Effect of co-administration of probiotics with guar gum, pectin and eudragit S100 based colon targeted mini tablets containing 5-Fluorouracil for site specific release

Kumar, Ankit; Gulati, Monica; Singh, Sachin Kumar; Kuppusamy, Gowthamarajan; Prashar, Rahul; Mankotia, Diksha; Gupta, Jay Prakash; Banerjee, Mayukh; Sinha, Shubham Kumar; Awasthi, Ankit; Corrie, Leander; Kumar, Rajan; Patni, Pooja; Kumar, Bimlesh; Pandey, Narendra Kumar; Sadotra, Manik; Kumar, Pardeep; Wadhwa, Sheetu; Khursheed, Rubiya

doi:10.1016/j.jddst.2020.102004

Cited by 27 publications

(10 citation statements)

References 31 publications

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“…The coated tablets are primarily dried using a heat blower and secondarily with a tray drier at 50°C. [14] The core tablet gained 5 ± 2% weight after coating with eudragit S100 as an inner layer. After complete drying, the outer layer by eudragit L100 with weight gain of 5 ± 2% is done.…”

Section: Coating Methodologymentioning

confidence: 99%

Untitled

2021

IJGP

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Aim:The present study aimed to develop and demonstrate the study of combined effects of biodegradable polymer coated with different pH-sensitive polymers in the formulation of Metronidazole tablets for colon targeted drug delivery. Materials and Methods: Metronidazole Hydrochloride is cored with various proportions of biodegradable polymers such as xanthan gum and chitosan. Then, the double-layered system was designed based on pH-sensitive eudragit S100 and eudragit L100 as an inner layer and outer layer, respectively. To evaluate the in-vitro dissolution profile of CODES TM tablets in gastrointestinal fluids, the test was performed using three consecutive media and drug release kinetics are performed. The drug excipient interaction of CODES TM formulation was characterized by Fourier transform infrared (FT-IR). Results and Discussion: From the in-vitro drug release studies, F6 tablets were considered as the optimized formulation, which retard the drug release in the stomach (pH 1.2) and small intestine (pH 7.4) and progressively increase the release of 75.75% in the colon (pH 6.8) due to mucoadhesive properties of chitosan. The FT-IR analysis shows that there is no interaction between drug and excipient. The drug release kinetics followed supercase -II transport with erosion mechanism. Conclusion: Briefly to conclude that CODES TM technology is a promising method for approach to deliver drug to colon due to the controlled release of biodegradable polysaccharides and gastric resistance polymer.

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Section: Coating Methodologymentioning

confidence: 99%

Untitled

2021

IJGP

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“…151,152 One option to modify chelating groups is to attach a hydrophobic group like phosphatidylethanolamine or stearic acid and then fix them onto the liposomal surface either during or after liposome preparation. 153,154 Alternatively, polychelating amphiphilic polymers can increase metal contrast agents (like Gd) loaded onto liposomes. 155 Attaching multiple chelating groups to the main chain of specific polymers makes it possible to load them with several metal atoms.…”

Section: Therapeuticsmentioning

confidence: 99%

Engineered Liposomes in Interventional Theranostics of Solid Tumors

Kommineni

Chaudhari

Conde

et al. 2023

ACS Biomater. Sci. Eng.

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Engineered liposomal nanoparticles have unique characteristics as cargo carriers in cancer care and therapeutics. Liposomal theranostics have shown significant progress in preclinical and clinical cancer models in the past few years. Liposomal hybrid systems have not only been approved by the FDA but have also reached the market level. Nanosized liposomes are clinically proven systems for delivering multiple therapeutic as well as imaging agents to the target sites in (i) cancer theranostics of solid tumors, (ii) image-guided therapeutics, and (iii) combination therapeutic applications. The choice of diagnostics and therapeutics can intervene in the theranostics property of the engineered system. However, integrating imaging and therapeutics probes within lipid self-assembly “liposome” may compromise their overall theranostics performance. On the other hand, liposomal systems suffer from their fragile nature, site-selective tumor targeting, specific biodistribution and premature leakage of loaded cargo molecules before reaching the target site. Various engineering approaches, viz., grafting, conjugation, encapsulations, etc., have been investigated to overcome the aforementioned issues. It has been studied that surface-engineered liposomes demonstrate better tumor selectivity and improved therapeutic activity and retention in cells/or solid tumors. It should be noted that several other parameters like reproducibility, stability, smooth circulation, toxicity of vital organs, patient compliance, etc. must be addressed before using liposomal theranostics agents in solid tumors or clinical models. Herein, we have reviewed the importance and challenges of liposomal medicines in targeted cancer theranostics with their preclinical and clinical progress and a translational overview.

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“…Oral drug-delivery systems based on probiotics gathered interest for colon cancer immunotherapy due to their tumor colonization and targeting characteristics. [171,203,204] The use of dormant bacterial spores can help overcome the physiological limitations of using live bacteria as oral drug delivery vectors. [139,205] Bacterial spores are capable of withstanding extreme acidic environments, poisonous chemicals, and high heat.…”

Section: Bacterial Spores-based Hitchhiking System For Efficient Canc...mentioning

confidence: 99%

“…Oral drug‐delivery systems based on probiotics gathered interest for colon cancer immunotherapy due to their tumor colonization and targeting characteristics. [ 171,203,204 ]…”

Section: Advantages Of Bacteria‐driven Tumor Targeting For Delivery O...mentioning

confidence: 99%

The Role of Hitchhiking in Cancer Therapeutics—A Review

Padmakumar

Koyande

Rengan

2022

Advanced Therapeutics

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Hitchhiking is a phenomenon of cruising on surfaces. Inspired by this process, biomimetic delivery systems leveraging the intrinsic ability of circulatory cells to target tumors exhibit considerable potential in cancer theranostics. Besides human circulatory cell‐mediated hitchhiking, bacteria‐driven hitchhiking strategies also manifest promise in cancer therapy. Such tactics are primarily built using nonpathogenic invasive bacteria with tumor homing capabilities. The chemotherapeutic cargos are hitchhiked onto the circulatory cells or bacterial spores for tumor‐targeted delivery. By integrating the benefits of such cells and therapeutic cargo, numerous efficient delivery systems that implement the notion of hitchhiking for cancer therapy are generated. Following an overview of several hitchhiking concepts, this article reviews various cellular and bacterial hitchhiking approaches for cancer treatment. Additionally, the challenges and prospects in the field of cancer theranostics related to hitchhiking are also discussed.

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Effect of co-administration of probiotics with guar gum, pectin and eudragit S100 based colon targeted mini tablets containing 5-Fluorouracil for site specific release

Cited by 27 publications

References 31 publications

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Engineered Liposomes in Interventional Theranostics of Solid Tumors

The Role of Hitchhiking in Cancer Therapeutics—A Review

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