Effect of Coenzyme Q₁₀Supplementation in Statin-Treated Obese Rats

Abstract

Statins, HMG-CoA reductase inhibitors, are known to cause serious muscle injuries (e.g. myopathy, myositis and rhabdomyolysis), and these adverse effects can be rescued by co-administration of coenzyme Q10 (CoQ10) with statins. The goal of the current research is to assess the efficacy of combined treatment of CoQ10 with Atorvastatin for hyperlipidemia induced by high-fat diet in SD rats. 4-week-old Sprague-Dawley male rats were fed normal diet or high-fat diet for 6 weeks. Then, rats were treated with either Statin or Statin with various dosages of CoQ10 (30, 90 or 270 mg/kg/day, p.o.) for another 6 weeks. Compared to Statin only-treatment, CoQ10 supplementation significantly reduced creatine kinase and aspartate aminotransferase levels in serum which are markers for myopathy. Moreover, CoQ10 supplementation with Statin further reduced total fat, triglycerides, total cholesterol, and low-density lipoprotein-cholesterol. In contrast, the levels of high-density lipoprotein-cholesterol and CoQ10 were increased in the CoQ10 co-treated group. These results indicate that CoQ10 treatment not only reduces the side effects of Statin, but also has an anti-obesity effect. Therefore an intake of supplementary CoQ10 is helpful for solving problem of obese metabolism, so the multiple prescription of CoQ10 makes us think a possibility that can be solved in being contiguous to the obesity problem, a sort of disease of the obese metabolism.

Assessment of bee venom therapy in animal model of statin-induced myopathy

“…Regarding CK, the present study reports that simvastatin induces CK elevation for more than 4 folds. These findings are in agreement with several other reports both in humans and animals [25][26][27][28]. Co-administration of the bee venom with simvastatin is found to partially reduce CK elevation to 2 folds only, which was still significantly high.…”

Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China

“…Furthermore, myalgia is found to be the most common adverse event of statin use according to the review of MEDLINE database English articles 80 . While the mechanism by which statins produce muscle injuries is still unclear, reduction of the cholesterol content of skeletal muscle membrane is considered as a possible mechanism 81 , 82 . The other possible mechanisms include mitochondrial mechanisms 83 and inhibition of farnesyl pyrophosphate (an intermediate for the production of ubiquinone (Coenzyme Q10)) 81 .…”

Statin-induced rhabdomyolysis in patient with renal failure and underlying undiagnosed hypothyroidism

“…[ 8 ] CoQ 10 supplementation is tried in experimental studies and found to be successful in significantly reducing CK and aspartate aminotransferase levels in serum. [ 9 ] There has also been interest in the use of CoQ 10 , Chinese red rice yeast, and Vitamin D as prevention and/or management of statin-associated myopathy although there is no definite evidence.…”