Effect of Chitosan on the Properties of Electrospun Fibers From Mixed Poly(Vinyl Alcohol)/Chitosan Solutions

Gonçalves, Raquel; Ferreira, Willian H.; Gouvêa, Rodrigo F.; Andrade, Cristina T.

doi:10.1590/1980-5373-mr-2016-0618

Cited by 56 publications

(25 citation statements)

References 38 publications

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“…where σ o is the pre-exponential factor, which is related to the number of charge carriers; E A is the activation energy, which represents the minimum energy required for an ion to jump from one position to another; and K B is the Boltzmann constant. Based on the least squares fit, the linearization of Equation (4) is carried out with Equation (5).…”

Section: Complex Impedance Spectroscopymentioning

confidence: 99%

“…Additionally, polyvinyl alcohol (PVA) is a biodegradable synthetic polymer that presented high ionic conductivities when the polymeric matrix was doped with hypophosphorous acid in studies by González and Vargas [4]. Gonçalves et al [5], Ali and Gherissi [6], Aziz et al [7], Benítez et al [8], and Quintana et al [9] reported that blending of chitosan with synthetic polymers, such as PVA, is a convenient method for preparation of synthetic biodegradable polymers having versatile properties such as good water absorbance and enhance mechanical properties. Additionally, Gonçalves et al [5] found important information on the role of CS on the mechanical properties of the blended films in the composition between 70:30 to 85:15.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Chitosan/PVA/TiO2 Nanocomposite for Application as a Solid Polymeric Electrolyte in Fuel Cells

2020

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The influence of the incorporation of nanoparticles of titanium oxide (TiO2) at a concentration between 1000 and 50,000 ppm on the physicochemical and mechanical properties of a polymer matrix formed from a binary mixture of chitosan (CS) and polyvinyl alcohol (PVA) at a ratio of 80:20 and the possibility of its use as a solid polymeric electrolyte were evaluated. With the mixture of the precursors, a membrane was formed with the solvent evaporation technique (casting). It was found that the incorporation of the nanoparticles affected the moisture absorption of the material; the samples with the highest concentrations displayed predominantly hydrophobic behavior, while the samples with the lowest content displayed absorption values of 90%. Additionally, thermogravimetric analysis (TGA) showed relatively low dehydration in the materials that contained low concentrations of filler; moreover, differential scanning calorimetry (DSC) showed that the nanoparticles did not significantly affect the thermal transitions (Tg and Tm) of the compound. The ionic conductivity of the compound with a relatively low concentration of 1000 ppm TiO2 nanoparticles was determined by complex impedance spectroscopy. The membranes doped with a 4 M KOH solution demonstrated an increase in conductivity of two orders of magnitude, reaching values of 10−6 S·cm−1 at room temperature in previously dried samples, compared to that of the undoped samples, while their activation energy was reduced by 50% with respect to that of the undoped samples. The voltage–current test in a proton exchange membrane fuel cell (PEMFC) indicated an energy efficiency of 17% and an open circuit voltage of 1.0 V for the undoped compound, and these results were comparable to those obtained for the commercial membrane product Nafion® 117 in evaluations performed under conditions of 90% moisture saturation. However, the tests indicated a low current density in the undoped compound.

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Section: Complex Impedance Spectroscopymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a Chitosan/PVA/TiO2 Nanocomposite for Application as a Solid Polymeric Electrolyte in Fuel Cells

2020

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“…In electrospinning method nanofibers are produced by feeding a polymer solution in a high electric field. The high loading capacity, high encapsulation efficiency, delivery of multiple drugs, enhancement of drug solubility and cost‐effectiveness have been the reasons for trends to application of electrospun nanofibers in drug delivery 5,6 …”

Section: Introductionmentioning

confidence: 99%

Electrospinning of polyvinyl alcohol/chitosan/hyaluronic acid nanofiber containing growth hormone and its release investigations

Hosseini

Shahraky

Amani

et al. 2020

Polymers for Advanced Techs

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A wound is defined as an interruption in the integrity of skin and mucus tissue. There are challenges in the treatment of some lesions, such as diabetic ulcers, burn injuries and pressure ulcers. Wound dressing is one of the new methods used to treat these types of ulcers. Nanofibers are very suitable structures for wound healing due to their prevention of pathogen penetration into the wound environment and providing sufficient gaseous exchange, absorption of wound secretions and controlled release of the drug to the site of damage. These nanofibers can carry therapeutic proteins such as the human growth hormone (hGH). Resulting system provides sustained delivery of hGH, thereby achieving sustained therapeutic concentrations of these agents in the blood. Because of the biocompatibility, biodegradability, nonimmunological and nontoxic nature of polyvinyl alcohol, chitosan and hyaluronic acid, they were used to prepare nanofibers via the electrospinning method. In order to evaluate stability of the nanofibers, they were cross‐linked with glutaraldehyde and examined with respect to morphology and size before and after cross‐linking using SEM. Nanofiber characteristics such as hydrophilicity, cytotoxicity, and the manner of release were tested by carrying out water contact angle, MTT and ELISA test. Diameters of the nanofibers were 261 ± 17 and 288 ± 20 nm before and after cross‐linking, respectively, and the results of investigating hydrophilicity at 2 and 5 seconds demonstrated angles of 57.8 and 34.7° respectively, thus indicating that the nanofibers are hydrophilic. The MTT test showed that nanofibers do not have any toxicity towards skin fibroblasts. It was also shown that nanofibers provide a sustained release mechanism after an initial burst release, so that after 2 days, 64% of the growth hormone is released from the nanofibers.

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“…It showed that the specific functional group of every compound was in there, such as amide I stretching, C = O, C-O-C complex from chitosan, hyaluronic acid, and collagen at wavenumber of 1643.53, 1406.64, and 1082.67 cm -1 , respectively. The absorption peak at wavenumber of 3434.41 cm -1 was the hydroxyl functional group from every material and also the result of crosslinking [14,17,18]. There was a slight shift of absorption peak of amide I functional group which indicated the result of crosslinking process.…”

Section: Synthesis Of Collagen-hyaluronic Acid-peo-based Electrospun mentioning

confidence: 89%

Chitosan-Coated Collagen-Hyaluronic Acid-Poly Ethylene Oxide-Based Electrospun Membrane for Corneal Ulcers Wound Dressing Candidate

Putra

Fahmadiyah

Hikmawati

et al. 2020

Walailak J Sci & Tech

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Corneal disease is the 2nd biggest reason of blindness after cataract. Based on WHO data, it was predicted that 10 million people in the world would suffer from cornea-related sight deficiency. One of the solutions is by using wound dressing to cover the cornea so that it could heal effectively. Several studies were conducted to observe the use of collagen, hyaluronic acid, and PEO for wound dressing. To increase the properties of the membrane, chitosan coating was introduced. In this study, we observe the effect of chitosan coating on the electrospun membrane based on collagen, hyaluronic acid, and PEO combined with glutaraldehyde as a crosslinker. The result in FTIR test showed that the crosslinking process ended up in new bond formed among the materials used in this study. The chitosan coating could increase the transparency of the membrane as shown by the result of UV/Vis Spectrophotometry test but the result was not significantly different (p-value > 0.05). The morphology test using SEM showed that the pore diameter of the membrane decreased with the presence of chitosan coating (p-value < 0.05). Likewise, with an increase of chitosan coating concentration, the pores diameter also decreased. The cytotoxicity test showed that the membrane with several chitosan coating concentrations were non-toxic with cell viability more than 50 % (p-value < 0.05). The chitosan coating also had antibacterial effect as shown by the inhibition zone (p-value < 0.05), especially to Pseudomonas aeruginosa as gram positive bacteria. In conclusion, the presence of chitosan coating could improve the characteristics of the electrospun membrane coated with chitosan for wound dressing in corneal ulcers case.

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Effect of Chitosan on the Properties of Electrospun Fibers From Mixed Poly(Vinyl Alcohol)/Chitosan Solutions

Cited by 56 publications

References 38 publications

Development of a Chitosan/PVA/TiO2 Nanocomposite for Application as a Solid Polymeric Electrolyte in Fuel Cells

Development of a Chitosan/PVA/TiO2 Nanocomposite for Application as a Solid Polymeric Electrolyte in Fuel Cells

Electrospinning of polyvinyl alcohol/chitosan/hyaluronic acid nanofiber containing growth hormone and its release investigations

Chitosan-Coated Collagen-Hyaluronic Acid-Poly Ethylene Oxide-Based Electrospun Membrane for Corneal Ulcers Wound Dressing Candidate

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