Effect of Co-administration of Allium sativum extract and Metformin on Blood glucose of Streptozotocin induced diabetic rats

Tripathi, Poonam; Gupta, P. P.; Lal, Vijay

doi:10.5455/jice.20130530123748

Cited by 16 publications

(12 citation statements)

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“…The study by Poonam Tripathi, et al supported present study that Metformin cause weight loss. 17 In the present study, an increase in the levels of blood glucose and HbA1c in STZ-ISP treated rats confirmed the induction of diabetes mellitus. The level of HbA1c is monitored as a reliable index of long term glycemic control in diabetes.…”

Section: Discussionsupporting

confidence: 53%

Myocardial salvaging effects and mechanisms of metformin in experimental diabetes

Borde

Mohanty

Maheshwari

et al. 2016

Int J Basic Clin Pharmacol

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Section: Discussionsupporting

confidence: 53%

Myocardial salvaging effects and mechanisms of metformin in experimental diabetes

Borde

Mohanty

Maheshwari

et al. 2016

Int J Basic Clin Pharmacol

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“…In another study combination therapy of garlic extract (50 or 100 mg/kg) and metformin over 28 days was tested in a rat model of streptozocin-induced diabetes. Garlic alone, as well as in combination with metformin, improved body weight, whilst the combination therapy was more effective in reducing blood glucose levels, highlighting that garlic extract potentiates the hypoglycaemic effect of metformin [67]. Potential beneficial effects of garlic juice in combination with metformin have been shown, where the combination attenuated tubular toxicity induced by gentamicin [68, 69].…”

Section: Common Herb–drug Interactions In Diabetesmentioning

confidence: 99%

Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications

Gupta

Chang

Nammi

et al. 2017

Diabetol Metab Syndr

169

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Diabetes is a complex condition with a variety of causes and pathophysiologies. The current single target approach has not provided ideal clinical outcomes for the treatment of the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with antidiabetic properties in addition to their mainstream treatments, which may present both a benefit as well as potential risk to effective management of their disease. In this review we evaluate the clinical and experimental literature on herb–drug interactions in the treatment of diabetes. Pharmacokinetic and pharmacodynamic interactions between drugs and herbs are discussed, and some commonly used herbs which can interact with antidiabetic drugs summarised. Herb–drug interactions can be a double-edged sword presenting both risks (adverse drug events) and benefits (through enhancement). There is a general lack of data on herb–drug interactions. As such, more rigorous scientific research is urgently needed to guide clinical practice as well as to safeguard the wellbeing of diabetes patients.

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“…However, allicin has proven antimicrobial activity and also active against protozoan parasites including Plasmodium , where it is thought to be mediated by inhibiting cysteine proteases [37] . There are several reports of combination of garlic extracts with antibiotics [38] and also known for its antituberculor activity [39] . Protection of P. berghei -infected mice from early death by allicin through immunomodulation has also been documented [32] , [40] .…”

Section: Resultsmentioning

confidence: 99%

Assessment of in vivo antimalarial activity of arteether and garlic oil combination therapy

Govindan

Panduranga

Murthy

2016

Biochemistry and Biophysics Reports

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The study evaluates in vivo antimalarial activity of arteether and garlic pearl oil combination in Plasmodium berghei-infected mouse model of malaria. 72 h (Day 3) post infection, at 2–4% parasitemia, mice were treated with single dose intramuscular injection of α-β arteether, at 750 μg, in combination with three 100 μL oral doses of garlic pearl oil on Day 3, Day 4 and Day 5. Following the treatment, 100% protection and survival of mice were observed. Inhibition of parasitemia in combination treated animals and protection during recrudescence interval of α-β arteether monotherapy was observed in Giemsa-stained blood smears. In addition, a striking increase in anti-parasite antibody IgG contributing protective immunity during the recrudescence phase was observed. These results correlate with western blot analysis, where sera from the recrudescence stage and later period of arteether and garlic oil combination treated animals found to interact with several parasite specific proteins as compared to controls. The present approach shows that arteether and garlic pearl oil combination provides complete protection in P. berghei-infected mice. Thus, for the first time, garlic pearl oil appears to be an ideal antimalarial candidate in artemisinin combination therapy.

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Effect of Co-administration of Allium sativum extract and Metformin on Blood glucose of Streptozotocin induced diabetic rats

Cited by 16 publications

References 0 publications

Myocardial salvaging effects and mechanisms of metformin in experimental diabetes

Myocardial salvaging effects and mechanisms of metformin in experimental diabetes

Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications

Assessment of in vivo antimalarial activity of arteether and garlic oil combination therapy

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