Effect of coenzyme Q10 on cutaneous healing in skin-incised mice

Choi, Bang Shil; Song, Ho Sun; Kim, Hee Rae; Park, Tae Wook; Kim, Tae Doo; Cho, Bong Jae; Kim, Chang Jong; Sim, Sang Soo

doi:10.1007/s12272-009-1613-3

Cited by 44 publications

(41 citation statements)

References 29 publications

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“…Further, CoQ10 was shown to reduce UVA-induced MMPs in cultured human dermal fibroblasts [33]. It was reported that it is considered that CoQ10 appears to have also a cutaneous healing effects in vivo [34]. …”

Section: Coenzyme Q10mentioning

confidence: 99%

The Role of Antioxidants in Skin Cancer Prevention and Treatment

Godić

Poljšak²,

Adamič³

et al. 2014

Oxidative Medicine and Cellular Longevity

241

162

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Skin cells are constantly exposed to reactive oxygen species (ROS) and oxidative stress from exogenous and endogenous sources. UV radiation is the most important environmental factor in the development of skin cancer and skin aging. The primary products caused by UV exposure are generally direct DNA oxidation or generation of free radicals which form and decompose extremely quickly but can produce effects that can last for hours, days, or even years. UV-induced generation of ROS in the skin develops oxidative stress when their formation exceeds the antioxidant defense ability. The reduction of oxidative stress can be achieved on two levels: by lowering exposure to UVR and/or by increasing levels of antioxidant defense in order to scavenge ROS. The only endogenous protection of our skin is melanin and enzymatic antioxidants. Melanin, the pigment deposited by melanocytes, is the first line of defense against DNA damage at the surface of the skin, but it cannot totally prevent skin damage. A second category of defense is repair processes, which remove the damaged biomolecules before they can accumulate and before their presence results in altered cell metabolism. Additional UV protection includes avoidance of sun exposure, usage of sunscreens, protective clothes, and antioxidant supplements.

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Section: Coenzyme Q10mentioning

confidence: 99%

The Role of Antioxidants in Skin Cancer Prevention and Treatment

Godić

Poljšak²,

Adamič³

et al. 2014

Oxidative Medicine and Cellular Longevity

241

162

View full text Add to dashboard Cite

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“…It was reported that CoQ10 strongly inhibits oxidative stress in the skin induced by UVB via increasing SOD2 and GPx [109]. It was reported that it is considered that CoQ10 appears to have also a cutaneous healing effect in vivo [110]. …”

Section: Compounds Derived From the Diet With Photoaging/damage Prmentioning

confidence: 99%

Skin Photoaging and the Role of Antioxidants in Its Prevention

et al. 2013

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Photoaging of the skin depends primarily on the degree of ultraviolet radiation (UVR) and on an amount of melanin in the skin (skin phototype). In addition to direct or indirect DNA damage, UVR activates cell surface receptors of keratinocytes and fibroblasts in the skin, which leads to a breakdown of collagen in the extracellular matrix and a shutdown of new collagen synthesis. It is hypothesized that dermal collagen breakdown is followed by imperfect repair that yields a deficit in the structural integrity of the skin, formation of a solar scar, and ultimately clinically visible skin atrophy and wrinkles. Many studies confirmed that acute exposure of human skin to UVR leads to oxidation of cellular biomolecules that could be prevented by prior antioxidant treatment and to depletion of endogenous antioxidants. Skin has a network of all major endogenous enzymatic and nonenzymatic protective antioxidants, but their role in protecting cells against oxidative damage generated by UV radiation has not been elucidated. It seems that skin's antioxidative defence is also influenced by vitamins and nutritive factors and that combination of different antioxidants simultaneously provides synergistic effect.

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“…2 Previous studies have demonstrated that topical CoQ10 application is effective in oxidative stress, 3 photo protection 4 and wound healing. 5 However, large molecular weight (863 g/mol) and poor aqueous solubility (0.7 ng/mL) of CoQ10 limits its penetration through the skin. 6 D-Panthenyl triacetate (PTA) is an oil-soluble derivative of D-panthenol (Figure 1), a precursor of pantothenic acid.…”

Section: Introductionmentioning

confidence: 99%

Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes

Çelik¹,

Sagiroglu²,

Özdemir³

2017

IJN

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Coenzyme Q10 (CoQ10) is a lipid-soluble molecule found naturally in many eukaryotic cells and is essential for electron transport chain and energy generation in mitochondria. D-Panthenyl triacetate (PTA) is an oil-soluble derivative of D-panthenol, which is essential for coenzyme A synthesis in the epithelium. Liposomal formulations that encapsulate both ingredients were prepared and optimized by applying response surface methodology for increased stability and skin penetration. The optimum formulation comprised 4.17 mg CoQ10, 4.22 mg PTA and 13.95 mg cholesterol per 100 mg of soy phosphatidylcholine. The encapsulation efficiency of the optimized formulation for CoQ10 and PTA was found to be 90.89%±3.61% and 87.84%±4.61%, respectively. Narrow size distribution was achieved with an average size of 161.6±3.6 nm, while a spherical and uniform shape was confirmed via scanning electron microscopy and transmission electron microscopy images. Cumulative release of 90.93% for PTA and 24.41% for CoQ10 was achieved after 24 hours of in vitro release study in sink conditions. Physical stability tests indicated that the optimized liposomes were suitable for storage at 4°C for at least 60 days. The results suggest that the optimized liposomal formulation would be a promising delivery system for both ingredients in various topical applications.

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Effect of coenzyme Q10 on cutaneous healing in skin-incised mice

Cited by 44 publications

References 29 publications

The Role of Antioxidants in Skin Cancer Prevention and Treatment

The Role of Antioxidants in Skin Cancer Prevention and Treatment

Skin Photoaging and the Role of Antioxidants in Its Prevention

Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes

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