Effect of Chlorpromazine on Rem Rebound in Normal Volunteers

Abstract

The effect of chlorpromazine on the REM deprivation rebound was studied. Five normal subjects participated in the experiment which consisted of three periods of nine nights each. The first period was without medication, the second with medication and the third again without medication. Four dependent variables — Total Sleep Time, REM latency, REM time and REM percentage — were measured in each period as follows: baseline — three nights, REM deprivation — two nights and recovery — four nights. Analysis of variance (three-way classification) was computed in order to evaluate both the main effects as well as the interaction between medication and sleep conditions. The results showed significant difference over the three conditions of sleep — baseline, REM deprivation and recovery. While there were no significant differences due to medication the replication of the measurements in the same subjects proved to be a slightly significant source of the variance of the scores in all variables except REM latency.

Rebound Phenomena: Results of a 10 Years’ (1970-1980) Literature Review

“…Various Phenothiazines and Thioxanthene Derivatives [133][134][135][136] The rebound effects of chlorpromazine were studied in humans and animals. In humans the effect on REM sleep was studied: There was no significant difference between REM rebound with and without medication after sleep deprivation.…”