Effect of chronic cardiac denervation on renal response to saline infusion

Knox, FG; Bb, Davis; Berliner, Robert W.

doi:10.1152/ajplegacy.1967.213.1.174

Cited by 22 publications

(7 citation statements)

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“…Stretch receptors located in the left atrium have been proposed as volume receptors for the control of sodium excretion (16). However, ablation of the afferent cardiac nerves of the dog does not affect the depression of fractional reabsorption by the proximal tubule resulting from the infusion of saline solution (10).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, after infusions of isotonic sodium chloride solution, which increased plasma volume 61 % + SE 5.8, a decrease in fractional reabsorption of 50.7%o + SE 7.2 was associated with large changes in sodium excretion. INTRODUCTION The studies of DeWardener, Mills, Clapham, and Hayter (1) and Levinsky and Lalone (2) Received for publication 10 January 1968 and in revised form 6 March 1968. dog results in an increase in sodium excretion despite a reduction in glomerular filtration rate. Thus, a depression of sodium reabsorption contributes to the natriuresis after saline administration.…”

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confidence: 99%

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Depression of fractional sodium reabsorption by the proximal tubule of the dog without sodium diuresis

Howards¹,

Davis²,

Knox³

et al. 1968

J. Clin. Invest.

104

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A B S T R A C T The effect of infusions of hyperoncotic solutions on fractional sodium reabsorption by the pro)imal tubule of the dog was studied by the recollection micropuncture method. Tubule fluid to plasma inulin concentration ratios were measured for identified proximal tubule segments before and after infusion of 25%o albumin or dextran solutions. Results were compared with changes in fractional reabsorption during saline diuresis. Plasma volume increased 66% + SE 5.8 after infusion of albumin solution and 94% + SE 8.2 after infusion of dextran solution. Fractional sodium reabosorption by the proximal tubule was depressed after infusion of both of these hyperoncotic solutions. Nevertheless, changes in sodium excretion after infusion of albumin and dextran were small. In contrast, after infusions of isotonic sodium chloride solution, which increased plasma volume 61 % + SE 5.8, a decrease in fractional reabsorption of 50.7%o + SE 7.2 was associated with large changes in sodium excretion.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Depression of fractional sodium reabsorption by the proximal tubule of the dog without sodium diuresis

Howards¹,

Davis²,

Knox³

et al. 1968

J. Clin. Invest.

104

View full text Add to dashboard Cite

show abstract

“…In all of the statistical analyses presented below, the data from each animal were averaged and the single average value used in the calculation of over-all mean, standard deviation (SD), and standard error (SE) for the group (20). Since n is reduced to the number of animals and becomes relatively small, a "pooled" standard deviation was determined whenever two groups of data were tested for significant difference, using the equation:…”

Section: Severalmentioning

confidence: 99%

Effect of acute hypertension on sodium reabsorption by the proximal tubule

Koch¹,

Aynedjian²,

Bank³

1968

J. Clin. Invest.

106

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A B S T R A C T The effect of acute hypertension on sodium reabsorption by the proximal tubule was studied in rats by means of micropuncture methods. Hypertension was induced by bilateral carotid artery ligation and cervical vagotomy. Within a few minutes after blood pressure rose (30-60 mm Hg above control levels), a moderate natriuresis and diuresis began. Proximal sodium reabsorption, measured by two independent methods, was found to be markedly suppressed, both in absolute amount per unit length and per unit of tubular volume (C/7rr2). The ratio between tubular volume and glomerular filtration rate (GFR) (7rr2d/V0) was found to be increased. These observations indicate that the inhibition of proximal sodium reabsorption induced by hypertension cannot be explained by the tubular geometry hypothesis of sodium regulation.Several possible hormonal mechanisms were investigated. Intravenous d-aldosterone did not prevent the suppression of sodium transport due to acute hypertension, nor did chronic oral saline loading to reduce the renal content of renin. Constriction of the suprarenal aorta, with maintenance of a normal renal perfusion pressure, did prevent the inhibition of proximal transport during carotid artery occlusion, thus excluding an extrarenally produced natriuretic hormone as the mechanism.An abstract of this work appeared in Clin. Res. 1967.

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“…One probable component of this mechanism is adepressionof therenin-angiotensin-aldosteronesystem by inhibition of renin release and subsequent decreased sodium reabsorption in the distal nephron [33], An additional component may be operative since decreases in sodium reabsorption by the proximal tubule accompany plasma volume expansion. Although the decreased proximal reabsorption was consistent with the exist ence of a receptor sensitive to changes in vascular volume [21], the possibility remained that albumin infusion depressed proximal reabsorption by a direct effect of parathyroid hormone. This mechanism was explored because it was found that the salt-poor hyperoncotic albumin used in previous studies has the capacity to bind sufficient calcium to provide a stimulus for parathyroid hormone release.…”

Section: Role O F Plasma Protein Concentration In the Regulation O F mentioning

confidence: 78%

Effect of Plasma Protein Concentration on Glomerular and Tubular Function

Knox¹,

Schneider²

1974

Nephron

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The plasma protein concentration is important in the maintenance of plasma volume which, in turn, regulates reabsorption by the renal tubule through the renin-angiotensin aldosterone system and perhaps an additional natriuretic system. In addition, the plasma protein concentration in glomerular capillaries has direct effects on the formation of glomerular filtrate since the oncotic pressure of plasma opposes the hydrostatic pressure for filtration. Similarly, the plasma protein concentration in peritubule capillaries influences the uptake of reabsorbate from the renal tubules. Although there is a large body of evidence indicating a relationship between peritubule protein concentration and sodium reabsorption by the proximal tubule, the mechanisms involved and the importance of peritubule capillary protein concentration in the regulation of proximal sodium reabsorption remain unresolved. Finally, protein plays an important role in the concentrating ability of the kidney.

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Effect of chronic cardiac denervation on renal response to saline infusion

Cited by 22 publications

References 0 publications

Depression of fractional sodium reabsorption by the proximal tubule of the dog without sodium diuresis

Depression of fractional sodium reabsorption by the proximal tubule of the dog without sodium diuresis

Effect of acute hypertension on sodium reabsorption by the proximal tubule

Effect of Plasma Protein Concentration on Glomerular and Tubular Function

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