Effect of Cocaine on Left Ventricular Function

Mehta, Padmaja; Grainger, Terry A.; Lust, Robert M.; Movahed, Assad; Terry, J D; Gilliland, M. G. F.; Jolly, Stanley R.

doi:10.1161/01.cir.91.12.3002

Cited by 19 publications

(7 citation statements)

References 22 publications

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“…14 In addition, cocaine administration can reduce left ventricular function and increase end-systolic wall stress. 15 By increasing heart rate, blood pressure, and contractility, cocaine leads to increased myocardial demand.…”

Section: Pathophysiologymentioning

confidence: 99%

Management of Cocaine-Associated Chest Pain and Myocardial Infarction

McCord¹,

Jneid²,

Hollander³

et al. 2008

Circulation

369

131

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Section: Pathophysiologymentioning

confidence: 99%

Management of Cocaine-Associated Chest Pain and Myocardial Infarction

McCord¹,

Jneid²,

Hollander³

et al. 2008

Circulation

369

131

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“…Animal studies suggest that the increased wall stress seen in acute cocaine intoxication plays an important role in the acute depression of left ventricular function. Following cocaine infusion, ejection-phase indices of left ventricular function are reduced but the effects are attributable to increased wall stress not to reduced contractility (Mehta et al 1995). Pathologic studies showed similarities between cocaine cardiomyopathy and chronic catecholamine stimulation (Tazelaar et al 1987).…”

Section: Cocainementioning

confidence: 99%

Drug-Induced Cardiomyopathies

Klimas¹

2012

Cardiomyopathies - From Basic Research to Clinical Management

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“…As these responses are not associated with a positive ionotropic effect, myocardial wall tension is increased. 35 In addition, there is evidence of direct cocaine-induced toxicity to the myocardium caused by increased oxidative stress. Interestingly, in laboratory conditions the induced myocardial dysfunction may be prevented by the use of antioxidants (vitamin C).…”

Section: Mechanisms Of Cardiovascular Toxicitymentioning

confidence: 99%

Stimulating Stuff: The Pathological Effects of Cocaine and Amphetamines on the Cardiovascular System

Macmahon

Tallentire

2010

Diabetes & Vascular Disease

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P hysicians involved in acute medical take or emergency department work will be well aware of the various acute presentations associated with cocaine and amphetamine use. As the population ages and the heavy users from previous decades accumulate 'crack years', the longer term consequences of these drugs on the cardiovascular system are becoming more evident. This article will review the pharmacology of stimulant drugs and discuss acute and chronic problems associated with their use. Management strategies of acute presentations, including the role of vasodilators in cocaineinduced myocardial infarction, the avoidance of beta-blockers in acute toxicity and the potential role of alpha-2 agonists are discussed. The management of chronic cardiac damage associated with cocaine or amphetamine abuse has an insufficient evidence base to suggest anything other than complete abstinence in combination with well established therapies.

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Effect of Cocaine on Left Ventricular Function

Abstract: Ejection-phase indexes of LV function were reduced by cocaine in this model of conscious, sedated dogs, but effects were attributable to increased wall stress rather than to reduced myocardial contractility. These effects persisted for at least 2 hours after the infusion was stopped.

Cited by 19 publications

References 22 publications

Management of Cocaine-Associated Chest Pain and Myocardial Infarction

Management of Cocaine-Associated Chest Pain and Myocardial Infarction

Drug-Induced Cardiomyopathies

Stimulating Stuff: The Pathological Effects of Cocaine and Amphetamines on the Cardiovascular System

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