Effect of cinnamon essential oil on gut microbiota in the mouse model of dextran sodium sulfate‐induced colitis

Li, Aili; Ni, Wei‐Wei; Zhang, Qimin; Liu, Ying; Zhang, Xin; Wu, Hongyan; Du, Peng; Hou, Juncai; Zhang, Yun

doi:10.1111/1348-0421.12749

Cited by 107 publications

(68 citation statements)

References 38 publications

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“…The results suggest that coconut-HFD could produce an increased risk of CRC by stimulating the growth of Prevotella and Bacteroides , while diets rich in EVO or sunflower oil could have a protective effect. Different research with honey polyphenols, essential oi and different vegetable oils, have shown that they were able to improve oxidative stress resistance and intestinal inflammation by Bacteroidetes reduction [ 48 , 49 ]. We could hypothesise that the effect of EVOO is probably due to the presence of polyphenols that characterise this fat of vegetable origin.…”

Section: Discussionmentioning

confidence: 99%

The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention

et al. 2020

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The present study aims to examine the effects of three different high-fat diet (HFD) on mice gut microbiota in order to analyse whether they create the microenvironmental conditions that either promote or prevent colorectal cancer (CRC). We evaluated colonic mucosa-associated microbiota in CD1 mice fed with HFD, based on 60% kcal from fat-containing coconut, sunflower or extra-virgin olive oil as the only source of fat. The main findings were as follows: (a) All HFD produced a decrease in the richness and diversity of the intestinal microbiota that was independent of mouse weight, (b) HFD switched Lactobacillus to Lactococcus. In general, the results showed that both sunflower- and coconut-HFD generated a pro-inflammatory intestinal microenvironment. In brief, coconut-HFD decreased Akkermansia and increased Staphylococcus, Prevotella and Bacteroides spp. abundance. Sunflower-HFD reduced Akkermansia and Bifidobacterium, while enhancing Sphingomonas and Neisseria spp. abundance. In contrast, EVOO-HFD produced an anti-inflammatory microenvironment characterised by a decreased Enterococcus, Staphylococcus, Neisseria and Pseudomonas spp. abundance. At the same time, it increased the Firmicutes/Bacteroidetes ratio and maintained the Akkermansia population. To conclude, EVOO-HFD produced changes in the gut microbiota that are associated with the prevention of CRC, while coconut and sunflower-HFD caused changes associated with an increased risk of CRC.

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Section: Discussionmentioning

confidence: 99%

The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention

et al. 2020

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“…They induced colitis for 7 days and administered CEO for 15 days during and after colitis induction. The results of the study showed that the administration of CEO lead to the alleviation of DSS‐induced colitis through the reduction of the expression of TLR4 and improvement of intestinal flora imbalance (A. l. Li et al, 2020).…”

Section: Medicinal Products Mediate Tlr4 Signalingmentioning

confidence: 99%

The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition of TLR4/NF‐kappaB pathway

Dejban

Nikravangolsefid

Chamanara

et al. 2020

Phytotherapy Research

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Inflammatory bowel disease (IBD) is a lifelong and recurrent disease of the gastrointestinal tract that afflicts many people in the world. Growing evidence has currently indicated that dysfunction of immune system, particularly toll‐like receptors 4 (TLR4) signaling pathway dysfunction plays a pivotal part in the pathogenesis of IBD. TLR4 signaling is involved both in the pathogenesis and in the efficacy of treatment of IBD. There are some medicinal products and herbal medicines, which their role in the treatment of IBD through modulation of TLR4 signaling has been implicated. The purpose of this review article is to summarize those medicinal products and herbal medicines.

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“…IBD is closely related to intestinal epithelial barrier dysfunction, abnormal immune response and gut microbiota dysbiosis (Harris and Chang, 2018;Li et al, 2019). Intestinal epithelial barrier function mainly depended on tight junctions (TJs) between adjacent intestinal epithelium.…”

Section: Introductionmentioning

confidence: 99%

Algal Oil Rich in n-3 PUFA Alleviates DSS-Induced Colitis via Regulation of Gut Microbiota and Restoration of Intestinal Barrier

Tang

Huang

et al. 2020

Front. Microbiol.

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Algal oil is rich in docosahexaenoic acid (DHA) and has various health benefits against human metabolic disorders and disease. This study aimed to investigate the effects of DHA algal oil on colonic inflammation and intestinal microbiota in dextran sulfate sodium (DSS)-induced colitis mice model. Male C57BL/6 mice was induced colitis by 2.5% DSS and followed by 2 weeks of treatment with algal oil (250 or 500 mg/kg/day). The colonic inflammation was assessed by colon macroscopic damage scores, and the degree of neutrophil infiltration was evaluated by measuring tissue-associated myeloperoxidase (MPO) activity in colonic mucosa. Tight junction proteins in the colonic tissue were measured by real-time PCR and western blot. Moreover, the intestinal microbiota and shot chain fatty acids (SCFAs) were estimated by bioinformatic analysis and GC, respectively. Colonic damage due to DSS treatment was significantly ameliorated by algal oil supplementation. In addition, algal oil significantly inhibited the increases of malondialdehyde (MDA) content, MPO activity, pro-inflammatory cytokines level and tight junction proteins expression in DSS-treated mice. Furthermore, supplementation of algal oil modulated the intestinal microbiota structure in DSS induced colitis mice by increasing the proportion of the unidentified_S24_7 and decreasing the relative abundance of unidentified_Ruminococcaceae, Clostridium and Roseburia. On the analysis of SCFAs, the caecal content of acetic acid, propionic acid, isobutyric acid, buturic, and the total SCFAs showed a significant increase in algal oil-administered mice. Together, these results suggested that algal oil rich in DHA inhibited the progress of DSS-induced colitis in mice by modulating the intestinal microbiota and metabolites and repairing the intestinal barrier, which may be applied in the development of therapeutics for intestinal inflammation.

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Effect of cinnamon essential oil on gut microbiota in the mouse model of dextran sodium sulfate‐induced colitis

Cited by 107 publications

References 38 publications

The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention

The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention

The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition of TLR4/NF‐kappaB pathway

Algal Oil Rich in n-3 PUFA Alleviates DSS-Induced Colitis via Regulation of Gut Microbiota and Restoration of Intestinal Barrier

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