Effect of Chlorhexidine Application on the Long-term Shear Bond Strength to Dentin of a Resin-modified Glass Ionomer

Dursun, Elisabeth; Goff, Stan; Ruse, N. Dorin; Attal, Jean‐Pierre

doi:10.2341/11-501-l

Cited by 14 publications

(20 citation statements)

References 37 publications

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“…chlorhexidine, carbodiimide, or cross‐linkers of collagen fibrils) improve the durability of resin–dentin bonds in vitro and in vivo . In dentistry, the most popular MMP inhibitor is chlorhexidine because it also possesses antimicrobial activity and has already been used as a pretreatment agent for cavities for dental restorations . Chlorhexidine binds the MMP active site of Zn 2+ and Ca 2+ by cation‐chelation, resulting in the inhibition of catalytic activity of MMPs .…”

Section: Discussionmentioning

confidence: 99%

Inhibition of matrix metalloproteinases and toxicity of gold and platinum nanoparticles in L929 fibroblast cells

Hashimoto

Yamaguchi

Sasaki

et al. 2015

European J Oral Sciences

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This study evaluated the inhibition of matrix metalloproteases (MMPs) and cellular responses elicited by gold (Au) and platinum (Pt) nanoparticles (NPs). The interaction of MMP-1 and NPs was evaluated using an MMP assay kit. The cultured L929 cells were exposed to various concentrations of NPs. The cellular responses to NPs were examined using a cytotoxicity assay (that evaluated cell viability and lactic dehydrogenase production), real-time polymerase chain reaction (RT-qPCR), and transmission electron microscopy. Both types of NPs, when used at concentrations above 10 μg ml(-1), inhibited MMP-1 activity. No cytotoxic effects were found when the cells were exposed to AuNPs. In contrast, PtNPs, at both 100 and 400 μg ml(-1), induced cytotoxicity. No inflammatory responses (production of interleukin-6 and tumor necrosis factor-alpha) to NPs were identified by RT-qPCR. The negative surface charge of NPs (COOH(-)) binds to the Zn(2+) of the MMP active center by chelation, leading to MMP inhibition. Gold nanoparticles are plausible candidates for MMP inhibitors in resin-bonding materials because they effectively inhibit MMP-1 activity without cytotoxic or inflammatory effects.

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Section: Discussionmentioning

confidence: 99%

Inhibition of matrix metalloproteinases and toxicity of gold and platinum nanoparticles in L929 fibroblast cells

Hashimoto

Yamaguchi

Sasaki

et al. 2015

European J Oral Sciences

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show abstract

“…Two separate examiners observed the mode of failure in each specimen under a stereomicroscope (NZ.1902-P; Euromex, Arnhem, Netherlands) at ×20 magnification and failure modes were classified as either adhesive (failure at the dentin/composite interface), cohesive (failure within the resin composite or dentin), or mixed (partial adhesive/partial cohesive fracture). [ 12 13 ]…”

Section: Methodsmentioning

confidence: 99%

Shear bond strength of bulk-fill and nano-restorative materials to dentin

2016

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Objectives:Bulk-fill composite materials are being developed for preparation depths of up to 4 mm in an effort to simplify and improve the placement of direct composite posterior restorations. The aim of our study was to compare shear-bond strength of bulk-fill and conventional posterior composite resins.Materials and Methods:In this study, 60 caries free extracted human molars were used and sectioned parallel to occlusal surface to expose midcoronal dentin. The specimens were randomly divided into four groups. Total-etch dentine bonding system (Adper Scotchbond 1XT, 3M ESPE) was applied to dentin surface in all the groups to reduce variability in results. Then, dentine surfaces covered by following materials. Group I: SonicFill Bulk-Fill, Group II: Tetric EvoCeram (TBF), Group III: Herculite XRV Ultra, and Group IV: TBF Bulk-Fill, 2 mm × 3 mm cylindrical restorations were prepared by using application apparatus. Shear bond testing was measured by using a universal testing machine. Kruskal–Wallis and Mann–Whitney U-tests were performed to evaluate the data.Results:The highest value was observed in Group III (14.42 ± 4.34) and the lowest value was observed in Group IV (11.16 ± 2.76) and there is a statistically significant difference between these groups (P = 0.046). However, there is no statistically significant difference between the values of other groups. In this study, Group III was showed higher strength values.Conclusion:There is a need for future studies about long-term bond strength and clinical success of these adhesive and bulk-fill systems.

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“…[ 3 4 ] This conditioning step removes the smear layer and exposes the collagen fibrils up to approximately 0.5–1 μm in depth. [ 5 ] The pH of this conditioner is about 1.90 (ftp://ftp.endoco.com/MSDS/GCCavityConditioner.pdf). Some collagen fibrils at the base of the hybrid layer may remain unprotected when PAA conditioner is used before RMGI restoration.…”

Section: Introductionmentioning

confidence: 99%

“…[ 13 14 15 ] The effect of chlorhexidine and ethylenediaminetetraacetic acid (EDTA) as an MMP inhibitor on the resistance of RMGIC-dentin bond to degradation has been studied. [ 5 6 ] Chlorhexidine failed to increase the long-term stability of the bond,[ 5 ] but EDTA could avoid a decrease in bond strength after 3 months of storage. [ 6 ] The aim of the present study was to test the following null hypotheses: (1) carbodiimide and PA do not affect the shear bond strength (SBS) of RMGI after 24 h and 6 months and (2) there is no difference between 24-h and 6-month SBS in the study groups.…”

Section: Introductionmentioning

confidence: 99%

The effect of two cross-linking agents on dentin bond strength of resin-modified glass ionomer

2017

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Objectives:The hybrid layer at the interface of resin-modified glass ionomer cements and dentin is prone to degradation by endogenous matrix metalloproteinases. We aimed to investigate the effect of two types of collagen crosslinkers, carbodiimide and proanthocyanidin (PA), on immediate and medium-term bond strength of a resin-modified glass ionomer to dentin.Materials and Methods:Seventy-two molars were flattened on the occlusal surface to expose dentin. The specimens were divided into control, 1-ethyl-3-(3-dimethylaminopropy) carbodiimide hydrochloride (EDC), and PA groups (n = 24). In the EDC and PA groups, carbodiimide and PA solutions were applied for 1 min, respectively. Resin-modified glass ionomer was bonded. Half of the specimens in each group were tested for shear bond strength after 24 h and the other half were tested after 6 months.Statistical Analysis:Data were analyzed with SPSS version 16 (SPSS Inc, Chicago, IL, USA), using two-way ANOVA, and subgroup analysis was performed using one-way ANOVA, Tukey's test, and t-test.Results:Two-way ANOVA showed that treatment and time affected the bond strength. Carbodiimide and PA did not affect the immediate bond strength (P = 0.51). After 6 months, the bond strength of the EDC group was significantly lower than that of the control and PA groups. Bond strength of the control and PA groups increased after 6 months (P ≤ 0.002).Conclusion:PA did not interfere with maturation of RMGIC unlike carbodiimide. Therefore, it can be suggested as an matrix metalloproteinase inhibitor before bonding of resin-modified glass ionomer to dentin.

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Effect of Chlorhexidine Application on the Long-term Shear Bond Strength to Dentin of a Resin-modified Glass Ionomer

Cited by 14 publications

References 37 publications

Inhibition of matrix metalloproteinases and toxicity of gold and platinum nanoparticles in L929 fibroblast cells

Inhibition of matrix metalloproteinases and toxicity of gold and platinum nanoparticles in L929 fibroblast cells

Shear bond strength of bulk-fill and nano-restorative materials to dentin

The effect of two cross-linking agents on dentin bond strength of resin-modified glass ionomer

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