Effect of Chloride ion on Dissolution of Different Salt Forms of Haloperidol, a Model Basic Drug

Li, Shoufeng; Doyle, Pamela; Metz, Stephanie; Royce, Alan E.; Serajuddin, Abu T.M.

doi:10.1002/jps.20440

Cited by 69 publications

(59 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The salt solubility of haloperidol described by Li et al [56,57] raises several interesting points in assay design and data interpretation. Figure 3 illustrates the pH-dependent formation of three crystalline salts of haloperidol: hydrochloride, mesylate, and phosphate.…”

Section: Haloperidolmentioning

confidence: 99%

Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Haloperidolmentioning

confidence: 99%

Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Even though salt formation can improve the dissolution rate of drugs with poor water solubility, it is important to note that the salt does not necessary change their pH solubility profiles. The impact of counterions on pH solubility profiles can be complex, and the negative impact of the counterion in dissolution media cannot be ignored (18).…”

Section: Ph Adjustment and Salt Formationmentioning

confidence: 99%

Drug Delivery Approaches in Addressing Clinical Pharmacology-Related Issues: Opportunities and Challenges

Wen¹,

Jung²,

2015

AAPS J

443

189

View full text Add to dashboard Cite

Abstract. Various drug delivery approaches can be used to maximize therapeutic efficacy and minimize side effects, by impacting absorption, distribution, metabolism, and elimination (ADME) of a drug compound. For those drugs with poor water solubility or low permeability, techniques such as amorphous solid dispersion, liposomes, and complexations have been used to improve their oral bioavailability. Modified release (MR) formulations have been widely used to improve patient compliance, as well as to reduce side effects, especially for those drugs with short half-lives or narrow therapeutic windows. More than ten drugs using sterile long-acting release (LAR) formulations with clear clinical benefit have been successfully marketed. Furthermore, drug delivery systems have been used in delaying drug clearance processes. Additionally, modifying the in vivo drug distribution using targeted delivery systems has significantly improved oncology treatments. All the drug delivery approaches have their advantages and limitations. For both brand and generic drugs, the achievement of consistent quality and therapeutic performance using drug delivery systems can also pose serious challenges in developing a drug for the market, which requires close collaboration among industry, academia, and regulatory agencies. With the advent of personalized medicines, there will be great opportunities and challenges in utilizing drug delivery systems to provide better products and services for patients.

show abstract

“…Serajuddin and co-workers 17,52,53 have all demonstrated the negative impact of the common chloride/ hydrochloride ion (HCl or NaCl) on the solubility and dissolution rates of hydrochloride salts in physiological media. This also has adverse impacts on parenteral drug development as 0.9% saline is a commonly used isotonic diluent that has some advantages over the alternative sugar diluents, for example, glucose, sorbitol, or dextrose.…”

Section: Biopharmaceutical Differencesmentioning

confidence: 99%

The Utility of Sulfonate Salts in Drug Development

Elder

Delaney²,

Teasdale

et al. 2010

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Effect of Chloride ion on Dissolution of Different Salt Forms of Haloperidol, a Model Basic Drug

Cited by 69 publications

References 11 publications

Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality

Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality

Drug Delivery Approaches in Addressing Clinical Pharmacology-Related Issues: Opportunities and Challenges

The Utility of Sulfonate Salts in Drug Development

Contact Info

Product

Resources

About