resulting in increased reducing potential required for pro tecting the organism against oxidative dam age. These findings support Roy et al [15] who reported an increase in the activity of glutathione reductase in brains of rats fed on centrophenoxine. Later on, in 1984, the au thors [ 16] observed increased glutathione per oxidase activity by feeding chloropromazine to rats.…”

Section: Discussionsupporting

confidence: 82%

Antioxidant- Influenced Alterations in Glutathione Reductase Activity in Different Age Groups of Male Mice

Khanna

Garg²,

Sharma³

1992

Gerontology

View full text Add to dashboard Cite

The glutathione reductase activity was estimated in brain and liver of male mice of different age groups fed on butylated hydroxy anisole (BHA), propyl gallate (PG) and α-tocopherol (TP). A significant increase in glutathione reductase activity was observed with TP during all the phases (pre-reproductive, reproductive and post-reproductive). Antioxidants enhanced the enzyme activity in both the tissues with the exception of BHA in brain during reproductive and PG in liver during pre-reproductive phases respectively. The enhanced reducing potential of the cell in terms of added bioconversion of GSSG to GSH may account for increase in longevity on antioxidant treatment.

show abstract

Section: Discussionsupporting

confidence: 82%

Antioxidant- Influenced Alterations in Glutathione Reductase Activity in Different Age Groups of Male Mice

Khanna

Garg²,

Sharma³

1992

Gerontology

View full text Add to dashboard Cite

show abstract

“…As for GSH-PX, similarly conflicting results have been obtained for age-related changes in GSSG-RD activity (Roy et al, 1983;Vitorica et al, 1984;Mizuno and Ohta, 1986). Catalase may remain stable during aging (Roy et al, 1983;Vitorica et al, t984). Our results on human brain tissue demonstrated significant decrease of each of the enzymes, however, changes occurring in different compartments: the cytosolic SOD and catalase, and the particulate GSH-PX and GSSG-RD activities, declined with age suggesting that the enzymatic protection against oxygen toxicity deteriorates with increasing age.…”

Section: Discussionmentioning

confidence: 89%

“…Mitochondrial GSH-PX in the rat brain has been observed to increase in aged animals (Vitorica et al, 1984). As for GSH-PX, similarly conflicting results have been obtained for age-related changes in GSSG-RD activity (Roy et al, 1983;Vitorica et al, 1984;Mizuno and Ohta, 1986). Catalase may remain stable during aging (Roy et al, 1983;Vitorica et al, t984).…”

Section: Discussionmentioning

confidence: 92%

“…In experimental animals, cytosolic copper-zinc SOD activity has been reported as remaining unaltered (Roy et al, 1983;Danh et al, 1983) or as decreasing with age (Vanella et al, 1982) or as behaving differently in various brain regions (Mizuno and Ohta, 1986). Particulate manganese SOD, however, appears to increase with age (Vanella et al, 1982;Danh et al, 1983;Roy et al, 1983). Cytosolic GSH-PX activity has been noted to remain unaltered (Vitorica et al, 1984), to increase (Mizuno and Ohta, 1986), or to decrease with age (Hothersall et al, 1984).…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Oxygen toxicity protecting enzymes in the human brain

Marttila

Röyttä

Lorentz

et al. 1988

J. Neural Transmission

View full text Add to dashboard Cite

Regional distribution of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities were studied in 22 anatomic sites of 5 human brains. No significant regional differences were observed in cytosolic activities of any enzyme studied, nor in particulate activities of superoxide dismutase, catalase and glutathione reductase, whereas particulate glutathione peroxidase activities were distributed unevenly, the highest activities observed in the basal nucleus and amygdala. There were significant interindividual differences in the activities of each enzyme. This was shown to result partly from the decrease of cytosolic superoxide dismutase and catalase activities with age, concurrently with age-related decrease of particulate glutathione peroxidase and glutathione reductase activities.

show abstract

“…It is also a component of centrophenoxine, a drug widely used for the dissolution of the age pig ment, lipofuscin [Nandy, 1978;Ohtani and Kawashima, 1983], The drug is known to reduce lipofuscin accumulation by elevating the activity of antioxidant enzymes [Roy et al, 1983], A number of phenoxy acids in cluding pCPA inhibit mitochondrial energy transfer reactions in rat liver [Venkaiah and Patwardhan, 1978]. It has been suggested that the action of phenoxy acids is compara ble to that of oligomycin which inhibits oxi dative phosphorylation at all phosphoryla tion sites and hence coupled respiration [Dawson et al, 1969].…”

Section: Discussionmentioning

confidence: 99%

Effect of Malonate and <i>p</i>-Chlorophenoxy Acetic Acid on Hepatic Succinic Dehydrogenase Activity of Ageing Lizards

Jena

Patnaik²

1990

Gerontology

View full text Add to dashboard Cite

The degree of inhibition of hepatic succinic dehydrogenase activity by malonate, a competitive inhibitor, did not differ between young and middle-aged lizards. On the other hand, the same parameter increased significantly between middle-aged and old lizards. The percent inhibition of enzyme activity by p-chlorophenoxy acetic acid was also age-dependent, being higher in middle-aged and old than in young lizards.

show abstract

Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain

Cited by 39 publications

References 32 publications

Antioxidant- Influenced Alterations in Glutathione Reductase Activity in Different Age Groups of Male Mice

Antioxidant- Influenced Alterations in Glutathione Reductase Activity in Different Age Groups of Male Mice

Oxygen toxicity protecting enzymes in the human brain

Effect of Malonate and <i>p</i>-Chlorophenoxy Acetic Acid on Hepatic Succinic Dehydrogenase Activity of Ageing Lizards

Contact Info

Product

Resources

About