Effect of chloroquine and some other antimalarials on the immune mechanism in experimental animals

Bhattacharya, Swapan Kumar; Pillai, C. R.; Mathur, Manas; Sen, P

doi:10.1111/j.2042-7158.1984.tb04366.x

Cited by 11 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunological inflammation was then produced by injection of triple antigen (a vaccine composed of a mixture of Diphtheria toxoid, Tetanus toxoid, and killed organisms of strains of Bordetella pertussis) with alum precipitates in the following proportion: 1 ml of Triple antigen, 4 ml of normal saline (0.9% NaCl), and 1 ml of 10% potash alum (Bhattacharya et al, 1981). The pH of the solution was adjusted to 5.6-6.8 using 10% sodium carbonate solutions.…”

Section: Alum Adjuvant-induced Hind Paw Edema In Pre-sensitized Ratsmentioning

confidence: 99%

Immunostimulant Activity ofn-Butanol Fraction of Root Bark ofOroxylum indicum, vent.

Zaveri

Gohil

Jain

2006

Journal of Immunotoxicology

View full text Add to dashboard Cite

In the present study, the immunomodulatory activity and the mechanism of action of the n-butanol fraction (100 mg/kg body weight, per os, once daily for 22 consecutive days) of the root bark of Oroxylum indicum, vent. (Bignoniaceae) was evaluated in rats using measures of immune responses to sheep red blood cells (SRBC haemagglutinating antibody [HA] titer) and delayed-type hypersensitivity (DTH) reactions. In response to SRBC, treatment with the n-butanol fraction caused a significant rise in circulating HA titers during secondary antibody responses, indicating a potentiation of certain aspects of the humoral response. The treatment also resulted in a significant rise in paw edema formation, indicating increased host DTH response. Additionally, the antioxidant potential of the drug was exhibited by significant reductions in whole blood malondialdehyde (MDA) content along with a rise in the activities/levels of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH). Furthermore, histopathologic analysis of lymphoid tissues showed an increase in cellularity, e.g., T-lymphocytes and sinusoids, in the treatment group. In contrast, dexamethasone treatment caused significant reduction in the HA titer, DTH responses, and antioxidant potential. In a triple antigen-mediated immunological edema model, the extent of edema raised in drug-treated rats was greater compared to that in control rats, thus confirming enhanced DTH reactions in response to the drug treatment. Based on the above findings, the reported immunomodulatory activity of an active fraction of O. indicum might be attributed to its ability to enhance specific immune responses (both humoral and cell-mediated) as well as its antioxidant potential.

show abstract

Section: Alum Adjuvant-induced Hind Paw Edema In Pre-sensitized Ratsmentioning

confidence: 99%

Immunostimulant Activity ofn-Butanol Fraction of Root Bark ofOroxylum indicum, vent.

Zaveri

Gohil

Jain

2006

Journal of Immunotoxicology

View full text Add to dashboard Cite

show abstract

“…Since the effects of CHL appear quite early, it is likely that CHL may affect certain cell populations responsible for maintaining the natural immunity of the body, such as natural killer cells or macrophages; the function of these cells is augmented by IFN, and these cells may be involved in the control of viral infections (1,7). Any perturbation or inhibition of these cells by CHL may lead to the increase of viral multiplication (3,17,18). In fact, various antimalarial drugs (viz., CHL, mefloquine, quinine, pyrimethamine, and sulfadoxine) have been shown to suppress natural killer cell activity in vitro (15,16).…”

Section: Chl Was Obtained From Winthrop Laboratories Newmentioning

confidence: 99%

Chloroquine enhances replication of Semliki Forest virus and encephalomyocarditis virus in mice

Maheshwari

Srikantan

Bhartiya

1991

J Virol

View full text Add to dashboard Cite

Chloroquine (CHL) has been suggested to play an important role in the development of Burkitt's lymphoma by enhancing Epstein-Barr virus expression. Herpes zoster virus incidence is markedly increased following malaria infection in children being treated with CHL. Recently, CHL has also been shown to dramatically increase the transactivation of Tat protein purified from human immunodeficiency virus. These previous studies indirectly suggest that CHL may be involved in the enhancement of virus replication. This study demonstrates for the first time that CHL indeed enhances Semliki Forest virus and encephalomyocarditis virus replication in mice. These results raise the possible connection between the increased spread of AIDS in endemic malaria areas and the wide use of CHL in those areas for the chemotherapy of malaria.

show abstract

“…Our observation that chloroquine can selectively reduce production of a single isotype of antibody in unprimed animals might be important for two reasons. First, it may provide a basis for understanding for some of the varied effects of this agent on antibody production (Greenwood 1984;Taylor et al 1984;Bhattacharya et al 1984;Tsai et al 1986), which might a t least in part reflect the ability of chloroquine to affect only certain antigen-induced IgG subclass antibody responses. Second, it may alert clinicians to the potential risks of administering chloroquine to unvaccinated individuals.…”

Section: Resultsmentioning

confidence: 99%

The preferential effects of chloroquine on the IgM and IgG subclass responses to TI and TD antigens in BALB/cAn mice

Lewis

Slack

1990

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

This study has determined the effects of chloroquine on the IgM and the IgG subclass responses of BALB/cAn mice to both thymus-independent (TI) and thymus-dependent (TD) antigens, and has found that in antigen-unprimed BALB/cAn mice chloroquine adversely affects antibody responses to both TI and TD antigens. However, in antigen-primed mice the immune responses to TD antigens were unaffected by chloroquine. The IgGl subclass response, but not necessarily other IgG subclass or IgM responses to TI and TD antigens, was adversely affected by chloroquine in unprimed mice only. Thus, in unprimed, but not in antigen-primed, BALB/cAn mice, chloroquine preferentially decreased the IgGl subclass responses to both TI and TD antigens.

show abstract

Effect of chloroquine and some other antimalarials on the immune mechanism in experimental animals

Cited by 11 publications

References 7 publications

Immunostimulant Activity ofn-Butanol Fraction of Root Bark ofOroxylum indicum, vent.

Immunostimulant Activity ofn-Butanol Fraction of Root Bark ofOroxylum indicum, vent.

Chloroquine enhances replication of Semliki Forest virus and encephalomyocarditis virus in mice

The preferential effects of chloroquine on the IgM and IgG subclass responses to TI and TD antigens in BALB/cAn mice

Contact Info

Product

Resources

About