Effect of Cisplatin on Parotid Gland Function in Concomitant Radiochemotherapy

Hey, Jeremias; Setz, J; Gerlach, Reinhard; Vordermark, Dirk; Gernhardt, Christian Ralf; Kuhnt, Thomas

doi:10.1016/j.ijrobp.2008.12.071

Cited by 33 publications

(26 citation statements)

References 27 publications

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“…1 Both radiotherapy and chemotherapeutic agents may lead to morphologic damage in salivary gland tissue. 15,17 Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat head and neck malignancies. Despite its potent antitumour effects, cisplatin is known to cause serious side effects.…”

Section: Discussionmentioning

confidence: 99%

“…2 Hey et al reported that prospective non-randomized study the influence of concomitant radio-chemotherapy with cisplatin tends to cause a higher probability of complication compared to radiotherapy alone. 15 Yamamoto et al reported that, according to their in vitro experimental study, one can assume that cisplatin has enough potential to considerably damage the salivary gland tissue. 16 In the present study, we examined changes in rat submandibular glands after cisplatin infusion, and in the cisplatin group we detected the presence of intense substitution of the parenchyma by fibrous tissue was detected.…”

Section: Discussionmentioning

confidence: 99%

“…The latter especially prevents the regeneration of glandular tissue when progenitor cells are damaged. 15 Another study, by Özel et al, determined that the first sign of the effect of 5-FU on acinar cells in the submandibular gland was changes in cytoplasmic secretory granules, according to histopathological examination with a light microscope. The damage caused by these cytoplasmic secretory granules should be considered among the mechanisms that lead to cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

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The effects of astaxanthin on salivary gland damage caused by cisplatin in the rat

et al. 2017

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Background: Cisplatin is a potent antineoplastic agent widely used for a variety of malignancies. However, it has many dose-limiting side effects such as neurotoxicity, cytotoxicity and ototoxicity. The aim of our study was to determine the effectiveness of astaxanthin (ASX) as a cytoprotective agent against cisplatin-induced cytotoxicity in the submandibular glands of rats.Methods: Thirty-six adult male Wistar albino rats were divided into six groups as follows: group I: saline control; group II: 75 mg/kg/day ASX; group III: 16 mg/kg cisplatin; group IV: 25 mg/kg/day ASX + cisplatin; group V: 75 mg/kg/day ASX + cisplatin; group VI: olive oil + cisplatin. In all groups, submandibular gland histopathological and histochemical investigations were done using a light microscope. Every rat section was semi-quantitatively scored. Neutrophil infiltration density, myoepithelial cell density in the degeneration area, degenerative granular duct cell density, degenerative seromucous acinus cell density, and changes in the content of the secretory granules of seromucous acini and granular ducts of the parenchyma and stroma were calculated.Results: The results of the analysis of the mean acinus area of the submandibular gland revealed that there was a significant decrease in cisplatin group rats when compared to control rats (p<0.05, p=0.00). However, there was no significant difference between-group IV, V and control group in terms of mean acinus area. (p=0.541, p=0.773). The results of the analysis of the mean ducts area of the submandibular gland also showed that there were significant increased group III compared to control rats (p<0.05, p=0.031). There was no significant difference between-group IV, V and control group in terms of mean ducts area (p>0.05, p=0.921). Similarities were observed in the mean ducts area with the group IV and the group V (p>0.05, p=0.571).Conclusions: These results suggest the possibility that the clinical use of ASX could reduce or prevent damage to the salivary gland of patients receiving cisplatin chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effects of astaxanthin on salivary gland damage caused by cisplatin in the rat

et al. 2017

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“…48 Salivary flow is reduced in adults by chemotherapeutic agents cyclophosphamide, cisplatin, bleomycin, methotrexate, doxorubicin, and vinblastine. [49][50][51][52] However, chemotherapy appears to cause less acute damage alone than in combination with cranial irradiation or total body irradiation. 16,53,54 It has also been suggested that the administration of anticholinergic anti-emetics during early phases of chemotherapy may also reduce salivary flow.…”

Section: Discussionmentioning

confidence: 99%

Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy

Hsieh

Hibbert

Shaw

et al. 2010

Cancer

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BACKGROUND:The aim of this study was to examine the effect of antineoplastic therapy on dental development and saliva function in recipients of childhood antineoplastic therapy. METHODS: Patients attending the long-term follow-up clinic at Children's Hospital at Westmead, NSW, Australia, were included if they had received treatment prior to 16 years of age and were in remission for more than 5 years. A dental examination and saliva test were performed for each participant. Holtta's Defect Index (HDI) was used to assess tooth aplasia, microdontia, and root-crown ratio on an orthopantomogram (OPG). Multivariable-adjusted regression analyses were used to estimate the association of patient characteristics and treatment modalities with dental outcomes. RESULTS: One hundred six participants (61% male) were recruited (response rate ¼ 88%). The mean HDI score was 24.7 AE 17.8. A cumulative dose of cyclophosphamide >7500 mg/m 2 increased the HDI score by 13.06 (P ¼ .01). Recipients of cyclophosphamide also had significantly increased odds of exhibiting very low saliva flow (<0.7 mL/min) (odds ratio ¼ 12.43; 95% confidence interval, 2.08-74.35; P ¼ .006). CONCLUSIONS: Children and adolescents who received high doses of cyclophosphamide were at increased risk of dental disturbances. Cyclophosphamide recipients were also at greater risk of exhibiting very low saliva flow. This study applied the HDI to patients receiving all forms of antineoplastic treatment and highlights the dose-dependent relation between cumulative dose of cyclophosphamide and dental disturbances.

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“…Patients were part of a prospective long-term clinical study granted by the German Cancer Aid association (grant no. 106386 and 108429) investigating therapy-related side effects of modern irradiation techniques in head and neck cancer patients [15,17]. The criterion for inclusion was a diagnosis of a primary tumor in the nasopharynx, oropharynx, uvula, tongue base, oral cavity, cheek/parotid gland, or larynx/ hypopharynx.…”

Section: Methodsmentioning

confidence: 99%

The impact of oral rehabilitation on oral health-related quality of life in patients receiving radiotherapy for the treatment of head and neck cancer

et al. 2016

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Effect of Cisplatin on Parotid Gland Function in Concomitant Radiochemotherapy

Cited by 33 publications

References 27 publications

The effects of astaxanthin on salivary gland damage caused by cisplatin in the rat

The effects of astaxanthin on salivary gland damage caused by cisplatin in the rat

Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy

The impact of oral rehabilitation on oral health-related quality of life in patients receiving radiotherapy for the treatment of head and neck cancer

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