Effect of Circadian Rhythm Disruption and Alcohol on the Oxidative Stress Level in Rat Brain

Abstract

Alcohol abuse is often associated with disrupted circadian rhythms and sleep, and the link seems to be bidirectional. In addition, it has been shown that exposure to constant illumination may increase lipid peroxidation in tissues. In this study, we investigated the effects of circadian rhythm disruption (CRD) and chronic alcohol intake (A) alone and in combination (CRD+A), on the oxidative stress in total rat brain homogenate. Our results demonstrated that lipid peroxidation was increased in the brain samples of all experimental animals compared with the control ones. The oxidative stress levels increased in the order: C<CRD<A<(CRD+A). Furthermore, xanthine oxidase activity changed in the order: C<CRD<A=CRD+A. It was proposed that chronic alcohol intake, if accompanied with CRD, might lead to significantly higher lipid peroxidation in the brain, than if present alone. Our data suggest that ethanol metabolites may be involved in the increase of the brain xanthine oxidase activity in rats with chronic alcohol intake.

Melatonin restores hippocampal neural precursor cell proliferation and prevents cognitive deficits induced by jet lag simulation in adult mice

“…One more way is for example the free radical scavenging ability of melatonin . As jet lag raises the oxidative stress in cells, melatonin might have preserved the functional capacity of the hippocampal pyramidal neurons in our experiment due to its potent role as a protector of cells from oxidative stress.…”

In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking

“…Metabolic reactions produce redox potential that plays an important role in circadian rhythm functioning. Previous studies have suggested that ethanol exposure (both acute and chronic) alters several aspects of the circadian rhythm 36 - 39 .…”

Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin

“…Secondary plant components, such as antioxidants [ 5 ], protect the cells and connective tissue against the development of oxidative stress, which is related to several pathological consequences, e.g., neurological [ 6 ], cardio-vascular [ 7 ], dermatological diseases [ 8 ] or aging [ 9 ]. Oxidative stress is induced by various factors, inter alia, solar radiation, smoking, alcohol consumption, lack of sleep, intensive physical activities and psychological stress [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ], and therefore cannot be avoided in daily life. Oxidative stress is characterized by the generation of large amounts of reactive oxygen species (ROS), whose action is responsible for the development of premature skin aging and photo aging [ 7 , 21 ].…”