Effect of chitosan characteristics and solution conditions on gelation temperatures of chitosan/2-glycerophosphate/nanosilver hydrogels

Tsai, Min-Lang; Chang, Hsiang-Wei; Yu, Hui-Chuan; Lin, Ya-Shen; Tsai, Ying-Die

doi:10.1016/j.carbpol.2011.01.035

Cited by 41 publications

(15 citation statements)

References 28 publications

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“…Co. Ltd. (Taoyuan, Taiwan) and Hua Shang Food Enterprise Co. Ltd. (Taoyuan,Taiwan), respectively. The chitosan (degree of deacetylation: 80%, molecular weight: 900 kDa) was prepared from squid pens as described by Tsai, Chang, Yu, Lin, and Tsai (2011). Potassium bromide, acetic acid, and iron (III) chloride hexa hydrate were purchased from Merck (Darmstadt, Germany).…”

Section: Methodsmentioning

confidence: 99%

Effect of crosslinked condition on characteristics of chitosan/tripolyphosphate/genipin beads and their application in the selective adsorption of phytic acid from soybean whey

Yang

Hsu

Tsai

2011

Carbohydrate Polymers

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Section: Methodsmentioning

confidence: 99%

Effect of crosslinked condition on characteristics of chitosan/tripolyphosphate/genipin beads and their application in the selective adsorption of phytic acid from soybean whey

Yang

Hsu

Tsai

2011

Carbohydrate Polymers

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“…Chitosan consists of b-(1,4)-linked D-glucosamine units with variable degrees of N-acetylation (Casettari et al, 2012). It has been used for tissue regeneration (Ma et al, 2010;Cooper et al, 2011;Park et al, 2013) and drug delivery applications (Rokhade et al, 2007;Abruzzo et al, 2012;Ferrari et al, 2013) because of its tissue compatibility, biodegradability and low toxicity (Ao et al, 2011;Cooper et al, 2011;Tsai et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin

Tahrir¹,

Ganji²,

Mani

et al. 2014

Drug Delivery

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Injectable In situ gel-forming chitosan/b-glycerol phosphate (CS/b-Gp) solution can be introduced into the body in a minimally invasive manner prior to solidifying within the target tissue. This hydrogel is a good candidate for achieving a prolonged drug delivery system for insulin considering its high molecular weight. In addition to the physicochemical characterization of this hydrogel, in vitro and in vivo applications were studied as a sustained insulin delivery system. In the in vitro release studies, 19-63% of total insulin was released from the CS/b-Gp hydrogel within 150 h at different b-Gp and insulin concentrations. The best formulation was selected for in vivo experimentation to control the plasma glucose of diabetic mice models. The hypoglycemic effect of this formulation following subcutaneous injection in diabetic mice lasted 5 d, significantly longer than that of free insulin solution which lasted several hours.

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“…Composite nanomaterials of Cs-GP hydrogel and silver nanoparticles (NPs) with potential applications in medicine due to their antibacterial activity have also been documented [40,41].…”

Section: Applicationsmentioning

confidence: 99%

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.

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Effect of chitosan characteristics and solution conditions on gelation temperatures of chitosan/2-glycerophosphate/nanosilver hydrogels

Cited by 41 publications

References 28 publications

Effect of crosslinked condition on characteristics of chitosan/tripolyphosphate/genipin beads and their application in the selective adsorption of phytic acid from soybean whey

Effect of crosslinked condition on characteristics of chitosan/tripolyphosphate/genipin beads and their application in the selective adsorption of phytic acid from soybean whey

In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin

Chitosan-Based Thermosensitive Materials

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