Effect of Chlorpyrifos on Hematological and Seral Biochemical Components of Fish Oreochromis mossambicus

Ghayyur, Shehzad; Tabassum, Sadia; Ahmad, Munawar Saleem; Akhtar, Naveed; Khan, Muhammad Fiaz

doi:10.17582/journal.pjz/2019.51.3.1047.1052

Cited by 34 publications

(13 citation statements)

References 16 publications

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“…Glucose is the major source of energy and its higher level in plasma act as a stress indicator in present study significant increase in glucose level observed. Our results was in line with findings of (Khan et al 2018) and (Ghayyur et al 2019). Changes in creatinine level shows kidney dysfunction, in present study level of creatinine increased in fish exposed to agrochemical in comparison to control group which may be due to oxidative damage.…”

Section: Discussionsupporting

confidence: 92%

Biochemical, Endocrine and Genetic Impairments in Response to Agrochemicals Intoxication in Common Carp (Cyprinus carpio)

Sanna¹

2021

IJAB

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Worldwide extensive use of agrochemicals in agricultural production poses potential ecotoxicological effects and disturbs aquatic biota, more specially fish. This study aims to evaluate comparative effects of selected agrochemicals such as profenofos, endosulfan and deltamethrin on biochemical, endocrine and genetic profiles of the common carp (Cyprinus carpio L.). Forty healthy carp (50 ± 7.45g and 15 ± 5.86 cm) were selected randomly and equally divided into four groups; control group labeled as E0 and three treated groups having 4 ppb of profenofos, deltamethrin and endosulfan, labeled as E1, E2, E3 respectively. Fish were exposed to chemicals for 96 h. Obtained results revealed that, significant changes were observed in biochemical parameters of treated groups in comparison with control group (P < 0.05): glucose, creatinine, serum amylase, alkaline phosphate, sodium and phosphorus levels increased significantly, while a significant (P < 0.05) reduction was recorded in serum protein, triglycerides, serum lipase and magnesium levels. Whereas significant increase in TSH and cortisol levels were found, while significant decrease (P < 0.05) in T3, T4 and insulin level were observed in experimental groups as compared to control group. Genetic parameters were also affected under the stressors and showed significant increase (P < 0.05) in micronuclei frequency in erythrocytes of treated fish compared to the control group. Toxicities of the three agrochemicals were: endosulfan > deltamethrin > profenofos. The obtained results provide solid evidence that unobservant use of such agrochemical causes a pernicious effect on nontarget organisms such as fish. © 2021 Friends Science Publishers

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Section: Discussionsupporting

confidence: 92%

Biochemical, Endocrine and Genetic Impairments in Response to Agrochemicals Intoxication in Common Carp (Cyprinus carpio)

Sanna¹

2021

IJAB

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“…On the other hand, clinical and epidemiology studies suggest that human exposure to CPF at a low-dose level can lead to health damage, such as chronic degenerative diseases and cancer . Not only in mammal studies, some ecotoxicological research relates to amphibians and fish and also suggests that CPF can significantly disrupt hematological and seral biochemical component levels of oreochromis mossambicus , alter the brain function by up-regulating the expression of bdnf and c-fos in adult zebrafish , damaged visceral organ histopathology of crab ailchiopsis collastinensis and the antioxidant system in freshwater crab. − …”

Section: Introductionmentioning

confidence: 99%

Chlorpyrifos Induces Metabolic Disruption by Altering Levels of Reproductive Hormones

Ren

et al. 2019

J. Agric. Food Chem.

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Chlorpyrifos (CPF) is a widely used organophosphorus pesticide and detected frequently in fruits, vegetables, as well as in urine and blood in humans. Studies have suggested that CPF can induce metabolic disruption, such as type-2 diabetes mellitus and changed body weight. The main mechanisms are based on oxidative damage, fatty-acid synthesis, and lipid peroxidation. Studies have also shown that CPF can change reproductive hormone (RH) levels. CPF might result in metabolic disorders through altered RH levels. Here, we review the studies showing that CFP causes metabolic disruption. Then, we present the studies showing that CFP changes RH levels. Finally, we discuss a potential pathway of how CPF elicits metabolic disruption.

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“…Other researchers reported similar results when Oreochromis mossambicus exposed to zinc nano particles [45], Schizothorax plagiostomus exposed to Atrazine [46], Schizothorax esocinus exposed to cypermethrin [47], Schizothorax esocinus exposed to Atrazine [48], Oreochromis mossambicus exposed to Chlorpyrifos [49].…”

Section: Discussionmentioning

confidence: 59%

Comparative Effects of Selected Agrochemicals on Biochemical Profile and Histopathology of Grass-Carp (<i>Ctenopharyngodon idella</i>)

Khan¹,

Ahmad²,

Ghayyur³

et al. 2022

Pol. J. Environ. Stud.

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The current study was designed to evaluate the comparative effects of three selected chemicals such as emamectin (insecticide), acetochlor (herbicide) and topsin-M (fungicide) on haematology, biochemical profile and histopathology of grass carp (Ctenopharyngdon idella). A total of forty C. Idella was collected from fish farm Hattian Kamra and transported to the Chemistry lab of Government Post Graduate College Haripur in plastic bags containing dissolve oxygen. After acclimatization for a week they were randomly segregated in four groups (E0, E1, E2 and E3) and treated with 5ppb emamectin, acetochlor and topsin-M respectively. After 96hrs of chemical treatment, blood and tissue samples were collected from both control and treated groups for investigation of biochemical and histopathological alterations. Obtained results exhibited significant alteration in haematological parameters i.e. total white blood cells count, MCV, MCH and number of platelets significantly (p<0.05) increased while Red blood cells count, hemoglobin, PCV and MCHC significantly (p<0.05) decreased in the experimental groups E1, E2 and E3 as compared to control group. Significant (p<0.05) changes were observed in biochemical parameters i.e. increase in serum glucose, bilirubin, albumins, blood urea, uric acid, cholesterol, serum calcium, phosphorous, sodium, potassium, serum lipase, CKP, LDH and CK MB, while significant decrease in creatinine, triglycerides, HDL-cholesterol, serum iron, serum amylase, SGPT, alkalinity and Phosphate was observed. The observed Histopathological changes in gills include epithelial

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Effect of Chlorpyrifos on Hematological and Seral Biochemical Components of Fish Oreochromis mossambicus

Cited by 34 publications

References 16 publications

Biochemical, Endocrine and Genetic Impairments in Response to Agrochemicals Intoxication in Common Carp (Cyprinus carpio)

Biochemical, Endocrine and Genetic Impairments in Response to Agrochemicals Intoxication in Common Carp (Cyprinus carpio)

Chlorpyrifos Induces Metabolic Disruption by Altering Levels of Reproductive Hormones

Comparative Effects of Selected Agrochemicals on Biochemical Profile and Histopathology of Grass-Carp (<i>Ctenopharyngodon idella</i>)

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