Effect of chemical peeling on the skin in relation to UV irradiation

Abstract

Chemical peeling is one of the dermatological treatments available for certain cutaneous diseases and conditions or improvement of cosmetic appearance of photoaged skin. However, it needs to be clarified whether the repetitive procedure of chemical peeling on photodamaged skin is safe and whether the different chemicals used for peeling results in similar outcomes or not. In this article, we reviewed the effect of peeling or peeling agents on the skin in relation to ultraviolet (UV) radiation. The pretreatment of peeling agents usually enhance UV sensitivity by inducing increased sunburn cell formation, lowering minimum erythematous dose and increasing cyclobutane pyrimidine dimers. However, this sensitivity is reversible and recovers to normal after 1-week discontinuation. Using animals, the chronic effect of peeling and peeling agents was shown to prevent photocarcinogenesis. There is also an in vitro study using culture cells to know the detailed mechanisms of peeling agents, especially on cell proliferation and apoptotic changes via activating signalling cascades and oxidative stress. It is important to understand the effect of peeling agents on photoaged skin and to know how to deal with UV irradiation during the application of peeling agents and treatment of chemical peeling in daily life.

Clinical Evaluation of Glycolic Acid Chemical Peeling in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled, Split-Face Comparative Study

“…Forty percent GA (pH 2.0) peels have consistently been demonstrated to be safe and well tolerated; this patient population had a similar experience. Although sun protection is essential because ultraviolet sensitivity is greater during treatment with GA peels, the chronic effect of GA peeling was shown to prevent photocarcinogenesis in animals . There is also an in vitro study using culture cells to examine the detailed mechanisms of GA peels, especially with regard to cell proliferation and apoptotic changes through activating signalling cascades and oxidative stress .…”

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

“…4 Serum AChE levels in the control and the different treated groups. Different letters mean statistical significance at P B 0.05 according to oneway ANOVA followed by Tukey's Range Test for post hoc analysis degenerative diseases such as cataract, cancer, stroke, coronary heart disease, diabetes, rheumatoid arthritis, Alzheimer's disease and ageing process (Akash et al , 2013Abdel-Daim et al 2010a, b;Funasaka et al 2012;Willcox et al 2004). Diazinon, an organophosphrus insecticide, has been widely used in industrial, veterinary, and agriculture practice, that would be potentially an exposure risk to animals and human as well (Larkin and Tjeerdema 2000).…”

Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica

“…PGE 2 derived from COX metabolic pathway, is able to promote changes in vascular tonus and blood flow leading to edema as a cardinal sign of inflammation. Cox 2 and PGE 2 are not only inflammatory mediators, but also they act as biomarkers in different cancer cell types (Abdel-Daim et al 2010a, b;Funasaka et al 2012;Elzagheid et al 2013;Karavitis et al 2012;Perez-Ruiz et al 2012). So, it is important to examine the cytotoxic activities of the extract beside its anti-inflammatory activity.…”