Effect of cisapride on gastric emptying in horses following endotoxin treatment

Valk, N.; Doherty, Thomas J; Blackford, James T.; Abraha, Tsghe W.; Frazier, Donita L.

doi:10.1111/j.2042-3306.1998.tb04108.x

Cited by 25 publications

(21 citation statements)

References 29 publications

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“…Values for C max were between 13.1 and 21.6 µg/ml (median, 16.71 µg/ml). The T max ranged from 27.9 to 87.3 minutes (median, 47.7 minutes).…”

Section: Resultsmentioning

confidence: 99%

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Comparison of nuclear scintigraphy and acetaminophen absorption as a means of studying gastric emptying in horses

Lohmann¹,

Roussel²,

Cohen³

et al. 2000

ajvr

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“…Values for C max were between 13.1 and 21.6 µg/ml (median, 16.71 µg/ml). The T max ranged from 27.9 to 87.3 minutes (median, 47.7 minutes).…”

Section: Resultsmentioning

confidence: 99%

“…Acetaminophen absorption has been used to demonstrate that cisapride 16 and yohimbine hydrochloride a can attenuate endotoxin-mediated delay in gastric emptying in the horse. Results of another study indicate that metoclopramide hydrochloride has prokinetic effects and atropine has inhibitory effects on gastric emptying in ponies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of nuclear scintigraphy and acetaminophen absorption as a means of studying gastric emptying in horses

Lohmann¹,

Roussel²,

Cohen³

et al. 2000

ajvr

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“…Several methods are available such as nuclear scintigraphy (Ringger et al . 1996), acetaminophen absorption (Valk et al . 1998) and post consumption [ 13 C]‐octanoic acid blood or breath testing (Wyse et al .…”

Section: Discussionmentioning

confidence: 99%

Primary gastric impaction in horses: A retrospective study of 20 cases (2005-2008)

Vainio¹,

Sykes

Blikslager

2010

Equine Veterinary Education

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Summary Primary gastric impaction is an uncommon condition. Furthermore, the factors associated with gastric impaction and the optimal method of treatment are not clear. The aim of this article is to describe the clinical findings, treatment and outcome of horses with a primary gastric impaction. Medical records of horses that presented with a primary gastric impaction between 2005 and 2008 were reviewed and 20 horses with a primary gastric impaction identified. Diagnosis of a primary gastric impaction was made if the horse had been fasted for a minimum of 16 h, a concretion of ingesta precluded visualisation of the margo plicatus and there was no evidence of concurrent intestinal pathology. Thirteen of 20 (65%) horses were presented on an emergency basis. The most common complaint was inappetence (50%) followed by acute colic (35%) and recurrent colic (35%). On initial examination for colic, all horses had a normal heart rate and 7 of 20 (35%) had decreased gastrointestinal borborygmi. All horses were treated with enteral fluid therapy. The median dose of fluids administered per day was 5 doses (range 1–8 doses) of 2–10 l of isotonic electrolyte solution. The median length of treatment until resolution was 2 days (range 1–5 days). Eighteen of 20 (90%) horses survived to discharge. Primary gastric impaction appears to be a condition with clinical signs of inappetence and mild abdominal discomfort. This is the largest group of horses reported that were treated with enteral fluid therapy for a gastric impaction and it was concluded that enteral fluid therapy was of value in this study.

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“…[9][10][11][12] In other studies, cisapride failed to improve gastrointestinal myoelectrical activity after endotoxin administration; however, prior treatment with cisapride attenuated the delay in gastric emptying caused by endotoxin. 13,14 Cisapride also reportedly does not have an effect on gastric emptying in clinically normal horses. a It has been proposed that 5-hydroxytryptamine (5-HT) receptors have an important role in the regulation of motility of the gastrointestinal tract.…”

mentioning

confidence: 93%

In vitro effects of 5-hydroxytryptamine and cisapride on the circular smooth muscle of the jejunum of horses

Nieto

Snyder

Kollias-Baker

et al. 2000

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Clinical Research Abstracts British Equine Veterinary Association Congress 2015 Foreword and Acknowledgements This supplement is devoted to the publication of abstracts from the 2015 Congress of The British Equine Veterinary Association. The quality of research at the Congress was, as in previous years, high, and the selection process was difficult. Despite the inclusion of a larger number of research communications than in previous years only two-thirds of those submitted could be accepted. This year's Congress committee utilised the selection process initiated last year by Professor Celia Marr in partnership with EVJ. Abstracts were reviewed and objectively graded by two peer reviewers and a member of the Congress Committee before being subjected to a final selection process overseen by the Congress Chair. Thereafter, abstracts had to satisfy the requirements of EVJ for publication in this supplement. Those authors who have had their work accepted should be proud of their achievement. Those who were unsuccessful are doubtless disappointed; however, they have the reassurance that the standard was high and the process was fair. deserve thanks and recognition for a year of hard work. Particular thanks also to all of the anonymous peer reviewers who receive no recognition but gave their time not only to grade the abstracts submitted but also to provide constructive feedback to their authors. The selection process adopted for BEVA Congress sets a standard for other meetings to follow. Given the increasing competition for acceptance of research communications at major international meetings, and the importance of achieving acceptance for those seeking to fulfil the requirements of specialist colleges, such a rigourous selection process seems only right. Reasons for performing study: There are limited data surrounding the efficacy of oviductal flushing in restoring fertility in mares with repeated returns to oestrus. Objectives: To determine the conception and foaling rates in mares treated by laparoscopic topical application of prostaglandin E2 (PGE2) to the oviduct(s) in mares: i) in the breeding season (January-May), pre-covering; ii) in the breeding season, post covering; and iii) out of the breeding season (June-December). Study design: Follow-up study. Methods: Analysis of electronic patient records (EPRs) identified 29 mares that underwent oviductal flushing via laparoscopic surgery between 1 January 2008 and 12 October 2014. One mare underwent the procedure twice; once in the breeding season (pre-covering) and once out of the breeding season. Follow-up data were collected via EPRs and from Weatherbys (www.bloodstockreports.co.uk). Results: The procedure was used in 27 Thoroughbreds, one Warmblood and one Hanoverian. Mean age at the time of the procedure was 13.1 years (range 6-22 years). Mean duration barren prior to the procedure was 1.9 years (range 49 days-5.6 years). The mean time post flushing to the first positive ultrasound scan was 31 days, with average time post flushing to foaling of 367.6 days. Of ...

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Effect of cisapride on gastric emptying in horses following endotoxin treatment

Cited by 25 publications

References 29 publications

Comparison of nuclear scintigraphy and acetaminophen absorption as a means of studying gastric emptying in horses

Comparison of nuclear scintigraphy and acetaminophen absorption as a means of studying gastric emptying in horses

Primary gastric impaction in horses: A retrospective study of 20 cases (2005-2008)

In vitro effects of 5-hydroxytryptamine and cisapride on the circular smooth muscle of the jejunum of horses

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