Objective. To explore the application effect of cluster-based care in patients with hypertensive disorders of pregnancy and osteoarthritis. Methods. The clinical data of 60 patients with hypertensive disorders of pregnancy and osteoarthritis in our hospital were retrospectively analyzed, among which those receiving routine care from January 2020 to December 2020 were grouped into the control group (30 patients), and those receiving cluster-based care from January 2021 to January 2022 were grouped into the research group (30 patients). Psychological status, care satisfaction, and pregnancy outcomes were compared between the two groups. Results. After intervention, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores in the research group were lower than those in the control group (
P
<
0.05
). There was no statistical significance in the difference of the modes of delivery between the two groups (
χ
2
=
1.763
,
P
>
0.05
). Patients in the research group had a lower incidence of perinatal complications than those in the control group (
χ
2
=
5.689
,
P
<
0.05
). And the satisfaction rate of care in the research group (93.33% vs 70%) was higher than that in the control group (
χ
2
=
4.238
,
P
<
0.05
). Conclusion. Cluster-based care can reduce patients’ negative mood, increase their satisfaction, and improve the maternal and infant outcomes. This type of care offers better quality care measures for patients with pregnancy hypertension and osteoarthritis, and has a wide clinical application prospect.