Effect of Chloroquine on antioxidant enzymes and oxidative system on (Vigna radiata) plant tissues exposed to water stress

Abstract

The aim of the present study is to examine the effect of (Chloroquine CQ) on the oxidative stress under water stress effect Recently, this compound is used to treat COVID-19, Hydrogen peroxide H2O2 effect and Stimulate the enzymatic system through the exposure of the plant to water stress and interaction with Chloroquine, where the stress stimulate the production of these Oxidative Factors (Hydrogen Peroxide, Malondialdehyde(MDA), Protease increase the production of these oxidative factors increase activity through the effect of Chloroquine, This process was performed in the meristematic tissues of the cells of the permanent Mung bean (Vigna radiata) plants under experimental factors (water stress factor for 10 days with control period of 5 days) (Chloroquine factors and concentrations of 125 and 250 mg.L-1 with control treatment) were designed using a Factorial Randomized Block Design (R.B.C.D) with three replicates and 18 experimental units The experimental unit area was 2 m. The results have shown the following; The water stress period of 10 days led to the production of toxic hydrogen peroxide and increased concentration by stress. The effect of water stress was Stimulate the Production of hydrogen peroxide in Meristematic tissues. The effect of Chloroquine CQ with increased concentrations had a role in inhibiting the production of enzymatic antioxidants (Superoxide dismutase(SOD) and Catalase (CAT). The interaction between water stress and increased Chloroquine CQ concentrations has been instrumental in stimulating the production of oxidative Factors.

Chloroquine and hydroxychloroquine in the environment and aquatic organisms: a review

“…Fish and other seafood sources can be easily contaminated by aminoquinolines due to their bioaccumulative potential, as can be seen by Ali et al (2021) for the nematode community, which may be a route to human exposure to residues, concomitant with the consumption of contaminated water (Kumari and Kumar, 2021). Other concern is water stress caused by aminoquinoline residues present in untreated wastewater or without adequate treatment to remove the drugs, which are commonly used by developing countries in irrigation for crop cultivation (Yasmeen et al, 2014), despite being a practice that poses risks to health and the environment, as seen for Vigna Radiata, which can lead to the production of oxidative factors, impacting productivity (Al-Mentafji, 2021).…”