1985
DOI: 10.1016/0147-6513(85)90048-x
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Effect of chlorophenols on isolated plant mitochondria activities: A QSAR study

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Cited by 31 publications
(10 citation statements)
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“…This decrease may be explained by the sulphydryl residue blockage of the enzyme or by the formation of ROS. In the same way, the disturbance of energetic metabolism observed in this study could be related to the data of Ravanel et al (1985) and Aschmann et al (1989), who affirmed that chlorophenols could deplete ATP levels by uncoupling the oxidative phophorylation. All the effects observed as early as 24 h of incubation were extended until 48 h of incubation, but during the second period of exposure (24-48 h) oxidative stress seems to appear in Hep G2 cells in the continuous presence of 4-MCP.…”
Section: Discussionsupporting
confidence: 64%
“…This decrease may be explained by the sulphydryl residue blockage of the enzyme or by the formation of ROS. In the same way, the disturbance of energetic metabolism observed in this study could be related to the data of Ravanel et al (1985) and Aschmann et al (1989), who affirmed that chlorophenols could deplete ATP levels by uncoupling the oxidative phophorylation. All the effects observed as early as 24 h of incubation were extended until 48 h of incubation, but during the second period of exposure (24-48 h) oxidative stress seems to appear in Hep G2 cells in the continuous presence of 4-MCP.…”
Section: Discussionsupporting
confidence: 64%
“…This observation can be justified by the fact that m-dcps act as alternative electron acceptors and donors between complex I (rotenone sensitive) and complex III (antimycin sensitive) in the mitochondrial electron transport chain (Figure 3A). It is known that all m-dcps are mitochondrial uncouplers [53], [54]. Uncoupling properties seem to be associated with the presence of the phenolic hydroxyl that can dissociate at the membrane and play the part of a protonophore group [55].…”
Section: Resultsmentioning
confidence: 99%
“…The non hydroxylated flavone does not behave as an uncoupler (1 1), in contrast with monohydroxylated flavonoids such as the 7-OH flavone (I17), the uncoupling activity of which is comparable to that of isoscutellarein. This is also the case with chalcones (13) and simple phenols (15).…”
Section: Methodsmentioning
confidence: 99%