Effect of Chia oil (Salvia Hispanica) rich in ω-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma

Espada, Constanza E.; Berra, María Alejandra; Martinez, M J; Eynard, Aldo R.; Pasqualini, Marìa Eugenia

doi:10.1016/j.plefa.2007.05.005

Cited by 39 publications

(29 citation statements)

References 24 publications

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“…Sacha inchi oil (42 to 48% ALA) is obtained from the fruit Plukenetia volubilis, known as Inca Peanut (native from Peru) (Maurer et al, 2012). Chia oil (60 to 65% ALA) is obtained from the seed Salvia hispanica or chia seed (native from Mexico and Guatemala) (Espada et al, 2007). These oils could be considered new and innovative food sources of ALA, which may improve the drastic imbalance in the n-6/n-3 LCPUFA ratio of the western population (Simopoulos, 1999;Simopoulos, 2008).…”

Section: Introductionmentioning

confidence: 99%

Vegetable oils rich in alpha linolenic acid allow a higher accretion of n-3 LCPUFA in the plasma, liver and adipose tissue of the rat

Valenzuela¹,

Barrera²,

Ayala³

et al. 2014

Grasas y Aceites

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SUMMARY:ALA is the precursor of EPA and DHA and its dietary availability is limited. Vegetable oils rich in ALA (48-64%) are alternatives for increasing its consumption. The conversion of ALA into EPA and DHA and the ratio (EPA+DHA/ALA) was evaluated in different tissues from male Wistar rats fed ALA -rich oils. Four groups (n=12/group) were fed for 21 days with oils from: a) corn (CO, 3% ALA); b) soybean (SO, 6% ALA); c) sacha inchi (SIO, 48% ALA) and; d) chia (ChO, 64% ALA). SO, SIO and ChO significantly increased ALA levels (p<0.05) in the tissues. Only SIO and ChO increased tissue EPA and DHA while reducing n-6/n-3 ratio (p<0.05). SIO and ChO are suggested as good sources of ALA to increase tissue EPA and DHA.KEYWORDS: Alpha linolenic acid; Chia oil; Docosahexaenoic acid; Eicosapentaenoic acid; n-3 LCPUFA; Sacha inchi oil RESUMEN: Aceites vegetales ricos en ácido alfa linolénico permiten un mayor almacenamiento de AGPICL n-3 en el plasma, hígado y tejido adiposo de la rata. ALA es precursor de EPA y DHA y sus fuentes dietarias son limitadas. Aceites ricos en ALA (48-64%) son una alternativa para incrementar su consumo. En este trabajo se evaluó la conversión de ALA a EPA y DHA, y la relación (EPA+DHA/ALA) en tejidos de ratas macho Wistar alimentadas con aceites con alto contenido en ALA. Cuatro grupos (n=12/grupo) recibieron durante 21 días aceite de: a) maíz (CO, 3% ALA); b) soja (SO, 6% ALA); c) sacha inchi (SIO, 48% ALA) y; d) chía (ChO, 64% ALA). SO, SIO y ChO incrementaron ALA (p<0,05) en los tejidos. Solo SIO y ChO incrementaron el EPA y DHA, disminuyendo la relación n-6/n-3 (p<0,05). Se propone SIO y ChO como fuentes de ALA para incrementar EPA y DHA en los tejidos. PALABRAS-CLAVE: Aceite de chía; Aceite de sacha inchi; Ácido alfa linolénico; Ácido docosahexaenoico; Ácido eicosapentaenoico; AGPICL n-3Citation/Cómo citar este artículo: Valenzuela R, Barrera C, Ayala JM, Sanhueza J, Valenzuela A. 2014. Vegetable oils rich in alpha linolenic acid allow a higher accretion of n-3 LCPUFA in the plasma, liver and adipose tissue of the rat. Grasas Aceites 65 (2): e026. doi: http://dx

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Section: Introductionmentioning

confidence: 99%

Vegetable oils rich in alpha linolenic acid allow a higher accretion of n-3 LCPUFA in the plasma, liver and adipose tissue of the rat

Valenzuela¹,

Barrera²,

Ayala³

et al. 2014

Grasas y Aceites

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“…In this way, experimental data from our laboratory with murine models of mammary cancer fed with Chia oil (Salvia Hispanica) rich in ω-3 showed that this diet modifies tumor cells, enriching membranes with ω-3 PUFAs with a concomitant decrease in the AA- derivative eicosanoids 12-HETE and 12-HHT—both associated with cancer cell proliferation and lymphocyte migration. Increased apoptosis and infiltration of T-lymphocytes and inhibition of tumor growth and metastasis formation were also observed in association to minor production of these eicosanoids [136]. …”

Section: Introductionmentioning

confidence: 99%

Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors

Comba

Lin

Eynard

et al. 2011

Cancer Metastasis Rev

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This article reviews the current knowledge and experimental research about the mechanisms by which fatty acids and their derivatives control specific gene expression involved during carcinogenesis. Changes in dietary fatty acids, specifically the polyunsaturated fatty acids (PUFAs) of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases (LOXs), cyclooxygenases (COXs), and cytochrome P-450 (CYP-450), seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator–activated receptors (PPARs) or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C [PKC]) and other transcription factors (nuclear factor kappa B [NFκB] and sterol regulatory element binding protein [SREBP]). Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer, and provide insight into the development of new therapeutic strategies for a better management of whole-body lipid metabolism.

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“…19,24 In our current NE design, chia seed oil was employed as the core oil matrix for incorporation of Gen. Chia (Salvia hispanica) is a biannual plant native to South America, mostly cultivated for its seeds, which contain high levels of ω-3 and ω-6 PUFAs, as well as fibers and proteins. 35,36 Notably, the fatty acid component of this oil tends to be mostly ω-3 fatty acids (approximately 60% overall, mostly as α-linolenic acid) and some ω-6 fatty acids (20% in general, mostly as γ-linolenic acid). 37 In addition, some active phenolic compounds are present in chia seed oil, with "myricetin", an antioxidant flavonol, being the most plentiful one.…”

Section: 34mentioning

confidence: 99%

Layered nanoemulsions as mucoadhesive buccal systems for controlled delivery of oral cancer therapeutics

Gavin¹,

Pham²,

Wang³

et al. 2015

IJN

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Oral cavity and oropharyngeal cancers are considered the eighth most common cancer worldwide, with relatively poor prognosis (62% of patients surviving 5 years, after diagnosis). The aim of this study was to develop a proof-of-concept mucoadhesive lozenge/buccal tablet, as a potential platform for direct sustained delivery of therapeutic antimitotic nanomedicines. Our system would serve as an adjuvant therapy for oral cancer patients undergoing full-scale diagnostic and operative treatment plans. We utilized lipid-based nanocarriers, namely nanoemulsions (NEs), containing mixed-polyethoxylated emulsifiers and a tocopheryl moiety–enriched oil phase. Prototype NEs, loaded with the proapoptotic lipophilic drug genistein (Gen), were further processed into buccal tablet formulations. The chitosan polyelectrolyte solution overcoat rendered NE droplets cationic, by acting as a mucoadhesive interfacial NE layer. With approximate size of 110 nm, the positively charged chitosan-layered NE (+25 mV) vs negatively charged chitosan-free/primary aqueous NE (−28 mV) exhibited a controlled-release profile and effective mucoadhesion for liquid oral spray prototypes. When punch-pressed, porous NE-based buccal tablets were physically evaluated for hardness, friability, and swelling in addition to ex vivo tissue mucoadhesion force and retention time measurements. Chitosan-containing NE tablets were found equivalent to primary NE and placebo tablets in compression tests, yet significantly superior in all ex vivo adhesion and in vitro release assays ( P ≤0.05). Following biocompatibility screening of prototype chitosan-layered NEs, substantial anticancer activity of selected cationic Gen-loaded NE formulations, against two oropahryngeal carcinomas, was observed. The data strongly indicate the potential of such nanomucoadhesive systems as maintenance therapy for oral cancer patients awaiting surgical removal, or postresection of identified cancerous lesions.

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Effect of Chia oil (Salvia Hispanica) rich in ω-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma

Cited by 39 publications

References 24 publications

Vegetable oils rich in alpha linolenic acid allow a higher accretion of n-3 LCPUFA in the plasma, liver and adipose tissue of the rat

Vegetable oils rich in alpha linolenic acid allow a higher accretion of n-3 LCPUFA in the plasma, liver and adipose tissue of the rat

Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors

Layered nanoemulsions as mucoadhesive buccal systems for controlled delivery of oral cancer therapeutics

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