Effect of chronic sleep deprivation and sleep recovery on hippocampal CA3 neurons, spatial memory and anxiety-like behavior in rats

Suresh, K.; Raavi, Venkateswarlu; Kumar, Harendra; Shankar, Vinutha

doi:10.1016/j.nlm.2021.107559

Cited by 22 publications

(22 citation statements)

References 62 publications

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“…Adult rats exposed to 3 weeks of chronic sleep restriction using a platform technique (18 h/day) develop spatial memory impairments that persist at least 3 weeks after sleep restriction [46]. Consistent with behavioral impairments, apical and basal dendritic arborization of CA1 hippocampal neurons was significantly reduced and remained reduced across the 3 weeks of recovery sleep [46]. In this study, corticosterone levels were unchanged across sleep disruption, supporting the notion that minimal stress was experienced across the exposure.…”

Section: Trends In Neurosciencessupporting

confidence: 72%

“…Several studies have explored longer time frames for recovery of hippocampal neurons and memory function to more fully address the question of lasting injury and/or dysfunction. Adult rats exposed to 3 weeks of chronic sleep restriction using a platform technique (18 h/day) develop spatial memory impairments that persist at least 3 weeks after sleep restriction [46]. Consistent with behavioral impairments, apical and basal dendritic arborization of CA1 hippocampal neurons was significantly reduced and remained reduced across the 3 weeks of recovery sleep [46].…”

Section: Trends In Neurosciencesmentioning

confidence: 89%

“…The morphological changes were observed in parallel with reduced basal and maximal oxygen consumption rates in hippocampal, but not cortical, mitochondria after REM sleep deprivation, supporting regional or neuronal differential susceptibility to mitochondrial dysfunction in response to chronic sleep disruption. In support of mitochondrial dysfunction, a number of groups have shown increased oxidative stress (reduced glutathione, increased oxidized: reduced glutathione, increase malondialdehyde) in hippocampal tissue of rats and mice exposed to total sleep deprivation, REM sleep deprivation, and sleep fragmentation [21,46,[55][56][57][58]. Whole brain also shows similar measures of oxidative stress in response to chronic sleep loss [59].…”

Section: Trends In Neurosciencesmentioning

confidence: 99%

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Neural consequences of chronic sleep disruption

Zamore

Veasey

2022

Trends in Neurosciences

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Section: Trends In Neurosciencessupporting

confidence: 72%

Section: Trends In Neurosciencesmentioning

confidence: 89%

Section: Trends In Neurosciencesmentioning

confidence: 99%

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Neural consequences of chronic sleep disruption

Zamore

Veasey

2022

Trends in Neurosciences

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“…Where we did not get any significance, we re-evaluated taking two independent groups individually, and have applied the Mann-Whitney U test. The statistical model used in the present study is following previous literature 31, 32 . The intact and altered pre-synaptic mitochondrial status in the three groups of rats was analyzed using 2-way ANOVA followed by Bonferroni’s multiple comparison tests.…”

Section: Methodsmentioning

confidence: 99%

Acute sleep deprivation induces synaptic remodeling at the soleus muscle neuromuscular junction in rats

Sharma

Roy

Sengupta

et al. 2022

Preprint

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Sleep is important for cognitive and physical performance. Sleep deprivation not only affects neural functions but also results in muscular fatigue. A good night's sleep reverses these functional derangements caused by sleep deprivation. The role of sleep in brain function has been extensively studied. However, its role in neuromuscular junction or skeletal muscle morphology is sparsely addressed although skeletal muscle atonia and suspended thermoregulation during rapid eye movement sleep possibly provides a conducive environment for the muscle to rest and repair; somewhat similar to slow-wave sleep for synaptic downscaling. In the present study, we have investigated the effect of 24 h sleep deprivation on the neuromuscular junction morphology and neurochemistry using electron microscopy and immunohistochemistry in the rat soleus muscle. Acute sleep deprivation altered synaptic ultra-structure viz. mitochondria, synaptic vesicle, synaptic proteins, basal lamina, and junctional folds needed for neuromuscular transmission. Further acute sleep deprivation showed the depletion of the neurotransmitter acetylcholine and the overactivity of its degrading enzyme acetylcholine esterase at the neuromuscular junction. The impact of sleep deprivation on synaptic homeostasis in the brain has been extensively reported recently. The present evidence from our studies shows new information on the role of sleep on neuromuscular junction homeostasis and its functioning.

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“…In mice, changes in neuroinflammation, microglial activation, and neuronal degeneration in the hippocampus have been observed 3 weeks after 7 days of REM sleep deprivation (Yin et al, 2017). In rats, 3 weeks of recovery sleep is insufficient to completely restore changes in the dendritic arborization of hippocampal CA3 that occur with 3 weeks of chronic sleep deprivation (Konakanchi et al, 2022). Thus, recovery from either acute sleep deprivation or chronic sleep restriction appears to be a lengthier process than previously envisioned.…”

Section: Future Directionsmentioning

confidence: 99%

Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain

Lyons

Vanrobaeys

Abel

2023

Journal of Neurochemistry

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In countries around the world, sleep deprivation represents a widespread problem affecting school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep restriction adversely affect individual health, impairing memory and cognitive performance as well as increasing the risk and progression of numerous diseases. In mammals, the hippocampus and hippocampus‐dependent memory are vulnerable to the effects of acute sleep deprivation. Sleep deprivation induces changes in molecular signaling, gene expression and may cause changes in dendritic structure in neurons. Genome wide studies have shown that acute sleep deprivation alters gene transcription, although the pool of genes affected varies between brain regions. More recently, advances in research have drawn attention to differences in gene regulation between the level of the transcriptome compared with the pool of mRNA associated with ribosomes for protein translation following sleep deprivation. Thus, in addition to transcriptional changes, sleep deprivation also affects downstream processes to alter protein translation. In this review, we focus on the multiple levels through which acute sleep deprivation impacts gene regulation, highlighting potential post‐transcriptional and translational processes that may be affected by sleep deprivation. Understanding the multiple levels of gene regulation impacted by sleep deprivation is essential for future development of therapeutics that may mitigate the effects of sleep loss.

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Effect of chronic sleep deprivation and sleep recovery on hippocampal CA3 neurons, spatial memory and anxiety-like behavior in rats

Cited by 22 publications

References 62 publications

Neural consequences of chronic sleep disruption

Neural consequences of chronic sleep disruption

Acute sleep deprivation induces synaptic remodeling at the soleus muscle neuromuscular junction in rats

Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain

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