Effect of Certain Drugs on Perfused Human Placenta I

Gautieri, Ronald F.; Ciuchta, Henry P.

doi:10.1002/jps.2600510109

Cited by 38 publications

(6 citation statements)

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“…vasculature (1,2,7), it is possible that when such drugs are administered to pregnant women they may disturb the homeostatic conditions of the placenta and exert serious effects on the fetus. Consequently, it is imperative to determine the action of all drugs on placental vasculature.…”

Section: *Recipient Of a Lunsford Richardson Pharmacy Awardmentioning

confidence: 99%

“…Therefore, since it has been shown that 5-hydroxytryptamine (serotonin) (l), sympathomimetics, and histamine (2) constrict placental vessels directly and also that the placental barrier is permeable to substances below a molecular weight of 1000 (3), allowing their passage from maternal to fetal circulation, any condition which actually causes an increased level of these normal body chemicals could, via placental transfer, ultimately lead to teratogenic effects (4), decreased fetal oxygenation (1,2), and even fetal death (5,6).…”

mentioning

confidence: 99%

“…Such drugs include the narcotic analgesics, which cause constriction (morphine, meperidine, and codeine) (1) and certain vasodilators (isosorbide dinitrate, isoproterenol hydrochloride, nitroglycerin, and papaverine) (i). Because some of these agents cross the placental barrier (8, 9) and have been shown in isolated placental preparations to affect directly the placental -.…”

mentioning

confidence: 99%

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Effect of Certain Drugs on Perfused Human Placenta IV

Mancini

Gautieri

1964

Journal of Pharmaceutical Sciences

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Section: *Recipient Of a Lunsford Richardson Pharmacy Awardmentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Effect of Certain Drugs on Perfused Human Placenta IV

Mancini

Gautieri

1964

Journal of Pharmaceutical Sciences

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“…One of the most prominent pharmacolog ical properties of 5-HT is its capability to induce constriction of arterioli and, in conse quence, to cause hypotension and anoxia in the fetus following maternal vasoconstric tion, particularly in the placenta [62][63][64][65][66][67], Insufficient placental blood supply may lead to degeneration of placental tissue and sub sequent abortion of the fetuses.…”

Section: Maternal Pharmacodynamics and Embryonic Developmentmentioning

confidence: 99%

Evaluation of the Teratogenic Potential of Chemicals in the Rat

Fritz

Giese²

1990

Pharmacology

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On the basis of the results of a variety of teratogenicity studies in Sprague-Dawley-derived albino rats, carried out over several years in our laboratory, an appraisal of the principal experimental procedures is set forth. Various categories of chemicals were used for the evaluation of dosage-related teratogenic potency. Salicylate, prednisolone, cyclophosphamide, 5-hydroxytryptamine (serotonin), glycinonitrile, and dimethylformamide have proven to be teratogenic under certain of the experimental conditions used. Particular differences in the embryotropic effects of acetylsalicylic acid were caused by qualitative and quantitative changes of the vehicle. Fetal morphological abnormalities, classified either as ‘malformations’ or as ‘anomalies’, may occur independently of overt maternal toxicity and/or embryotoxicity. Further, they may be closely correlated with general inhibitory effects on growth. Drugs may affect developing tissues and organs selectively due to their pharmacological activity and/or specific organ toxicity. The limitation of maternal treatment to a very short period of gestation may disclose a specific susceptibility of developmental stages of the embryo or fetus. Finally, the importance of data collected from a historical control population to the interpretation of teratogenicity data is emphasised.

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“…They are potent placental vasoconstrictors (1)(2)(3)(4), affect permeability of blood vessels, affect blood pressure, produce some effect on kidney function, and have all been implicated in the production of various pathological states such as carcinoid syndrome, toxemia of burns, pregnancy, and allergy (5-9). They are potent placental vasoconstrictors (1)(2)(3)(4), affect permeability of blood vessels, affect blood pressure, produce some effect on kidney function, and have all been implicated in the production of various pathological states such as carcinoid syndrome, toxemia of burns, pregnancy, and allergy (5-9).…”

mentioning

confidence: 99%